Effects of different types of written vaccination information on COVID-19 vaccine hesitancy in the UK (OCEANS-III): a single-blind, parallel-group, randomised controlled trial영국(OCEANS-III)의 COVID-19 백신 주저에 대한 다양한 유형의 서면 예방 접종 정보의 영향: 단일 맹검, 병렬 그룹, 무작위 대조 시험Articles Published on 2021-05-132022-08-13 Journal: The Lancet. Public Health [Category] 임상, [키워드] 95% CI addition addressed adjusted Adults Alter analysed assigned benefit Combination condition confidence control condition Controlled trial COVID-19 COVID-19 vaccination COVID-19 vaccination programme COVID-19 vaccine COVID-19 vaccines Decision making Effect effective Effectiveness Efficacy and safety engage Ethnicity finding funding Gender greater group Health health campaigns Hesitancy highlight information ISRCTN less mean difference moderate multiple comparisons National Health Service NIHR NIHR Oxford Health Biomedical Research Centre outcome outcome measure outcomes Oxford Oxford Biomedical Research Centre Oxford COVID-19 Vaccine Hesitancy Scale Oxford Vaccine Confidence and Complacency Scale p values pandemic parallel-group participant Perception Primary outcome public health communications randomised controlled trial Randomly recruit recruited recruitment reduce reduced Registered risk scale seriousness single-blind speed stratified terrain vaccination Vaccine Vaccine hesitancy vaccine hesitancy scale vaccine-hesitant virus was reduced [DOI] 10.1016/S2468-2667(21)00096-7 PMC 바로가기 [Article Type] Articles
Statistical analysis plan for the Surgery for Cancer with Option of Palliative Care Expert (SCOPE) trial: a randomized controlled trial of a specialist palliative care intervention for patients undergoing surgery for cancerRandomized Controlled Trial Published on 2021-04-292022-10-04 Journal: Trials [Category] MERS, SARS, 임상, [키워드] 1:1 all-cause mortality analysis plan assessment Cancer cancer patient control arm days alive expert FACT-G include index Intervention intervention arm malignancies manuscript option outcome palliative Palliative care Patient Primary outcome Randomized Randomized controlled trial Result secondary selected single-blind single-center Statistical analysis plan Study protocol surgery Surgical oncology Time frame usual care [DOI] 10.1186/s13063-021-05256-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Validation of the Withings ScanWatch as a Wrist-Worn Reflective Pulse Oximeter: Prospective Interventional Clinical StudyWithings ScanWatch를 손목에 착용하는 반사형 맥박 산소 농도계로 검증: 전향적 중재 임상 연구Clinical Trial Published on 2021-04-262022-09-12 Journal: Journal of Medical Internet Research [Category] MERS, 임상, 진단, [키워드] 95% CI Accuracy adverse event adverse events Analysis arterial oxygen saturation association biases Bland blood sample Blood samples chronic obstructive chronic obstructive pulmonary disease clinical clinical study collected condition connected watch COPD correlation COVID-19 decrease Effect hands healthy Hypoxemia hypoxia hypoxic conditions Inconclusive Indicator mass meet Mild moderate MONITOR Neural network objective obstructive pulmonary disease occur oximeter oxygen oxygen saturation participant Pearson correlation coefficient Prospective pulmonary disease pulse Pulse oximeter pulse oximetry pulse oxygen saturation Radiometer reflective pulse oximeter Registration removal reported respiratory Respiratory disease respiratory diseases Result Safety single-blind sleep apnea sleep apnea syndrome SpO2 Stage validation wearable Withings ScanWatch [DOI] 10.2196/27503 PMC 바로가기 [Article Type] Clinical Trial
Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients중증 코로나19 환자 치료에 이버멕틴 추가의 유효성 및 안전성 평가Clinical Trial Published on 2021-04-042022-07-29 Journal: BMC Infectious Diseases [Category] 임상, 치료제, [키워드] added affecting Alter average Azithromycin azithromycin- blood lymphocyte count C-reactive protein can be used cause changes in Clinical improvement clinical recovery clinical response control group control groups COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 pneumonia COVID19 pneumonia CRP D-dimer level D-dimer levels decrease drug Effect effective Effectiveness enteral use evaluate evaluated Favipiravir ferritin FiO2 follow-up period gene mutation gene mutations genetic test genetic tests groups Hydroxychloroquine increase in investigated Ivermectin ivermectin metabolism ivermectin treatment laboratory parameter Laboratory parameters lymphocyte material metabolism Mortality mortality rate mortality rates Mutation oxygen oxygen saturation PaO2 partial pressure Partial pressure of oxygen Patient patients performing sequence analysis peripheral capillary phase 3 study Pneumonia prognostic protocol protocols randomization Randomized reduction in reference treatment Result Sanger method SARS CoV-2 SARS-CoV2 Sequence analysis serum serum C-reactive protein severe COVID-19 severe COVID-19 patient Severe COVID-19 pneumonia single-blind solution SpO2 study group supplementary material the study group toxic effect toxic effects Treatment two groups were excluded were given while PMC 바로가기 [Article Type] Clinical Trial
Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial단순 COVID-19 외래 환자 치료를 위한 Peginterferon Lambda-1a: 무작위 위약 대조 시험Randomized Controlled Trial Published on 2021-03-302022-08-13 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 95% CI 95% confidence interval conducted coronavirus disease Coronavirus disease 2019 COVID-19 determine Diagnosis Effect Elevation group hazard ratio IMPROVE interferons Lambda liver transaminase median time Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 NCT04331899 not differ Outpatient outpatients outpatients with uncomplicated Patient Peginterferon Lambda-1a Placebo placebo-controlled trial primary endpoint Randomized Randomized controlled trials randomized placebo-controlled trial receiving resolved SARS-CoV-2 viral shedding secondary endpoint significantly single dose single-blind subcutaneous dose Symptom symptom duration Symptoms the median Therapeutics Treatment Trial type III interferon Type III interferons Viral viral infection viral shedding [DOI] 10.1038/s41467-021-22177-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Brief videoconferencing psychological intervention for reducing COVID-19 related distress: study protocol for a randomized controlled trialCOVID-19 관련 고통을 줄이기 위한 간단한 화상회의 심리적 개입: 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2021-03-092022-09-10 Journal: BMC Public Health [Category] SARS, 임상, [키워드] anhedonia Anxiety carried Controlled trial COVID-19 COVID-19 pandemic Depression distress Effectiveness elevated GHQ-12 Health Organization imperative include Informed consent intensity outcome platform positive post treatment Primary outcome problem problems Psychological Psychological distress Psychological intervention Psychosocial intervention randomised Randomized controlled trial reduce reduced reducing reduction in Registered secondary Secondary outcomes single-blind Social support Stress Study protocol Support Treatment treatment as usual Trial Trial registration usual care videoconferencing WHO with COVID-19 World Health Organization Worry [DOI] 10.1186/s12889-021-10529-x PMC 바로가기 [Article Type] Study Protocol
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials단회 투여 및 ChAdOx1 nCoV-19(AZD1222) 백신의 면역원성 및 효능에 대한 추가 투여 시간의 영향: 4건의 무작위 시험에 대한 통합 분석Meta-Analysis Published on 2021-03-062022-09-10 Journal: Lancet (London, England) [Category] MERS, SARS, 임상, [키워드] 1:1 95% CI addition administration Ageusia All participants Analysis Anosmia antibody antibody levels Antibody Response Antibody responses approved assigned AstraZeneca AZD1222 baseline binding antibody booster dose booster doses Brazil category ChAdOx1 ChAdOx1 nCoV-19 Clinical research Coalition control group control vaccine cough COV005 COVID-19 COVID-19 disease COVID-19-related death Cutoff death defined described dose doses double-blind Efficacy Emergency use Endpoint Evidence evidence of exclusion exploratory Exploratory analyses Exploratory analysis Fever finding first dose FIVE Follow-up for inclusion foundation funding geometric mean geometric mean ratio GMR had no Hospital admission immunoassay immunogenicity immunogenicity data independent indicated individual Infection initial Innovation interim analysis ISRCTN89951424 less lower dose Medicine Medicines Medicines and Healthcare products Regulatory Agency Melinda Gate Melinda Gates N protein NAAT NAAT-positive swab network neutralisation NIHR no evidence of nucleic acid nucleic acid amplification nucleic acid amplification test observation offered Older outcomes Oxford pandemic participant phase 2/3 phase 3 study positive swab primary analysis primary endpoint Primary outcome prime-boost interval priming PROTECT pseudovirus randomised controlled Randomised trial Randomly receive receiving recruited regimen Registered regulatory authority response Safety saline placebo SARS-COV-2 infection SARS-CoV-2 N protein second dose secondary Serious Adverse Events seronegative Seven Shortness of breath single-blind Single-dose South South Africa Standard dose subset supported Swab swabs Symptom symptomatic COVID-19 disease symptomatic infection Telle the primary endpoint the timing the vaccine Trial vaccination Vaccine vaccine efficacy Valley Viral Viral particles [DOI] 10.1016/S0140-6736(21)00432-3 PMC 바로가기 [Article Type] Meta-Analysis
Sniffer dogs as a screening/diagnostic tool for COVID-19: a proof of concept studyCOVID-19에 대한 선별/진단 도구로서의 탐지견: 개념 연구의 증거Research Article Published on 2021-03-052022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] addition applicability Bladder cancer Border can be used classical classical conditioning Colorectal cancer complications conditioning process conducted COVID-19 COVID-19 case COVID-19 cases COVID-19 patient Critical detect Diabetic diabetic patients diagnose Diagnosis dog Face mask Face masks female German shepherd Golden retriever Health helping hypoglycemia identify Infection introduced Lexi male Marco Mask Masks medical condition Melanoma Negative predictive value negative sample participant Particle pharyngeal Pharyngeal secretions positive positive sample predictive values reported Result RT-PCR RT-PCR test Sami SARS-COV-2 infection Screen secretion sensitivity single-blind Sniffer dogs specificity specimen spread of COVID-19 true negative were used [DOI] 10.1186/s12879-021-05939-6 PMC 바로가기 [Article Type] Research Article
Effects of neuromuscular electrical stimulation therapy on physical function in patients with COVID-19 associated pneumonia: Study protocol of a randomized controlled trialResearch article Published on 2021-03-012022-10-05 Journal: Contemporary Clinical Trials Communications [Category] 임상, [키워드] adverse effects approach battery Care clinical rehabilitation control group COVID-19 COVID-19 patient COVID-19 patients early rehabilitation Effect Effectiveness electrical evaluate expected fatigue ICU impairment include intensive care Intervention manuscript mechanical ventilation muscle Muscle strength Muscle thickness Neuromuscular neuromuscular electrical stimulation Non-invasive non-invasive ventilation outcome parallel-group Patient patients with COVID-19 performance physical post-intensive care syndrome presenting Primary outcome protocol quadricep Quadriceps muscle Randomized Randomized controlled trial rehabilitation Respiratory failure secondary secondary outcome Short physical performance battery single-blind Study design Support syndrome therapy Trial [DOI] 10.1016/j.conctc.2021.100742 [Article Type] Research article
Immediate Effects of a Telerehabilitation Program Based on Aerobic Exercise in Women with FibromyalgiaArticle Published on 2021-02-202022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] aerobic analogue analyzed Arm baseline Borg changes in chronic pain Control COVID-19 pandemic distress Effect exercise fibromyalgia Immediate immediate effect Impact improvement intensity Intervention lockdown Pain pain intensity physical physiological Program Psychological distress Randomized Randomized controlled trial rehabilitation scale sensitivity single-blind Spain statistically significant syndrome telerehabilitation Test Visual were measured women [DOI] 10.3390/ijerph18042075 PMC 바로가기 [Article Type] Article