Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care unitsClinical Trial Published on 2021-11-082022-10-04 Journal: Critical Care [Category] MERS, 임상, [키워드] acute respiratory distress alteration ARDS AUC baseline Brazil carried cause Concentration Control correlated COVID-19 COVID-19 patient COVID-19 patients determine dynamic endothelial endothelial damage Endothelial dysfunction Enrollment evaluated Evidence fraction group hemoglobin Hypoxemia ICU Implications in vivo intensive care unit Invasive mechanical ventilation Ischemia Local metabolic rate Microcirculation nasal near-infrared spectroscopy NIRS not differ observation organs oxygen oxygen saturation parameter peripheral positive correlation prognostic prospective observational study reactivity receiving Registered Respiratory Support Result severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity significant difference significantly Skeletal muscle Spain subject supplementary material Support syndrome Therapies Trial two groups vascular occlusion Vasopressor was performed [DOI] 10.1186/s13054-021-03803-2 PMC 바로가기 [Article Type] Clinical Trial
Clinical features of Danon disease and insights gained from LAMP-2 deficiency modelsReview article Published on 2021-11-012022-10-05 Journal: Trends in cardiovascular medicine [Category] 비임상, [키워드] absence animal model autophagic cardiac cells characterized clinical clinical feature clinical trial contribute deficiency demonstrated disease disorder drug dysfunction Effect effective Evidence feature Gene therapy humans hypertrophic cardiomyopathy impairment in vitro in vivo isoform LAMP2 mechanism Mental mimicking molecular Mutation pathology Patient phenotype pluripotent stem cell potential therapy powerful tool Protein provided Research resulting Skeletal muscle Symptom therapeutic Treatment weakness while X-linked [DOI] 10.1016/j.tcm.2021.10.012 [Article Type] Review article
Molecular Mechanisms of Muscle FatigueReview Published on 2021-10-272023-06-12 Journal: International Journal of Molecular Sciences [Category] MERS, [키워드] atrophy fatigue Muscle function Skeletal muscle [DOI] 10.3390/ijms222111587 PMC 바로가기 [Article Type] Review
Acute Myocardial Injury and Rhabdomyolysis in COVID-19 Patients: Incidence and MortalityCardiology Published on 2021-10-192022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ACE2 Angiotensin converting enzyme 2 (ACE2) angiotensin-converting enzyme 2 benefit binding Cardiomyopathy cardiovascular disease caused cohort study coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient COVID-19 patients creatine kinase (ck) Critical CVD defined elevated enzyme female fiber fibrosis Frequency greater higher risk Hospitalized hospitalized COVID-19 patient hospitalized patients Host hyperinflammatory cytokine storm hypoxic immune in-hospital mortality incidence indirect mechanism Injury ischemic injury male material Mortality mortality rate muscle myocardial injury myocardial ischemia type 2(mi type 2) myocarditis Necrosis Odds ratio outcome pathophysiology Patient patients with COVID-19 Primary outcome Result retrospective rhabdomyolysis SARS-CoV-2 virus serum Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) significantly higher Skeletal muscle Stress systemic cytokine Troponin-T [DOI] 10.7759/cureus.18899 PMC 바로가기 [Article Type] Cardiology
Angiotensin‐Converting Enzyme 2 (SARS‐CoV‐2 receptor) expression in human skeletal muscle인간 골격근에서의 안지오텐신 분비 효소 2 (SARS -COV -2 수용체) 발현Original Article Published on 2021-10-042022-09-01 Journal: Scandinavian Journal of Medicine & Science in Spor [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 expression ACE2 protein Adiposity age analyzed angiotensin association biopsies biopsy body composition body fat cardiorespiratory cardiorespiratory fitness collected COVID‐19 determine determined by DXA enzyme exercise explained Express expression fat Interaction lean mass leg legs low fat men men and women Multiple Multiple regression analysis obesity positive Predictive Predictive value Previous studies previous study protein expression receptor regression analysis SARS‐CoV‐2 Sex difference sex differences sexual dimorphism Skeletal muscle slope subject Variability variance vastus lateralis vastus lateralis muscle VO2max was determined was reduced weight western blot women [DOI] 10.1111/sms.14061 PMC 바로가기 [Article Type] Original Article
Functional Outcomes and Their Association With Physical Performance in Mechanically Ventilated Coronavirus Disease 2019 Survivors at 3 Months Following Hospital Discharge: A Cohort StudyObservational Study Published on 2021-10-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] 6-minute walking distance addition adipose chest CT scan collected coronavirus disease diffusing European functional had more handgrip strength Health Assessment hospital hospital discharge ICU lung measure measurement mechanically ventilated Medical Research Council Month outcome pandemic Patient patients performance performed physical Physical disability predicted prospective observational cohort Pulmonary function Pulmonary function test severe coronavirus disease Skeletal muscle skeletal muscle injury survivor Survivors sustained tissue tissue area university walking distance was used weakness [DOI] 10.1097/CCM.0000000000005089 PMC 바로가기 [Article Type] Observational Study
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunityResearch Article Published on 2021-10-012022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS, [키워드] ACE2, angiotensin-converting enzyme II adverse effect antibody approach BCA, bicinchoninic acid BLI, bioluminescent imaging can be used Cationic lipid CDM, chemically defined media Cell cellular characterized COVID19 CTCS, clarified tissue culture supernatant CVS, concentrated vesicle suspension DOPE, dioleoyl phosphatidylethanolamine dose DOTAP, dioleoyl-3-trimethylammonium propane DTZ, diphenylterazine elicited encapsulation ER, endoplasmic reticulum EV, extracellular vesicle Evidence Exosome Exosomes Extracellular vesicles form functional had no human cell Humoral response HUVEC, human umbilical vein endothelial cell immunogenic induce injection Lipid nanoparticle lipofection LNP LNP, Lipid Nanoparticle long-lasting luciferase expression mice mRNA NTA, nanoparticle tracking analysis nucleocapsid ORF, open reading frame pfPBS, particle-free PBS previous study Protein repeated responses Safe SARS-CoV-2 immunity SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography Skeletal muscle spike sustained T-cell tested the SARS-CoV-2 tissue Toxicity vitreous fluid [DOI] 10.1016/j.jbc.2021.101266 PMC 바로가기 [Article Type] Research Article
Muscle strength and muscle mass as predictors of hospital length of stay in patients with moderate to severe COVID‐19: a prospective observational studyObservational Study Published on 2021-09-142022-10-04 Journal: Journal of Cachexia, Sarcopenia and Muscle [Category] SARS, 임상, [키워드] age analyses association body mass index both sexes Clinical outcome condition covariates COVID‐19 COVID‐19 patients COVID‐19 critically ill patients died disease evaluated evidence of greater handgrip handgrip strength hazard ratio Health hospital Hospital admission Hospital stay Hospitalization hospitalized patient hypertension Intensive invasive mechanical investigated lateralis LOS lowest magnitude male muscle muscle mass Muscle strength obesity Patient patients with moderate positive Predictive predictor Prevalence prevalent Prognosis prospective observational study remained required Result SARS‐CoV‐2 Skeletal muscle smoking Standard deviation statistically significant strength the patient type 2 diabete vastus were excluded [DOI] 10.1002/jcsm.12789 PMC 바로가기 [Article Type] Observational Study
Potential Physiological and Cellular Mechanisms of Exercise That Decrease the Risk of Severe Complications and Mortality Following SARS-CoV-2 InfectionReview Published on 2021-08-312022-10-29 Journal: Sports [Category] COVID-19, [키워드] acute respiratory syndrome addition affected age Antiviral cardiorespiratory cardiovascular disease caused cellular Complication contribute coronavirus coronavirus disease Course COVID-19 Defense Deterioration determine diabetes disease severity exercise Health highlight Host hypertension immune immune system immunological function immunology IMPROVE inflammatory disorders low-grade systemic inflammation Mitochondrial function molecular mechanism Mortality obesity outcome pandemic physical activity physiological Potential PROTECT Regular renal risk factor SARS-CoV-2 Skeletal muscle sustained the antibody response Threats vaccination virus [DOI] 10.3390/sports9090121 PMC 바로가기 [Article Type] Review
Liberal Intravenous Fluid Administration in a Rare Case of Severe Rhabdomyolysis Secondary to SARS-CoV-2Internal Medicine Published on 2021-08-162022-10-31 Journal: Cureus [Category] COVID-19, [키워드] administration Admission Affect African American asymptomatic infection COVID-19 creatinine kinase death discharged home Electrolytes gastrointestinal tract hepatocellular injury Hospitalization include infected patients information intravenous fluids liberal male management neurological occur Patient rare disease renal renal function reported rhabdomyolysis sars-2-coronavirus SARS-CoV-2 SARS-COV-2 infection secondary to Seven severity significant level Skeletal muscle the United State tissue treat treated virus Wuhan, China [DOI] 10.7759/cureus.17234 PMC 바로가기 [Article Type] Internal Medicine