Estimating the Neutralizing Effect and Titer Correlation of Semi-Quantitative Anti-SARS-CoV-2 Antibody Immunoassays반정량적 항SARS-CoV-2 항체 면역분석법의 중화 효과 및 역가 상관관계 추정Article Published on 2022-04-142022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Anti-RBD IgG anti-SARS-CoV-2 antibody antibodies antibody Antibody responses antibody tests assays best Chemiluminescent assay comparable convalescent phase correlated correlation COVID-19 cut-off Effect evaluated IgG antibodies IgG antibody immunoassay infections investigated linear linear correlation neutralization test Neutralizing Neutralizing activity neutralizing antibody nucleocapsid protein nucleopcapsid (NP) protein Pearson plaque reduction neutralization Plaque reduction neutralization test PRNT Protein RBD Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection semi-quantitative sensitivity serology specificity spike (S) protein Spike protein sVNT the RBD the receptor-binding domain the spike protein titer total antibodies total antibody virus neutralization test [DOI] 10.3389/fcimb.2022.822599 PMC 바로가기 [Article Type] Article
High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease SeverityCOVID-19 환자에서 낮은 친화도 항체의 높은 역가는 질병 중증도와 관련이 있습니다Article Published on 2022-04-132022-09-12 Journal: Frontiers in Immunology [Category] Coronavirus, COVID19(2023년), SARS, 진단, [키워드] addition Affect affinity analyzed antibodies antibody production Antibody Response Antibody titer Antigen association binding clinical information coronavirus disease COVID COVID-19 COVID-19 patient Critically ill critically ill patients disease Disease progression disease severity domain epitope mapping humoral IgA IgA antibody IgG IgG antibody titer IgM immunoassay Infectious diseases Interaction investigated isotype material maturation pandemic Patient peptide positive Prognostic marker Protein Proteins RBD SARS-CoV2 sera severity specific antibody SPRi (surface plasmon resonance imagery) the RBD titer viral infection [DOI] 10.3389/fimmu.2022.867716 PMC 바로가기 [Article Type] Article
Reduced COVID-19 mortality linked with early antibodies against SARS-CoV-2, irrespective of age연령에 관계없이 SARS-CoV-2에 대한 조기 항체와 연결된 COVID-19 사망률 감소Article Published on 2022-04-012022-09-11 Journal: European journal of internal medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료법, [키워드] Admission advanced age age Anti-spike antibody Antibody Response clinical assessment Clinical outcome co-morbidity Concentration COVID-19 COVID-19 infection COVID-19 mortality COVID-19 pandemic Cox regression model Critical death died discharged disease severity early phase early stage Efficiency elderly Elderly patient elderly patients functional healing hospital Hospital stay Hospitalization Humoral immunity IgG IgG levels IgM immune system Immunological response In-hospital death indicated lymphopenia modulate Mortality multivariate Multivariate Cox regression models Older outcome outcomes Patient produced PROTECT Protein risk risk factor SARS-CoV-2 serum Serum level serum levels stratified subject subjects therapeutic strategy titer [DOI] 10.1016/j.ejim.2022.02.010 PMC 바로가기 [Article Type] Article
Higher Proinflammatory Cytokines Are Associated With Increased Antibody Titer After a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients고형 장기 이식 수혜자에게 SARS-CoV-2 백신 3차 접종 후 더 높은 전염증성 사이토카인이 증가된 항체 역가와 관련이 있습니다Article Published on 2022-04-012022-09-11 Journal: Transplantation [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody Antibody Response baseline chemokine Concentration cross-sectional cross-sectional study cytokine cytokine level Cytokines detectable determine develop dose Electrochemiluminescence elevated ELISA false discovery rate HCs healthy control IgG IL-17 IL-6 immunoassay Increased increased risk Inflammatory innate immune IP-10 MIP-1α mRNA vaccine Multiple multiple comparisons no significant difference Plasma cytokine prevaccination recipient responders SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines scale severe COVID-19 significantly higher Solid solid organ stratified study population the vaccine titer TNF-α Transplant Vaccine vaccine dose was performed were used [DOI] 10.1097/TP.0000000000004057 PMC 바로가기 [Article Type] Article
Differential Anti-S Antibody Titers in Vaccinated Residents During an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant B.1.351 (β) in an Elderly Nursing Home노인 요양원에서 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 변이체 B.1.351(β) 발병 시 예방접종을 받은 거주자의 차등 항-S 항체 역가Article Published on 2022-03-232022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] B.1.351 coronavirus 2 elderly home Nursing resident respiratory SARS-CoV-2 titer [DOI] 10.1093/cid/ciab676 PMC 바로가기 [Article Type] Article
Assessment of anti-SARS-CoV-2 antibodies level in convalescents plasma회복기 혈장에서 항-SARS-CoV-2 항체 수준 평가Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 변종, 진단, [키워드] age anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody antibody assessment average average age Blood donors convalescent convalescent plasma Course COVID-19 COVID-19 infection cross-sectional determine Donor epidemiological Factors geographical region IgG antibodies increase increase in Infection levels of antibody men men and women Patient plasma Poland quantity questionnaire SARS-CoV-2 SARS-CoV-2 virus Severe infection severity significantly higher statistically study group the antibody the disease the SARS-CoV-2 virus therapy These data titer treating Treatment vaccination variant women [DOI] 10.1002/jmv.27433 PMC 바로가기 [Article Type] Article
Previous SARS-CoV-2 Infection, Age, and Frailty Are Associated With 6-Month Vaccine-Induced Anti-Spike Antibody Titer in Nursing Home Residents이전 SARS-CoV-2 감염, 연령 및 노쇠는 요양원 거주자의 6개월 백신 유도 항스파이크 항체 역가와 관련이 있습니다Article Published on 2022-03-012022-09-11 Journal: Journal of the American Medical Directors Associat [Category] MERS, SARS, 진단, 치료법, [키워드] 95% confidence interval ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age All participant All participants analyzed angiotensin Angiotensin-converting enzyme Anti-spike anti-spike antibody antibody Antibody Response Antibody titer Antibody titers BNT162b2 Clinical outcome clinical outcomes cohort study Comorbidity Comprehensive coronavirus correlated COVID-19 demonstrated determinant determinants Evidence evidence of examined female frailty home in vitro independent of Infection log-transformed Long-term care longitudinal longitudinal cohort study make up Messenger RNA morbidity morbidity and mortality naïve Neutralization assay neutralization capacity nucleocapsid Nursing nursing home nursing homes Older participant post vaccination RBD receptor Receptor binding domain resident respiratory risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2.0 Serum Neutralization setting severe acute respiratory syndrome Coronavirus significantly significantly lower the strongest timepoints titer vaccination Vaccine vulnerable population was performed [DOI] 10.1016/j.jamda.2021.12.001 PMC 바로가기 [Article Type] Article
Serial Changes of Long COVID Symptoms and Clinical Utility of Serum Antibody Titers for Evaluation of Long COVIDArticle Published on 2022-02-272022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute phase Affect Anti-SARS-CoV2 antibody Antibody titer change changes in clinical Clinical course COVID determine dysgeusia dysosmia examined general fatigue headache Hospitalization improvement Infection initial Japan key factor Long Long COVID malaise medical record outpatient clinic Patient patients patients with COVID-19 persistence required Retrospective analysis SARS-CoV-2 antibody serum antibody significantly sleeplessness Symptom Symptoms the patient therapy titer Treatment university university hospital was obtained was performed [DOI] 10.3390/jcm11051309 PMC 바로가기 [Article Type] Article
Long-Term Persistence of Anti-SARS-COV-2 IgG Antibodies항-SARS-COV-2 IgG 항체의 장기간 지속성Article Published on 2022-02-122022-09-11 Journal: Current microbiology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody assays automated automated analyzer C-reactive protein collected Coronavirus-2 correlation decrease detectable determine Diseases evaluate evaluated Evidence evidence of FIVE Follow-up highest hospitalized patient IgG IgG and IgM IgG antibody IgM antibodies Infection lymphocyte Mild moderate neutrophil Neutrophil-to-lymphocyte ratio NLR no significant difference no significant differences onset of symptom Patient patients with COVID-19 PCR-confirmed persistence POS Real-time PCR recovered COVID-19 patient Recovered COVID-19 patients respiratory SARS-CoV-2 infections Serum level serum levels serum sample serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Severity of disease significant differences significantly stability the immunoassay the mean titer [DOI] 10.1007/s00284-022-02800-0 PMC 바로가기 [Article Type] Article
Immunogenicity and Safety of the BNT162b2 mRNA COVID-19 Vaccine Among Actively Treated Cancer Patients적극적으로 치료받는 암 환자 중 BNT162b2 mRNA COVID-19 백신의 면역원성과 안전성Article Published on 2022-02-072022-09-12 Journal: Journal of the National Cancer Institute [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activity Adults adverse effect antibody Antibody titer anticancer BNT162b2 mRNA BNT162b2 vaccine Cancer cancer patient Chemotherapy combinations conducted control group COVID-19 Cutoff determine dose effective greater healthy immune Immune checkpoint inhibitor immunogenicity Immunoglobulin measure medication MOST Patient patients Patients with cancer proportion Protective questionnaire reported Retrospective study Safe Safety SARS-CoV-2 seronegative seropositive Side effect significantly significantly lower solid tumor statistical test statistically targeted therapy the SARS-CoV-2 titer treated treated patient Treatment vaccination Vaccine was collected were measured [DOI] 10.1093/jnci/djab174 PMC 바로가기 [Article Type] Article