Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기
New insights into antibody levels against SARS-CoV-2 for healthcare personnel vaccinated with tozinameran (Comirnaty)Article Published on 2022-11-032022-11-15 Journal: PLoS ONE [Category] SARS, 진단, [키워드] activated addition addressed administration Alto Andújar antibody booster dose COVID-19 determine Dilution Elecsy Evolution exhibited Germany Guadalquivir healthcare personnel Healthcare professional humoral IgG in vitro infected patients material Neutralizing antibodies New non-infected pandemic platform Roche SARS-CoV-2 SARS-CoV-2 vaccine second dose serum sample Spike protein subject Thermo Fisher Scientific titer total antibody vaccination Vaccine Volunteer volunteers [DOI] 10.1371/journal.pone.0276968 PMC 바로가기
Humoral response and safety of BNT162b2 mRNA vaccine in children with rheumatic diseasesArticle Published on 2022-11-022022-11-15 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, [키워드] acute respiratory syndrome Administered Anti-RBD IgG antibody Antibody Response approval baseline biologic BNT162b2 mRNA BNT162b2 mRNA vaccine children Cohort cohort of patient Combined therapy coronavirus coronavirus disease COVID-19 disease Disease activity domain dose dose regimen effective elevated evaluated humoral Humoral response IgG antibody immunogenicity immunomodulatory IQR Local median mRNA vaccine of BNT162b2 paediatric rheumatic disease. pandemic Patient RBD receiving rheumatic disease safety profile SARS-CoV-2 second dose significantly lower Spike protein study period systemic side effect titre treated Treatment Vaccine were measured [DOI] 10.1093/rheumatology/keac140 PMC 바로가기
Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in miceArticle Published on 2022-11-022022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] Activation Arm cellular COVID-19 disease demonstrated development disease Efficacy hamster humoral IgA immune Immunity immunization induce intramuscular intramuscularly intranasal intranasally Lower respiratory tract lung Lung pathology medical need memory B cell mice mucosal mucosal immune pandemic promote protective immunity public health rapid progress response resulting robust S-2P Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Seroconversion Spike protein systemic immune response the SARS-CoV-2 Transmission unique upper respiratory tract Vaccine vaccine candidate variants viral clearance weight loss while [DOI] 10.1371/journal.pone.0272594 PMC 바로가기
Reduced humoral but stable cellular SARS-CoV-2-specific immunity in liver transplant recipients in the first year after COVID-19Article Published on 2022-11-022022-11-15 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, [키워드] anti-Nucleocapsid IgG anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody Antigen booster vaccination cellular cellular immunity Cohort Concentration convalescent COVID-19 detectable domain Endemic humoral IFN-γ IgG immune response Immunity Immunoglobulin Immunosuppressed Immunosuppression immunosuppressive individual liver Liver transplantation membrane nucleocapsid Prevalence protective immunity reactivity Receptor binding domain recipient remained retrieved robust SARS-CoV-2 significantly increased Spike protein stimulated T cell T cell response therapy vaccination [DOI] 10.1371/journal.pone.0276929 PMC 바로가기
Critical pediatric neurological illness associated with COVID-19 (Omicron BA.2.3.7 variant) infection in Taiwan: immunological assessment and viral genome analysis in tertiary medical centerArticle Published on 2022-11-012022-11-16 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, [키워드] Amino acid amino acid variation cause cerebrospinal fluid children collected Complication COVID-19 COVID-19 infection diagnosed Encephalitis Epidemic explain immunological incidence increase in Infection Inflammatory marker Lineage medical record Mutation N-terminal domain nasal swab neurological Neurological complication Neurological symptom Neurological symptoms omicron Patient pediatric pediatric cases Pediatric patient Pediatric patients positive Protein reported SARS-CoV-2 sequence Sequencing Severe neurological symptoms spike Spike protein Strains Taiwan tested the S protein variant Variation viral genome analysis whole genome Whole genome sequencing whole genome sequencing. with COVID-19 [DOI] 10.1016/j.ijid.2022.09.001 PMC 바로가기
An experimental test of the nicotinic hypothesis of COVID-19Article Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acetylcholine receptors acute respiratory syndrome binding binding competition assays cells competing complex coronavirus COVID-19 disease ectodomain effort expressed Hypothesis Infection Ligand nicotinic receptors pathophysiological mechanism peptides performed Rabies virus receptor receptors S1 domain SARS-CoV-2 SARS-CoV-2 spike protein Spike protein spike protein. suggested Symptom tested the SARS-CoV-2 unlikely virus [DOI] 10.1073/pnas.2204242119 PMC 바로가기
Is there an interplay between the SARS-CoV-2 spike protein and Platelet-Activating factor?Article Published on 2022-11-012023-07-10 Journal: BioFactors (Oxford, England) [Category] COVID19(2023년), [키워드] ADP collagen coronavirus human platelet-rich plasma Monocytes platelet-activating factor Platelets Spike protein thrombin Vaccines. [DOI] 10.1002/biof.1877 PMC 바로가기
Differential avidity determination of IgG directed towards the receptor-binding domain (RBD) of SARS-CoV-2 wild-type and its variants in one assay: Rational tool for the assessment of protective immunityArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome avidity binding coronavirus IgG IgG RBD Infection LINE mandatory marker mRNA much lower Omicron variant Protective protective immunity RBD reached Receptor-binding domain recom Line SARS-CoV-2 IgG. SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection serology Spike protein the receptor-binding domain vaccination variant wild-type WT SARS-CoV-2 [DOI] 10.1002/jmv.28006 PMC 바로가기
Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2PArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Beta challenge coronavirus COVID-19 COVID-19 vaccine Delta dose Effectiveness hamster hamster challenge study highest live SARS-CoV-2 Live virus lung MVC-COV1901 neutralization Neutralizing antibody titer Omicron variant pathology prefusion PROTECT pseudovirus recombinant regimen S-2P SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 vaccine spike Spike protein subunit Subunit vaccine suggested vaccination Vaccines variant Variant of concern. variants variants of concern virus Wuhan [DOI] 10.1093/infdis/jiac153 PMC 바로가기