Could Statin Therapy Be Useful in Patients With Coronavirus Disease 2019 (COVID-19)?Cardiovascular Medicine Published on 2021-10-272022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] abnormality acute respiratory disease syndrome Affect ARDS Arrhythmias Cardiomyopathy cardiovascular disorder Coagulation complications of COVID-19 coronavirus disease coronavirus disease (COVID-19) COVID-19 COVID-19 patient Critical death develop distress endothelial function enzyme Evidence exaggerated inflammatory response heart failure Inflammation modulate myocardial injury myocarditis oxidative stress Perspective pleiotropic receptor respiratory infection resulting severity statin statins syndrome thrombosis [DOI] 10.3389/fcvm.2021.775749 PMC 바로가기 [Article Type] Cardiovascular Medicine
COVID-19 and lipids. The role of lipid disorders and statin use in the prognosis of patients with SARS-CoV-2 infectionReview Published on 2021-10-252022-10-29 Journal: Lipids in Health and Disease [Category] COVID-19, MERS, [키워드] Anti-inflammatory Antiviral Arterial hypertension available data cardiovascular disease cardiovascular diseases caused Comorbidities coronavirus coronavirus disease Course COVID-19 COVID-19 infection diabetes disorder dyslipidemia Effect greater immunomodulatory IMPROVE lipids Mortality Numerous obesity observational study outcomes pandemic Patient Prognosis prognosis of patient reduced risk risk factor SARS-CoV-2 SARS-COV-2 infection shown statins the SARS-CoV-2 therapy Treatment [DOI] 10.1186/s12944-021-01563-0 PMC 바로가기 [Article Type] Review
Anti-flavivirus Properties of Lipid-Lowering DrugsPhysiology Published on 2021-10-072022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] analyzed Antiviral antiviral target Antiviral treatment antivirals cholesterol drug Effect effective fatty acids FDA-approved drug Flaviviridae flavivirus Host Infection infections Lipid lipid metabolism lipids metabolic pathway metformin Pathogens property Regulation replicative required Safe shown signaling pathway statins triggered Vaccine virus ZIKV [DOI] 10.3389/fphys.2021.749770 PMC 바로가기 [Article Type] Physiology
Plausible Positive Effects of Statins in COVID-19 PatientCOVID-19 환자에서 스타틴의 그럴듯한 긍정적 효과Review Published on 2021-10-012022-09-11 Journal: Cardiovascular toxicology [Category] SARS, 치료제, [키워드] Anti-inflammatory Antiviral effect biological processe cholesterol chronic drug Course COVID-19 COVID-19 infection COVID-19 pandemic disadvantage Disadvantages disease drug Effect epidemiological Evidence extreme heart disease include Inflammation involved molecular pharmacological pleiotropic effect Pleiotropic effects SARS-CoV-2 SARS-CoV-2-positive patients severity statin statins therapy Topic Treatment [DOI] 10.1007/s12012-021-09674-x PMC 바로가기 [Article Type] Review
Improved COVID-19 Outcomes following Statin Therapy: An Updated Systematic Review and Meta-analysis스타틴 요법 후 Covid-19 결과 개선 : 업데이트 된 체계적인 검토 및 메타 분석Review Published on 2021-09-232022-09-10 Journal: BioMed Research International [Category] 임상, [키워드] 95% CI Admission all-cause mortality Analysis carried Clinical studies clinical study Combined Effects COVID-19 COVID-19 case COVID-19 cases COVID-19 mortality COVID-19 patients death disease transmission Effect effective finding Hospital admission Hospitalization ICU ICU admission IMPROVE Improved in some In-hospital indicated intensive care intensive care unit intubation investigated leads Meta-analysis no significant effect outcome outcome measures outcomes performed random effect Randomized reduce reduced reduction reduction in review severity significantly statin statins statistical analysis Statistical power subjects the patient therapy tracheal tracheal intubation Treatment Vaccine [DOI] 10.1155/2021/1901772 PMC 바로가기 [Article Type] Review
Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial)혈관재생 가능성이 없는 위독한 사지 허혈이 있는 당뇨병 환자에서 동종 지방 조직 유래 및 확장 중간엽 기질 세포의 근육내 투여의 효능 및 안전성: 무작위 대조 이중 맹검 2상 임상 시험을 위한 연구 프로토콜(The NOMA Trial)Study Protocol Published on 2021-09-062022-09-10 Journal: Trials [Category] SARS, 비임상, 임상, [키워드] adipose Adipose tissue Adipose-derived mesenchymal stromal cells Administered administration Advanced therapy medicinal products adverse event adverse events Allogeneic Angiogenesis animal model animal models antiplatelet assigned breath Cell Cell therapy chronic clinical development Clinical practice clinical trial control group Critical Critical limb ischemia current data set demonstrated develop diabetes Diabetes Mellitus diabetic patient dose double-blind Efficacy eligible patient evaluate evaluated feasibility Health Organization health problem humans IMPROVE induce intramuscular Ischemia life limb lower limb Mesenchymal stromal cells multicenter outcome parameters Patient Phase II clinical trial placebo-controlled trial Primary outcome protocol public health Quality of life Randomized Randomly Registration Research revascularization secondary Secondary outcomes shown statins step stromal cell stromal cells study period Study protocol Tertiary the disease therapeutic therapeutic option therapeutic options therapy tissue tissue perfusion Treatment treatment group Trial registration type 2 diabete Type 2 diabetes mellitus World Health Organization [DOI] 10.1186/s13063-021-05430-2 PMC 바로가기 [Article Type] Study Protocol
The Binary Model of Chronic Diseases Applied to COVID-19COVID-19에 적용된 만성 질환의 이진 모델Immunology Published on 2021-09-032022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleviate binary candidate Candidates carrier carriers CD8+ CD8+ T cells chronic chronic disease Chronic diseases class classification clinical implication clinical implications Co-infection Contact contact with coronavirus coronavirus disease Coronavirus disease 2019 corticosteroids (CS) CoV COVID-19 disease drug drugs effective Efficacy following Frequency immune reaction induce Infection JAK inhibitor Model pathogen Pathogens predict Rapamycin Regulatory T cell regulatory T cells respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 patient statins T cells treating COVID-19 Treatment treatment of COVID-19 Treg variant virus [DOI] 10.3389/fimmu.2021.716084 PMC 바로가기 [Article Type] Immunology
Hospital mortality in COVID-19 patients in Belgium treated with statins, ACE inhibitors and/or ARBsObservational Study Published on 2021-09-022022-10-05 Journal: Human vaccines & immunotherapeutics [Category] SARS, 임상, [키워드] 28-day mortality 95% CI ACE ACE inhibitor ACE inhibitors ACEIs activity angiotensin receptor blocker Angiotensin receptor blockers ARB ARBs Belgium Case-control characterized clinical trial Combination combination treatment COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients determine drug Endothelial cell Endothelial dysfunction help hospital Hospital mortality hospitalized COVID-19 patients immunometabolism IMPROVE In-hospital maintain Mortality observational study pathogenesis of COVID-19 Propensity score receptor reduced reduction in statins survival treated Treatment unlikely Vaccine [DOI] 10.1080/21645515.2021.1920271 PMC 바로가기 [Article Type] Observational Study
Repurposing Cardio-Metabolic Drugs to Fight Covid19Covid와 싸우기 위해 심장 대사 약물의 용도를 재구성했습니다Editorial Published on 2021-09-012022-08-31 Journal: High blood pressure & cardiovascular prevention : [Category] 신약개발, [키워드] Abstract COVID19 drug drugs repurposing statins [DOI] 10.1007/s40292-021-00475-5 PMC 바로가기 [Article Type] Editorial
The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis시간 순서 Transcriptomic 분석을 기반으로 한 다발성 장기 기능 장애의 분자 메커니즘 및 COVID-19의 표적 개입Immunology Published on 2021-08-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] acetaminophen Activation addition Algorithm Angiogenesis B2M BFS algorithm Bioinformatics analysis biological process biological processe biological processes Brain caused CD40 CD40LG cell-mediated immune cell-mediated immune response changes in Comparative Compound Coronavirus disease 2019 COVID-19 CSF1 Curcumin CXCL10 cytokine Cytokine storm database defined determine Dexamethasone DNA downloaded drug energy metabolism enrichment analysis FCER1G FIVE gene co-expression network Gene Expression gene expression profile Gene expression profiles Gene ontology Genes heterogeneous high mortality hub genes ICAM1 identify immune gene immune response Immunity initial gene IRF7 LAT Lcn2 lead leukocyte lung metabolism molecular mechanism morphology Multiple multiple organ dysfunction multiple organ heterogeneity myeloid leukocyte neuronal Novel coronavirus olfactory organ organs other compound PageRank pandemic pattern PLAU predicted protein metabolism Protein–protein interaction Regulation Research response resveratrol RHOA rRNA second Spread SRC statins Stress stress response targeted intervention the cytokine storm TNFRSF1A TO-GCN Toxicogenomics Trachea tracheal Transmission Treatment unique was performed was used [DOI] 10.3389/fimmu.2021.729776 PMC 바로가기 [Article Type] Immunology