Association of Prior BNT162b2 COVID-19 Vaccination With Symptomatic SARS-CoV-2 Infection in Children and Adolescents During Omicron PredominanceArticle Published on 2022-06-142022-11-16 Journal: JAMA [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI access adjusted adjusted odds ratio Adolescent Adults age amplification Analysis association BNT162b2 booster booster dose Case-control children conducted Control COVID-19 COVID-19 vaccine dose Effectiveness evaluate female Increasing Infection IQR median age of BNT162b2 omicron outcome pediatric Pfizer-BioNTech platform receive SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 testing symptomatic symptomatic infection symptomatic SARS-CoV-2 infection Testing the SARS-CoV-2 Trial vaccination Vaccine variant variants waned was reduced was used white [DOI] 10.1001/jama.2022.7493 PMC 바로가기
Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine재조합 식물 기반 면역증강제 코로나19 백신의 효능 및 안전성Clinical Trial Published on 2022-06-022022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 1:1 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adverse event age Analysis AS03 assigned baseline candidate vaccine caused conducted coronavirus coronavirus disease Coronavirus disease 2019 CoVLP CoVLP+AS03 determine disease dose effective Efficacy Factor FIVE incidence injection intention-to-treat intention-to-treat population Intramuscular injection Local median age Median viral load Medicago Mild moderate occurred participant Participants participated Particle performed Phase 3 Placebo placebo group placebo-controlled trial plant plants polymerase post-hoc analysis prefusion produced Randomized receive recombinant respiratory Safety SARS-CoV-2 sequenced Sequencing seronegative severe acute respiratory syndrome Coronavirus Severe case Spectrum spike glycoprotein symptomatic symptomatic COVID-19 symptomatic infection System systemic adverse event systemic adverse events the median the placebo group the vaccine Trial two group two groups Vaccine vaccine efficacy vaccine group variant variants Viral Viral load viral sample Volunteer [DOI] 10.1056/NEJMoa2201300 PMC 바로가기 [Article Type] Clinical Trial
Cellular and Humoral Immunity to SARS-CoV-2 Infection in Multiple Sclerosis Patients on Ocrelizumab and Other Disease-Modifying Therapies: A Multi-Ethnic Observational StudyOcrelizumab 및 기타 질병 수정 요법을 사용하는 다발성 경화증 환자의 SARS-CoV-2 감염에 대한 세포 및 체액 면역: 다민족 관찰 연구Observational Study Published on 2022-06-012022-09-11 Journal: Annals of neurology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] age ANN antibody Antibody Response Antibody responses assays association Asymptomatic cellular Cellular and humoral immunity Cellular and humoral responses Cellular immune response chemiluminescence immunoassay Clinical course Clinical severity coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 determine domain Effect ELISA ELISPOT ELISpot assays enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated Evidence evidence of group Hospitalized humoral Humoral and cellular immune responses Humoral immunity Humoral response humoral responses IFNγ IL-2 immune responses immunoassay immunologic response immunologic responses Infection Laboratory Live virus microneutralization MOST Multiple multiple sclerosis multivariate analyses Multivariate analysis N-terminal domain Natalizumab not differ Ocrelizumab Other Patient performed Protein RBD receptor recruited respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sclerosis Severe acute respiratory syndrome severity Spearman sphingosine spike Spike protein symptomatic infection T-cell Response T-cell responses therapy with COVID-19 [DOI] 10.1002/ana.26346 PMC 바로가기 [Article Type] Observational Study
Implication of the emergence of the delta (B.1.617.2) variants on vaccine effectiveness백신 효과에 대한 델타(B.1.617.2) 변이체의 출현의 의미Review Published on 2022-06-012022-09-11 Journal: Infection [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered analyzed article assist AstraZeneca B.1.617.2 breakthrough infections concern convalescent patient Convalescent patients COVID-19 COVID-19 vaccine COVID-19 vaccines death Delta delta variant Delta variants determine disease severity effective Effectiveness Efficacy FIVE Hospitalization in vitro in vivo incidence infection with SARS-CoV-2 Meta-analysis Moderna neutralization neutralizing antibody Oxford-AstraZeneca pandemic Pfizer Pfizer-BioNTech reduced reducing reductions in SARS-CoV-2 SARS-CoV-2 pandemic screened searched second dose significant reductions significantly symptomatic infection Transmission vaccinated individual vaccinated individuals vaccination Vaccinations Vaccine Vaccines variant variants [DOI] 10.1007/s15010-022-01759-1 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infections in mRNA vaccinated individuals are biased for viruses encoding spike E484K and associated with reduced infectious virus loads that correlate with respiratory antiviral IgG levelsmRNA 백신을 접종한 개인의 SARS-CoV-2 감염은 스파이크 E484K를 인코딩하는 바이러스에 대해 편향되어 있으며 호흡기 항바이러스성 IgG 수준과 상관관계가 있는 감소된 감염성 바이러스 부하와 관련이 있습니다.Article Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] A significant reduction accompanied Alpha Alpha variant Amino acid Analysis Anti-viral Antiviral association B.1.1.7 B.1.526 BNT162b2 Breakthrough infection breakthrough infections caused Cell culture change Cohort collected COVID-19 cycle threshold dose E484K early phase ELISA examined Genome ICU admission IgG IgG level IgG levels immunization increase in Infectious virus investigated Lineage Moderna molecular Mortality mRNA mRNA-1273 PCR Pfizer-BioNTech positive positive sample Positive test predominant Protein reduce reduced required respiratory respiratory sample Respiratory samples Sample SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 positive patient sequenced Sequencing specimen specimens spike Spike protein symptomatic infection symptomatic infections upper respiratory tract vaccinated individual vaccinated individuals vaccination Vaccines variant Viral Viral load viral loads viral variant virus were used whole genome [DOI] 10.1016/j.jcv.2022.105151 PMC 바로가기 [Article Type] Article
Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathologyCOVID-19 관련 세포 면역 병리학에서 sMAdCAM 및 IL-15의 반대 역할Article Published on 2022-06-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Activation Adhesion Molecule association Asymptomatic Asymptomatic cases CD4+ CD8 Cell cell adhesion molecule cellular characterized circulating Cohort correlated COVID COVID-19 COVID-19 pathology cytokine disease Disease progression duration of hospitalization dysfunction dysregulation effector memory ELISA evaluated Factors flow cytometry Frequency healthy control healthy controls homeostasis homeostatic hypoxemic IL-15 IL-6 IL-6 level IL-6 levels immune increase in India infected individuals Inflammatory factor inflammatory factors intermediate monocytes involved lymphocyte lymphopenia marker Mild moderate moderate to severe monocyte Monocytes mucosal multiparametric flow cytometry Mumbai Pathogenesis pathology plasma profiles quantified recruited regulatory T cells SARS-CoV-2 SARS-CoV-2 infected individual SARS-CoV-2 infected individuals severe disease sMAdCAM. Stage subset symptomatic individual symptomatic individuals symptomatic infection T cells was used while [DOI] 10.1002/JLB.3COVBCR0621-300R PMC 바로가기 [Article Type] Article
A country-specific model of COVID-19 vaccination coverage needed for herd immunity in adult only or population wide vaccination programme성인 전용 또는 전체 인구 백신 프로그램에서 집단 면역에 필요한 국가별 COVID-19 예방 접종 범위 모델Article Published on 2022-06-012022-09-11 Journal: Epidemics [Category] 변종, [키워드] addition Adults age Age structure booster calculate Care children Contact country Coverage COVID-19 vaccination demographics effective Effectiveness extension Herd herd immunity Immunity Impact IMPROVE Infection Measures Next generation matrix population level pre-vaccination proportion relative infectivity reproduction Reproduction number required Seroprevalence susceptibility symptomatic infection symptomatic infections vaccination Vaccine variant [DOI] 10.1016/j.epidem.2022.100581 PMC 바로가기 [Article Type] Article
Seroprevalence of SARS-CoV-2 infection and associated factors among Bangladeshi slum and non-slum dwellers in pre-COVID-19 vaccination era: October 2020 to February 2021COVID-19 예방 접종 이전 시대의 방글라데시 슬럼가와 비슬럼 거주자 사이의 SARS-CoV-2 감염 및 관련 요인: 2020년 10월 ~ 2021년 2월Article Published on 2022-05-232022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 1.26 95% CI acute respiratory syndrome adjusted odds ratio Adults association Asymptomatic BCG vaccination Blood blood pressure carried children chronic conditions Community confidence interval coronavirus country cross-sectional determine diabete disease evaluate Factor immunoassay Infection information Mask offer participant Population Probability Roche SARS-CoV-2 SARS-COV-2 infection serology Seroprevalence symptomatic infection vaccination washing hand washing hands [DOI] 10.1371/journal.pone.0268093 PMC 바로가기 [Article Type] Article
Protective effect conferred by prior infection and vaccination on COVID-19 in a healthcare worker cohort in South India인도 남부의 의료 종사자 집단에서 COVID-19에 대한 사전 감염 및 예방 접종에 의해 부여된 보호 효과Article Published on 2022-05-202022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI absence Cohort covariate COVID-19 COVID-19 disease Cox proportional hazard Cox proportional hazards model delta variant dose Efficacy examined HCW Health care health care workers healthcare worker Healthcare workers Immune escape incidence Infection infection rate infection rates offered proportional hazards model Protective protective effect provided raise Re-infection Re-infections reported resulting RT-PCR second wave severe disease south India symptomatic symptomatic infection tested vaccination Vaccine vaccine efficacy variant were infected [DOI] 10.1371/journal.pone.0268797 PMC 바로가기 [Article Type] Article
Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar카타르에서 SARS-CoV-2 오미크론 감염에 대한 mRNA 백신 부스터의 효과Article Published on 2022-05-122022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 association B.1.1.529 B.1.617.2 BNT162b2 booster booster dose booster doses booster vaccination Cohort cohorts conducted coronavirus coronavirus disease Coronavirus disease 2019 cumulative cumulative incidence death dose Effect effective Effectiveness effort Follow-up Hospitalization incidence Infection less Messenger RNA Moderna mRNA mRNA-1273 mRNA-1273 vaccine of BNT162b2 omicron Pfizer-BioNTech protection regression models retrospective cohort study SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus symptomatic symptomatic infection symptomatic SARS-CoV-2 infection Vaccine variant variants with infection [DOI] 10.1056/NEJMoa2200797 PMC 바로가기 [Article Type] Article