Sensitivity of Rapid Antigen Testing and RT-PCR Performed on Nasopharyngeal Swabs versus Saliva Samples in COVID-19 Hospitalized Patients: Results of a Prospective Comparative Trial (RESTART)Article Published on 2021-09-092022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Antigen applied approach assays Basel biosensor collected Comparative conducted COVID-19 COVID-19 diagnosis Diagnosis diagnostic duration of symptom exhibited help Hospitalized hospitalized patient hospitalized patients intensive care investigated IQR mitigate much lower nasopharyngeal Nasopharyngeal swab Non-invasive Patient Prospective prospective observational study Rapid rapid antigen test rapid antigen testing RAT RATs Result RT-PCR RT-PCR testing Saliva salivary Sample SARS-CoV-2 SARS-CoV-2 diagnosis sensitivity shortage of reagent specificity specimen Standard Q step Swab swabs Switzerland Test Testing the median Viral transport medium VTM was used [DOI] 10.3390/microorganisms9091910 PMC 바로가기 [Article Type] Article
Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial)혈관재생 가능성이 없는 위독한 사지 허혈이 있는 당뇨병 환자에서 동종 지방 조직 유래 및 확장 중간엽 기질 세포의 근육내 투여의 효능 및 안전성: 무작위 대조 이중 맹검 2상 임상 시험을 위한 연구 프로토콜(The NOMA Trial)Study Protocol Published on 2021-09-062022-09-10 Journal: Trials [Category] SARS, 비임상, 임상, [키워드] adipose Adipose tissue Adipose-derived mesenchymal stromal cells Administered administration Advanced therapy medicinal products adverse event adverse events Allogeneic Angiogenesis animal model animal models antiplatelet assigned breath Cell Cell therapy chronic clinical development Clinical practice clinical trial control group Critical Critical limb ischemia current data set demonstrated develop diabetes Diabetes Mellitus diabetic patient dose double-blind Efficacy eligible patient evaluate evaluated feasibility Health Organization health problem humans IMPROVE induce intramuscular Ischemia life limb lower limb Mesenchymal stromal cells multicenter outcome parameters Patient Phase II clinical trial placebo-controlled trial Primary outcome protocol public health Quality of life Randomized Randomly Registration Research revascularization secondary Secondary outcomes shown statins step stromal cell stromal cells study period Study protocol Tertiary the disease therapeutic therapeutic option therapeutic options therapy tissue tissue perfusion Treatment treatment group Trial registration type 2 diabete Type 2 diabetes mellitus World Health Organization [DOI] 10.1186/s13063-021-05430-2 PMC 바로가기 [Article Type] Study Protocol
Performance of the Abbott SARS-CoV-2 IgG II Quantitative Antibody Assay Including the New Variants of Concern, VOC 202012/V1 (United Kingdom) and VOC 202012/V2 (South Africa), and First Steps towards Global Harmonization of COVID-19 Antibody Methods우려의 새로운 변종, VOC 202012/V1(영국) 및 VOC 202012/V2(남아프리카)를 포함한 Abbott SARS-CoV-2 IgG II 정량적 항체 분석의 성능, COVID-19 항체의 글로벌 조화를 향한 첫 단계 행동 양식Immunoassays Published on 2021-07-142022-09-10 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] Abbott Abbott SARS-CoV-2 IgG acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analytical performance anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody assay Antigen appear binding clinical decision comprehensive evaluation concern Concordance coronavirus correlation COVID-19 COVID-19 pandemic Decision making evaluated Evaluation generate harmonization IgG immune response Including initial initial stages introduced lack linear natural infection New nucleocapsid protein Nucleocapsid proteins parameter performance performed plethora positive protocols Quantitative reference material Reference materials respiratory response reverse transcription-PCR RT-PCR SARS-CoV-2 sensitivity serology serology test severe acute respiratory syndrome Coronavirus South Africa specificity Spike protein Stage step tested the spike protein Trial United Kingdom variants VoC were assessed [DOI] 10.1128/JCM.00288-21 PMC 바로가기 [Article Type] Immunoassays
Next Steps for Efficacy Evaluation in Clinical Trials of COVID-19 VaccinesCorrespondence Published on 2021-07-012022-10-05 Journal: Engineering [Category] 임상, [키워드] clinical COVID-19 step [DOI] 10.1016/j.eng.2021.04.013 [Article Type] Correspondence
Impact of the COVID-19 pandemic on Caribbean Medical Students: A cross-sectional studyResearch article Published on 2021-07-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 유전자 메커니즘, [키워드] affected Anxiety Caribbean change clinical COVID-19 COVID-19 pandemic cross cross-sectional depression score effective Impact IMPROVE introduced less lockdown medical medical school MOST Physicians professional reported Research School Schools shown step student students [DOI] 10.1016/j.amsu.2021.102515 [Article Type] Research article
Assessment of Successful qRT-PCR of SARS-CoV-2 Assay in Pool Screening Using Isopropyl Alcohol Purification Step in RNA ExtractionResearch Article Published on 2021-06-082022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] alcohol analysed assessment average checked Concentration Council COVID-19 determinant E gene E-gene evaluate extracted RNA extraction group ICMR Isopropyl molecular Nanodrop parameter pool positive protocol purification purified purified RNA qRT-PCR reagents real-time RT-PCR Research RNA RNA purification RNAseP RT-PCR SARS-CoV-2 Screening second set selected sensitivity Sensitivity and specificity significantly increased specificity specimen specimens spectrophotometer step suggested treated Treatment was tested [DOI] 10.1155/2021/6653950 PMC 바로가기 [Article Type] Research Article
Assessment of Successful qRT-PCR of SARS-CoV-2 Assay in Pool Screening Using Isopropyl Alcohol Purification Step in RNA ExtractionResearch Article Published on 2021-06-082022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] alcohol analysed assessment average checked Concentration Council COVID-19 determinant E gene E-gene evaluate extracted RNA extraction group ICMR Isopropyl molecular Nanodrop parameter pool positive protocol purification purified purified RNA qRT-PCR reagents real-time RT-PCR Research RNA RNA purification RNAseP RT-PCR SARS-CoV-2 Screening second set selected sensitivity Sensitivity and specificity significantly increased specificity specimen specimens spectrophotometer step suggested treated Treatment was tested [DOI] 10.1155/2021/6653950 PMC 바로가기 [Article Type] Research Article
Assessment of Successful qRT-PCR of SARS-CoV-2 Assay in Pool Screening Using Isopropyl Alcohol Purification Step in RNA ExtractionRNA 추출에서 이소 프로필 알코올 정제 단계를 이용한 풀 스크리닝에서 SARS-COV-2 분석의 성공적인 QRT-PCR 평가Research Article Published on 2021-06-082022-09-10 Journal: BioMed Research International [Category] 바이오마커, [키워드] alcohol analysed assessment average average value best checked Concentration Council COVID-19 determinant E gene E-gene evaluate extracted RNA extraction followed by group ICMR Isopropyl isopropyl alcohol Medical research molecular Nanodrop parameter pool positive protocol purification purified purified RNA purity qRT-PCR reagents real-time RT-PCR reason reason for Research RNA RNA purification RNAseP RT-PCR SARS-CoV-2 Screening second set selected sensitivity Sensitivity and specificity significantly increased specificity specimen specimens spectrophotometer step suggested treated Treatment was tested [DOI] 10.1155/2021/6653950 PMC 바로가기 [Article Type] Research Article
Patient Monitoring Alarms in an Intensive Care Unit: Observational Study With Do-It-Yourself Instructions중환자실의 환자 모니터링 알람: DIY 지침에 따른 관찰 연구Observational Study Published on 2021-05-282022-09-12 Journal: Journal of Medical Internet Research [Category] 임상, 진단, [키워드] alarm alarm fatigue alarm management alarm system alarm system quality Analysis analyzed average blood pressure clinical alarms collected Complete component condition conditions conducted continuous monitoring COVID-19 Data analysis Data science develop deviate Device Digital health dimensions effective electrocardiogram essential element exacerbated exposure to fatigue framework ggplot2 handling heart rate help ICU identify induce instruction intensive care intensive care unit Intervention invasive log low blood pressure management Medical devices Metrics monitoring MOST normal range objective observational study occurred parameter Patient patient monitoring patient safety patients per day provide quantified R package reduce respiratory rate responsiveness Result room type Satisfaction significantly step suit surgical technological innovation the patient ventilator versed vital parameter [DOI] 10.2196/26494 PMC 바로가기 [Article Type] Observational Study
Physical activity and mental well-being under COVID-19 lockdown: a cross-sectional multination studyResearch Published on 2021-05-272022-10-28 Journal: BMC Public Health [Category] COVID-19, SARS, [키워드] activity Administered Adults Australian coronavirus COVID-19 cross-sectional Decline deleterious effect dimension Effect exercise exhibited France groups highest increases in International investigated lockdown lowest Mental mental health mental well-being pandemic participant per day physical activity recorded reduced reduction reduction in reported Result screen time sedentariness Sedentary behavior step supplementary material USA were recorded women [DOI] 10.1186/s12889-021-10931-5 PMC 바로가기 [Article Type] Research