target protein – Page 4 – Communicable Diseases Research

In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation

분자 도킹 시뮬레이션을 사용한 SARS-CoV-2의 잠재적 억제제로서의 천연물 스크리닝

Article

Published on 2022-03-012022-09-11
Journal: Chinese journal of integrative medicine [Category] SARS, 치료제,

Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies

코로나19 예방 및 치료에 있어서 프로폴리스와 꿀의 잠재적 효과: in silico 및 임상 연구에 대한 체계적인 검토

Review

Published on 2022-03-012022-09-11
Journal: Journal of integrative medicine [Category] SARS, 임상, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant therapy angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Case report case reports Case series case sery clinical evidence Clinical improvement Clinical studies clinical study clinical symptom Clinical symptoms Cochrane Library Compound concerning conducted controlled trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptom data extraction database decrease disease Effect enzyme evaluated Evidence Future Honey IMPROVE in silico In silico methods independent indicated Infection mechanism Mild moderate-to-severe COVID-19 patients molecular docking narrative Patient positive Potential potential mechanism Propolis protease Randomized controlled trial RCT RCTs Replication RNA-dependent RNA polymerase sample sizes SARS-CoV-2 severe acute respiratory syndrome Coronavirus silico studies silico study Spike protein Standard of care standardized data extraction systematic review target protein target proteins therapy Treatment viral clearance viral entry Viral RNA was used were used
[DOI] 10.1016/j.joim.2022.01.008 PMC 바로가기 [Article Type] Review

Structure- and Interaction-Based Design of Anti-SARS-CoV-2 Aptamers

Anti-SARS-CoV-2 앱타머의 구조 및 상호 작용 기반 설계

Article

Published on 2022-02-242022-09-11
Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID19(2023년), SARS, 변종,

[키워드] approach aptamer Aptamers binding binding affinity blueprint complexes computational method Computational methods Cytometry develop Directed mutagenesis DNA docking drug design ENhance fragment molecular orbitals method functional IMPROVE in silico Infection Interaction iterative methodology molecular molecular docking molecular dynamics molecules Mutagenesis nucleic acids offer pathogen probes Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike protein SAXS scratch speed Spike protein Structure synergy target target protein tertiary structure the receptor-binding domain the SARS-CoV-2 time-consuming variants X-ray scattering
[DOI] 10.1002/chem.202104481 PMC 바로가기 [Article Type] Article

Convalescent Plasma for Preventing Critical Illness in COVID-19: a Phase 2 Trial and Immune Profile

COVID-19의 중병 예방을 위한 회복기 혈장: 2상 시험 및 면역 프로필

Clinical Trial

Published on 2022-02-232022-09-10
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] 28-day mortality 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration Admission Alter anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies antibody Antibody Response Antibody titers Antiviral effect antiviral effects baseline caused circulating co-morbidities co-morbidity comparable Confirmed COVID-19 infection Control controls convalescent plasma coronavirus COVID-19 COVID-19 infection COVID-19 pandemic Critical Critical illness Critically ill death demographics Dexamethasone group hazard ratio Hospital admission ICU IgA level illness immune initial Level morbidities non-critically ill patient non-critically ill patients non-ICU pandemic Pandemics participant Patient PCR Phase 2 Planning plasma populations Preventing profile progression provide reduce reduced reduction in Remdesivir respiratory Respiratory disease Respiratory failure respiratory symptom respiratory symptoms respiratory tract SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly increased single-arm specific antibody statistically significant difference suggestion target protein target proteins tested transfer transfused transfusion Treatment Trial with COVID-19
[DOI] 10.1128/spectrum.02560-21 PMC 바로가기 [Article Type] Clinical Trial

Discovery of novel TMPRSS2 inhibitors for COVID-19 using in silico fragment-based drug design, molecular docking, molecular dynamics, and quantum mechanics studies

Research article

Published on 2022-02-022022-10-05
Journal: Informatics in Medicine Unlocked [Category] 신약개발,

In silico screening of potent inhibitors against COVID-19 key targets from a library of FDA-approved drugs

FDA 승인 약물 라이브러리에서 Covid-19 핵심 목표에 대한 강력한 억제제의 실리코 스크리닝에서

Article

Published on 2022-02-012022-08-31
Journal: Environmental science and pollution research inter [Category] COVID19(2023년), MERS, SARS, 신약개발, 치료제,

[키워드] Analysis angiotensin Angiotensin II Angiotensin receptor blockers Antibiotics antihypertensive approval assigned binding blocker Cell coronavirus coronavirus disease COVID-19 development disease drug Drug repurposing Efficacy exhibited FDA-approved drug FDA-approved drugs Heartburn inhibitor Interference library life cycle molecular docking molecular target oral Oral antiseptics. OTC Other pandemic pathway Polymyxin B Protein receptor rifampicin screened severity of COVID-19 specific proteins stability Stage target target protein target proteins tested therapeutic therapeutic purpose Vaccine virus Virus life cycle
[DOI] 10.1007/s11356-021-16427-4 PMC 바로가기 [Article Type] Article

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

Remdesivir, Molnupiravir 및 Nirmatrelvir는 SARS-Cov-2 Omicron 및 기타 변형에 대해 계속 활성화되어 있습니다.

Article

Published on 2022-02-012022-09-10
Journal: Antiviral Research [Category] 변종, 치료제,

[키워드] active against Alpha Antiviral antiviral activity antivirals Beta Cell Compound conserved Delta delta variant Delta variants determined by EIDD-1931 FIVE Gamma GFP GS-441524 high-content imaging Highlights in vitro Infection molnupiravir MPro Nirmatrelvir nucleoside observation omicron other variant parent nucleoside Post-infection protease Protease inhibitor Remdesivir RNA polymerase SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV2 serial dilution serial dilutions susceptible target gene Target genes target protein target proteins variants variants of concern Viral Viral RNA virus VoC was determined
[DOI] 10.1016/j.antiviral.2022.105252 PMC 바로가기 [Article Type] Article

Designing of peptide aptamer targeting the receptor-binding domain of spike protein of SARS-CoV-2: an in silico study

SARS-CoV-2의 스파이크 단백질 수용체 결합 도메인을 표적으로 하는 펩타이드 앱타머 설계: in silico 연구

Article

Published on 2022-02-012022-09-11
Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료법, 치료제,

[키워드] ACE2 albumin antibodies approach aptamer ATP Bacterial bind CD4 complex coronavirus docked domain ENCODE envelope Genome high affinity host cell in silico membrane metal ions molecular molecular docking molecular dynamic simulation monoclonal antibodies non-allergenic non-hemolytic nucleocapsid peptide Peptide aptamer predicted Protein Proteins Receptor-binding domain SARS-CoV-2 scaffold protein serum albumin specificity spike Spike protein spike receptor-binding domain stability target target protein tertiary structure the receptor-binding domain theophylline Therapeutic treatment thioredoxin thrombin virus
[DOI] 10.1007/s11030-020-10171-6 PMC 바로가기 [Article Type] Article

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

Article

Published on 2022-02-012022-10-27
Journal: Antiviral Research [Category] COVID-19,

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

Article

Published on 2022-02-012022-10-27
Journal: Antiviral Research [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, SARS,