Antineoplastic treatment class modulates COVID-19 mRNA-BNT162b2 vaccine immunogenicity in cancer patients: a secondary analysis of the prospective Vax-On study항암제 치료 클래스는 암 환자에서 COVID-19 mRNA-BNT162b2 백신 면역원성을 조절합니다: 전향적 Vax-On 연구의 2차 분석Article Published on 2022-02-012022-09-12 Journal: ESMO open [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] accounted Analysis antibody Antibody Response Antineoplastic Cancer cancer treatment carried Chemotherapy classification Cooperative correlated correlation Corticosteroid COVID-19 COVID-19 vaccination COVID-19 vaccine Cytotoxic chemotherapy defined DNA dose drug Effect enrolled granulocyte group humoral IgG Immunoglobulin immunosuppressive inhibitor inhibitors Interaction intravesical lack modulate mTOR inhibitor Patient performance status predicted Rapamycin Receptor binding domain reduced retained second dose Seroconversion seroconversion response significantly significantly lower Specific Spike protein subgroup subgroup analysis subgroups targeted therapy the S1 subunit the SARS-CoV-2 therapy TKI TKIs treated Treatment tyrosine kinase inhibitor Vaccine vaccine immunogenicity Variation [DOI] 10.1016/j.esmoop.2021.100350 PMC 바로가기 [Article Type] Article
Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers일본 인구에서 SARS-CoV2 감염에 대한 다양한 종류의 항체 반응 역학: IgA 및 IgG 역가가 IgM 역가보다 일찍 증가했습니다.Article Published on 2022-02-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody responses Asian association Clinical course clinical feature Clinical features coronavirus COVID-19 domain IgA IgA antibodies IgA antibody IgG IgG response IgG responses IgG titer IgM IgM and IgG IgM responses IgM seroconversion IgM/IgG immune response immune responses individuals with COVID-19 Infection Japanese Japanese population Kinetics Kinetics of antibody responses less Mild nucleocapsid protein occurred Patient Population populations Protein RBD Receptor-binding domain respiratory response S1 subunit SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV2 infection Seroconversion serum titer serum titers severe acute respiratory syndrome Coronavirus spike Spike protein spread of COVID-19 sustained the antibody response the S1 subunit the spike protein timeline Viral protein Viral proteins [DOI] 10.1016/j.intimp.2021.108491 PMC 바로가기 [Article Type] Article
Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infectionSARS-CoV-2 스파이크 단백질에 대한 항체 반응의 포괄적인 특성화는 경증 감염에 대한 것 이외의 추가 백신 유도 에피토프를 찾습니다.Comparative Study Published on 2022-01-242022-09-10 Journal: eLife [Category] 변종, 치료기술, 치료제, [키워드] Affect affected age Alter Analysis antibodies antibody Antibody binding antibody epitope Antibody Response Antigen Bacteria binding C-terminal domain cause chair changes in complicate Comprehensive computing conserved Control covariate COVID-19 COVID-19 pandemic disease DNA fragment dose education effective epitope Epitopes escape escape mutations experiment exposure to faculty FAM feature finding focus foundation funding fusion peptide genetic code help Howard Hughe Howard Hughes Human Humoral response humoral responses identify immune Immune escape immune system implication individual infect infected individuals Infection Infrastructure interfere Laboratory Lower majority mild infection mRNA vaccination mRNA vaccine mutant Mutation mutations NIH not affect not altered occur offered overlapping pandemic pathway Pathways pattern peptide peptides phage phages population level portion Principal component principal component analysis produced producing PROTECT Protein RBD Region regions Research residue route S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Scholar selected severe disease Severe infection shape small molecule Small molecules specific antibodies specific protein spike Spike protein spike-specific antibodies Spike-specific antibody Spread stick subsequent Support supported target the antibody the antibody response the RBD the S1 subunit the SARS-CoV-2 the Spike the spike protein thought triggering unique vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development vaccine-induced antibodies vaccine-induced antibody variant Variation virus was performed while wild-type [DOI] 10.7554/eLife.73490 PMC 바로가기 [Article Type] Comparative Study
Penetration of the SARS-CoV-2 Spike Protein across the Blood–Brain Barrier, as Revealed by a Combination of a Human Cell Culture Model System and Optical BiosensingArticle Published on 2022-01-172022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] barrier biosensor Brain Caco-2 cells caused cell layer circulation consequence coronavirus spike protein cross demonstrated disseminate ELISAs Endothelial cell evaluate global pandemic Human human brain endothelial cell in vitro Infection Integrated optics intestinal investigated Mach–Zehnder interferometer mechanism mice Model model system Neuroinflammation Neuroinvasive Neurological symptom observation optical organ outbreak penetration permeability Respiratory Coronavirus Respiratory system Revealed route of infection SARS-CoV-2 spike Spike protein System the disease the S1 subunit the SARS-CoV-2 tissue barriers viral spike protein [DOI] 10.3390/biomedicines10010188 PMC 바로가기 [Article Type] Article
Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries대규모 합성 파지 라이브러리에서 다양한 중화 SARS-CoV-2 항체의 신속한 발견Article Published on 2022-01-012022-09-11 Journal: mAbs [Category] 변종, 진단, [키워드] Alpha antibody Beta bind binding candidate characterization complementarity-determining region coronavirus disease Coronavirus disease 2019 COVID-19 Delta disease epitope Features Gamma global public health Health crisis high affinity IgG in vitro in vivo limit mAbs monoclonal antibodies monoclonal antibody N-terminal domain Neutralizing Neutralizing activity neutralizing antibody neutralizing SARS-CoV-2 antibody passive immunization Rapid Receptor-binding domain retained S1 subunit SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants spike glycoprotein Spike protein synthetic libraries synthetic libraries. the receptor-binding domain the S1 subunit therapeutic options therapeutic strategy unique while [DOI] 10.1080/19420862.2021.2002236 PMC 바로가기 [Article Type] Article
Decline of antibody titres 3 months after two doses of BNT162b2 in non-immunocompromised adults면역 저하가 없는 성인에서 BNT162b2 2회 투여 후 3개월 후 항체 역가 감소Observational Study Published on 2022-01-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] 임상, 진단, [키워드] acute respiratory syndrome age Analysis anti-RBD Anti-RBD antibodies Anti-RBD antibody Antibody titre BNT162b2 collected conditions coronavirus COVID-19 Decline declined dose first dose hospital Humoral immunity immunoassay Immunocompromised immunogenicity interquartile range maintain male marker median mild SARS-CoV-2 infection Neutralizing activity of BNT162b2 participant Prospective Quantitative raise receiving Receptor binding domain required SARS-CoV-2 second dose serum serum sample short-lived the antibody response the S1 subunit the spike protein threshold titre vaccination Vaccine was used were excluded were measured [DOI] 10.1016/j.cmi.2021.08.023 PMC 바로가기 [Article Type] Observational Study
Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for PathogenicityArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 air–liquid interface Alpha Altered alveolar Analysis anti-viral response bronchial bronchial epithelial cell canonical cell membrane coronavirus COVID-19 COVID-19 vaccines cytokine differentially regulated gene Effect enzyme exposure to expression fibrosis host cell receptor Human IFN IFNγ IL10 IL12 IL13 IL2 IL4 IL6 IL8 Infection Influenza integrin interferon Ligand lung Lung fibrosis MERS (middle east respiratory syndrome) mRNA-based mucosa Mutation Necrosis neutralizing antibody p53 pathogenicity pathway platform pro-fibrotic pro-inflammatory cytokine pulmonary receptor Receptor binding domain Recombinant S1 protein regions robust S1 protein S1 subunit SARS (severe acute respiratory syndrome) SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant secreted Signaling significantly spike spike glycoprotein Spike protein the S1 subunit TLR TLR4 Type II pneumocyte virus [DOI] 10.3390/v13122537 PMC 바로가기 [Article Type] Article
A vesicular stomatitis virus-based prime-boost vaccination strategy induces potent and protective neutralizing antibodies against SARS-CoV-2수포성 구내염 바이러스 기반 프라임-부스트 백신 접종 전략은 SARS-CoV-2에 대한 강력하고 보호적인 중화 항체를 유도합니다Research Article Published on 2021-12-162022-09-12 Journal: PLoS Pathogens [Category] SARS, 진단, [키워드] Adding avirulent chimeric COVID-19 COVID-19 pandemic COVID-19 vaccine cytoplasmic tail demonstrated derivative develop effective effective vaccine expressed expression form full-length full-length spike protein G protein Genome hallmark Health help highest immune system immunization immunized mice induce infections lung damage majority N-terminus Neutralizing antibodies neutralizing antibody pandemic peptide Prevent Protective protective neutralizing antibody Protein protein expression pseudotype RBD Receptor-binding domain recognize reduced resulting S1 subunit Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 protein SARS-CoV-2 spike proteins signal peptide significantly Spike protein stomatitis strain subsequent T cell T cell responses the receptor-binding domain the S1 subunit transmembrane domain Vaccinating Vaccination strategy Vaccine Vaccines variants of concern vesicular stomatitis vesicular stomatitis virus viral disease Viral diseases VSV [DOI] 10.1371/journal.ppat.1010092 PMC 바로가기 [Article Type] Research Article
Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiationArticle Published on 2021-12-032022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] body temperature cause Chemical biology comparable COVID-19 denaturation Effect eliminating facilitate host cell intensity Microbiology Protein Radiation SARS-CoV-2 Spike protein temperature the S1 subunit the SARS-CoV-2 therapeutic viral entry virus was performed widespread [DOI] 10.1038/s41598-021-02753-7 PMC 바로가기 [Article Type] Article
Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine inductionResearch Article Published on 2021-11-182022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] ACE2 angiotensin-converting enzyme 2 antibodies Antiviral antiviral activity approach binding binding affinity cell entry Contact crystal structure demonstrated Effect experiment expressing glycoprotein high affinity host cell human cell Inflammation inhibiting inhibitor Interaction linear majority membrane nanobody neutralisation assay peptide peptides pro-inflammatory cytokine RBM Receptor binding domain receptor binding motif residue responsible S RBD SARS-CoV-2 SARS-CoV-2 viral selected sequence soluble ACE2 Spike protein suggested suppress the S1 subunit the SARS-CoV-2 the spike protein to define trimer viral cell viral spike viral spike protein virulence [DOI] 10.1371/journal.pone.0260283 PMC 바로가기 [Article Type] Research Article