Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans박테리아 대사 산물에 의한 화학 감각 뉴런 유전자 발현의 즉각적인 활성화는 Caenorhabditis elegans에서 별개의 순환 GMP 의존 경로에 의해 선택적으로 유도됩니다Research Article Published on 2020-08-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation addition animals Author avoidance bacterial metabolite Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans calcium canonical cGMP chemosensory cyclic GMP dependent on detect dissect dynamic elegan elegans engage expression external environment gene encoding Gene Expression highlighting Immediate induce intracellular signaling lead Ligand mechanism metabolite metabolites microbial modulate nervous system neuroendocrine Neuron neuronal neurons P . aeruginosa pair pathogen pathogenic pathogenic bacteria pathogenic bacterium pathway produced Protective Protein protein kinase Pseudomonas aeruginosa required response selective sensation sensory neuron sensory neurons Signal transduction Signaling signaling pathway subunit TGF-β Transcription transcriptional transcriptional response turn [DOI] 10.1371/journal.pgen.1008505 PMC 바로가기 [Article Type] Research Article
Isolation, social stress, low socioeconomic status and its relationship to immune response in Covid-19 pandemic contextReview article Published on 2020-08-012022-10-05 Journal: Brain, Behavior, & Immunity - Health [Category] 유전자 메커니즘, [키워드] Activation Anti-viral Characteristics chronic condition conserved Conserved transcriptional response to adversity (CTRA) Contact coronavirus disease COVID-19 CTRA defend Gene Expression Government Health Hormones Human immune response immune system Injury Isolation measure mitigate molecular morbidity and mortality organism outbreak pandemic physical predatory pro-inflammatory gene expression professional question raise reported researcher risk Social disruption stress Sociogenomics Spread Stress Stress hormones thought transcriptional transcriptional response viral infections Wuhan, China [DOI] 10.1016/j.bbih.2020.100103 [Article Type] Review article
Transcriptional response of USP18 predicts treatment outcomes of interferon-alpha in HBeAg-positive chronic hepatitis B patientsefereArticle Published on 2019-09-012023-06-19 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Chronic Hepatitis B interferon-alpha transcriptional response Treatment outcome ubiquitin-specific protease 18. [DOI] 10.1111/jvh.13120 PMC 바로가기
The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C . elegans핵 호르몬 수용체 NHR-86은 C에서 항병원체 반응을 조절한다. 엘레강스Research Article Published on 2019-01-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation adaptive analysis Author bacterial pathogen baseline bind biological function canonical characterized chromatin chromatin immunoprecipitation Control determine Drosophila effector elegan elegans exogenous ligands experiments family function Genetic genetic screen Genome homolog hormone receptor hormone receptors host response Human immune immune activation immunostimulatory induce Infection innate immune activation majority MAPK modulate nuclear pathogen pathway PMK-1 positioned promoter promoters Protective Protein provide Pseudomonas aeruginosa Recognition Regulation required response small molecule target Transcription transcription factor transcription factors transcriptional transcriptional regulator transcriptional response Transcriptome [DOI] 10.1371/journal.pgen.1007935 PMC 바로가기 [Article Type] Research Article
Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine스트레스 반응 및 대사 유전자 조절은 낮은 S-아데노실메티오닌에서 변경됩니다.Research Article Published on 2018-11-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated activating Acute stress affected alcohol analyzed animal animals assays Bacterial Caenorhabditis elegan Caenorhabditis elegans choline chromatin cystic fibrosis deficiencies deficiency disease Disease progression DNA Donor elegan elegans enzyme Enzymes exacerbate expression fibrosis Gene Expression Gene regulation Genes Genetic group Heat shock heat stress histone Histones in some influence less metabolism metabolite methionine methyl groups Methylation Modification modify nucleic acid organism Organisms pathogen Phosphatidylcholine Phospholipids produced Protective provide Reactions reduced Regulation required respond response responses RNA S-adenosylmethionine SAM Stress stress conditions survival tissue injury Transcription transcriptional response transcriptional responses variety [DOI] 10.1371/journal.pgen.1007812 PMC 바로가기 [Article Type] Research Article
Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulationMycobacterium leprae 항원 자극 후 유전자 발현의 유전자 제어 해독Research Article Published on 2017-08-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Affect Antigen bacterium binding site Blood cells caused conducted criteria Differential gene expression disease disease control displaying enrichment eQTL Evidence exposure to expression FDR Gene Expression gene expression level Genetic genetic control Genetic variation Genetic variations genomic highlight Host host genetics host response host responses human host human infectious disease immune Immune cell immune cells Infection Infectious disease Interaction involved knowledge leprosy loci mechanism modulate modulation Mycobacterium leprae natural selection nucleotide outlined pathogen Pathogenesis pathogenicity Patient performed Positive selection proportion Quantitative reaction Regulatory reported Seven significantly Single nucleotide polymorphism single nucleotide polymorphisms SNPs Stimulation suggested susceptibility the disease transcript transcription factor transcription factors transcriptional response triggered upregulation variant variants Variation while whole blood cell whole blood cells [DOI] 10.1371/journal.pgen.1006952 PMC 바로가기 [Article Type] Research Article
Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection3' 번역되지 않은 영역의 광범위한 단축 및 증가된 엑손 포함은 감염에 대한 타고난 면역 반응의 진화적으로 보존된 특징입니다Research Article Published on 2016-09-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ UTR accompanied activated adaptive immune responses Bacteria Bacterial infection Bacterial infections cellular response Cellular responses change changes in characterized collected complementary conserved evade example ExoN expression Factor feature functional Gene Expression Gene regulation human macrophage human macrophages idea identify immune immune response immune responses Inclusion increase in Increased individuals Infection Innate innate immune response innate immune responses involved isoform less Listeria monocytogene Listeria monocytogenes Macrophage macrophages mechanism microRNA miRNAs mRNA non-human primates polyadenylation sites Post-infection pre-mRNA primates reduced Region regulate regulated Regulation repression response RNA Salmonella Typhimurium sequenced Sequencing shortening significantly Support tandem transcriptional response transcriptional responses upstream Usage UTRs Variation while whole blood sample [DOI] 10.1371/journal.pgen.1006338 PMC 바로가기 [Article Type] Research Article
Human Social Genomics인간사회유전체학Review Published on 2014-08-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] analysis antibody antibody synthesis antiviral response cancers characterized condition conserved contribute CTRA decreased expression developmental differential expression everyday life expression functional Functional genomics Gene Expression Genetic Genome genomic Genomics group Health Human human gene Human genome human social genomics increased expression individual well-being innate antiviral responses involved leukocyte leukocytes mapped metastatic cancers pathway proinflammatory gene proinflammatory genes social isolation social status socioeconomic status stimulate tissue transcript transcriptional transcriptional response unique urbanity [DOI] 10.1371/journal.pgen.1004601 PMC 바로가기 [Article Type] Review
Genomic Profiling of Collaborative Cross Founder Mice Infected with Respiratory Viruses Reveals Novel Transcripts and Infection-Related Strain-Specific Gene and Isoform ExpressionMouse Genetic Resources Published on 2014-06-052022-10-31 Journal: G3 (Bethesda, Md.) [Category] Coronavirus, [키워드] acute respiratory syndrome aligned base pair collaborative cross conserved coronavirus differential expression eight elements expression gene transcription Genetic variation Genome genomes genomic host response identify Infection influenza A virus instance isoform isoform differential expression junctions knowledge lung mice mouse transcriptome annotation Mutation novel Profiling proportion recorded respiratory respiratory virus resulting RNA sample RNA-Seq sequence sequenced strain Strains transcribed transcript transcriptional transcriptional profile transcriptional response Transcriptome transcripts unlikely Variation viral infection [DOI] 10.1534/g3.114.011759 PMC 바로가기 [Article Type] Mouse Genetic Resources