stem cell – Page 4 – Communicable Diseases Research

Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity

장기 allo-HSCT 생존자에서 백신 접종 후 SARS-CoV-2 T-세포 반응의 결핍은 체액성 면역 감소로 해석됩니다

Article

Published on 2022-05-102022-09-11
Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders

혈액 질환 환자의 SARS-CoV-2 백신 반응 및 돌발성 감염률

Multicenter Study

Published on 2022-05-072022-09-11
Journal: Journal of Hematology & Oncology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] 95% confidence interval Allogeneic stem cell transplantation Analysis antibody Antibody Response Antibody titer Antibody titers Antibody Units Asymptomatic Autologous stem cell transplantation benefit binding antibody unit binding antibody units BNT162b2 Breakthrough infection Breakthrough SARS-CoV-2 infection Cell Cell therapy Clinical efficacy cohort study Complete conducted correlates of protection COVID-19 Cutoff detectable disorder disorders doses Follow-up hematological Hematological malignancies highlight immunization Immunocompromised Immunocompromised patients Immunosuppressed immunosuppressed patient immunosuppressed patients incidence incidence rate Infection Level median Moderna Moderna mRNA-1273 mortality rate Most patient Most patients multicenter multivariate logistic regression multivariate logistic regression analysis Patient Pfizer Pfizer-BioNTech Pfizer-BioNTech BNT162b2 Pneumonia Ratio SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variants severe disease severity significantly lower Spanish stem cell Stem cell transplantation therapy vaccination Vaccine was used
[DOI] 10.1186/s13045-022-01275-7 PMC 바로가기 [Article Type] Multicenter Study

B Cell Aplasia Is the Most Powerful Predictive Marker for Poor Humoral Response after BNT162b2 mRNA SARS-CoV-2 Vaccination in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

B 세포 무형성은 동종 조혈모세포 이식 환자에서 BNT162b2 mRNA SARS-CoV-2 백신 접종 후 불량한 체액 반응에 대한 가장 강력한 예측 마커입니다

Article

Published on 2022-05-012022-09-11
Journal: Transplantation and cellular therapy [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술,

[키워드] 95% confidence interval absence administration age allo-HSCT Allogeneic allogeneic hematopoietic stem cell transplantation Analysis analyzed anti-SARS-CoV-2 vaccination Antibody Response Antibody responses aplasia B cell B cells B-cell BNT162b2 BNT162b2 mRNA CD4 CD8 characteristic close monitoring Cohort COVID-19 Donor Efficacy entire cohort evaluate evaluated Factor hematopoietic Hematopoietic stem cell highest HSCT humoral Humoral response immune response Immune status Immunosuppressed immunosuppressed patients injection lymphocyte Lymphocyte count lymphopenia median MOST mRNA natural killer cell Natural killer cells Odds ratio of BNT162b2 Patient Poor predict provided recipient recipients reported responders response response rate SARS-CoV-2 SARS-CoV-2 mRNA SARS-CoV-2 vaccination SARS-CoV-2 vaccine Specific STEM stem cell Stem cell transplantation T cell T cells the antibody response transplantation Treatment Univariate analysis Vaccine were assessed
[DOI] 10.1016/j.jtct.2022.02.018 PMC 바로가기 [Article Type] Article

Adaptation of the PERCEPT myeloma prehabilitation trial to virtual delivery: changes in response to the COVID-19 pandemic

가상 분만에 대한 PERCEPT 골수종 사전 재활 시험의 적응: COVID-19 전염병에 대한 대응의 변화

Review

Published on 2022-04-082022-09-11
Journal: BMJ Open [Category] 임상,

In Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy Receptor

유인 수용체를 사용한 SARS-CoV2 감염에 대한 생체 내 조혈 줄기 세포 유전자 치료

Article

Published on 2022-04-012022-09-11
Journal: Human gene therapy [Category] COVID19(2023년), SARS, 변종,

[키워드] abundance Adenovirus adjust airway Antiviral antiviral efficacy approach approaches Bone marrow CD46 Cell creating cytokine cytokine production decoy decoy receptor diminishe dose effector proteins elements erythrocytes erythroid cells erythropoiesis example expressed expression Gene therapy hematopoietic Hematopoietic stem cell hematopoietic system in vivo in vivo HSC gene therapy. Infection Intervention Intravenous injection less lethal dose Lung pathology mice neutralizing capacity not affect performed Peripheral blood pilot study Prophylaxis reached receptor receptor protein reduced Regulatory resulting rhesus rhesus macaque sACE2 SARS-CoV2 SARS-CoV2 infection SARS-CoV2 vaccine SARS-CoV2 vaccines secreted shown significantly spleen STEM stem cell survived susceptible Symptoms therapy transcriptional transduced Vaccine variant Viremia while β-globin
[DOI] 10.1089/hum.2021.295 PMC 바로가기 [Article Type] Article

Safety of DW-MSC infusion in patients with low clinical risk COVID-19 infection: a randomized, double-blind, placebo-controlled trial

Clinical Trial

Published on 2022-04-012022-10-05
Journal: Stem Cell Research & Therapy [Category] 임상,

[키워드] Adverse adverse events baseline Biomarker Cell cells change Clinical characteristics Clinical course clinical risk clinical trial complications Course COVID-19 COVID-19 infection Cytokines discharged dose dose-dependent double-blind Efficacy enrolled exhibited feasibility follow-up period group groups High-dose hospital immunomodulatory properties improve clinical outcome Inflammatory marker Liver function low-dose Mesenchymal stem cells MSC MSCs observation period Occurrence outcome Patient Placebo placebo-controlled placebo-controlled trial profile progression provided Randomized randomized clinical trial Randomized controlled trial Safety SARS-CoV-2 severity single intravenous infusion stem cell study group study groups study period subject TEAE therapeutic efficacy therapeutic potential therapy Tolerability treated treatment-emergent adverse event vital sign
[DOI] 10.1186/s13287-022-02812-4 PMC 바로가기 [Article Type] Clinical Trial

Mesenchymal stem cell treatment for COVID-19

Review article

Published on 2022-03-102022-10-05
Journal: EBioMedicine [Category] SARS, 바이오마커, 임상, 치료법,

Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes

게놈 전반에 걸친 분석을 통해 SARS-CoV-2 바이러스 유전자 Orf9c가 인간 다능성 줄기 세포 유래 심근세포에 미치는 해로운 영향을 보여줍니다

Article

Published on 2022-03-082022-09-11
Journal: Stem Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법,

[키워드] Abnormalities abnormality acute respiratory syndrome acute respiratory syndrome coronavirus ameliorated analyses Analysis Apoptosis apoptotic approved ATP ATP synthesis cardiac dysfunction cardiac injury cardiomyocyte caused Cell cellular characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death defined detrimental detrimental effect detrimental effects disease down-regulated drug Drug administration dysfunction electrical ENCODE expression Factor Factors food functional Genes Genome heart disease heart muscle human pluripotent stem cell Impact Inflammation Injury Ivermectin manifestation Manifestations meclizine meclizine. molecular mechanism molecular mechanisms Orf9c overexpression Pathways Protein Proteins Proteomic analysis reduced respiratory restored SARS-CoV-2 SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly stem cell Therapeutic approach Transcriptomic analyses transcriptomic analysis U.S. Food and Drug Administration up-regulated
[DOI] 10.1016/j.stemcr.2022.01.014 PMC 바로가기 [Article Type] Article

Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis

폐 섬유증에서 폐포 상피 줄기 세포 노화 및 노화 관련 분화 장애의 분자 기전

Review

Published on 2022-03-032022-09-11
Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] accelerated alveolar caused Cell cell senescence cellular senescence COVID-19 Degradation developmental differentiation disorder disrupt DNA damage DNA damage response dysfunction epithelial fibrosis followed by framework Idiopathic pulmonary fibrosis induce inhibiting inhibitor Intervention IPF low-grade inflammation mechanism molecular mechanism molecular mechanisms OIS oncogene pathway Premature Protein pulmonary pulmonary fibrosis replicative replicative senescence reported reverse transcriptase RNA SARS-CoV-2 viral infection senescence senescent cell senescent cells STEM stem cell suppression susceptibility telomerase telomerase and telomeres. telomeres TERC TERT TGF TGF-β TGF-β signalling TPP1 transcriptase Viral viral infection
[DOI] 10.3390/cells11050877 PMC 바로가기 [Article Type] Review

SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism

SARS-COV-2는 적혈구 전구체를 감염시키고 헤모글로빈과 철 대사를 조절시킨다

Article

Published on 2022-02-182022-09-10
Journal: Stem cell reviews and reports [Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] accompanied ACE2 receptor acute respiratory distress aggravate Alpha analyzed Anemia Bilirubin Blood Blood samples cause CD147 Cell cells Coagulopathies Coagulopathy concentrations contribute Course COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients death Degradation diagnostic differentiation door dysregulation erythroid Erythroid precursors expansion Express ferritin HAMP healthy donor healthy donors heme hemoglobin Hemoglobin biosynthesis Hemoglobin degradation hepcidin homeostasis hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia identify impair in vitro infect inhibit iron Iron metabolism mass spectrometry metabolism Mortality mRNA expression multiorgan failure opens oxygen Peripheral blood precursor progenitor qPCR analysis Raman Trapping Microscopy RBC RBCs Red red blood cell red blood cells reduced respiratory distress Result SARS-CoV-2 SARS-COV-2 infection serum Serum ferritin severe COVID-19 disease severely ill COVID-19 patients severity Spectroscopy stem cell stem cells susceptible Therapeutic strategies total bilirubin Transferrin variant were infected Whole blood Zinc
[DOI] 10.1007/s12015-021-10322-8 PMC 바로가기 [Article Type] Article