Causal Modeling to Mitigate Selection Bias and Unmeasured Confounding in Internet-Based Epidemiology of COVID-19: Model Development and ValidationCOVID-19의 인터넷 기반 역학에서 선택 편향과 측정되지 않은 교란을 완화하기 위한 인과 관계 모델링: 모델 개발 및 검증Article Published on 2022-07-212022-09-11 Journal: JMIR Public Health and Surveillance [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] age applied approach Bia bias Causal Causality collected Community compatibility conditions Confounding confounding factors COVID-19 COVID-19 symptoms Critical cumulative demographic characteristics demographics design detect determine develop development Diagnosis Epidemic epidemiologic research design epidemiological Epidemiological study Epidemiology estimate Health status household infection implementation Infection infection rate internal and external Mechanical mechanism method mitigate Model modeling MTurk New New York New York City omicron Omicron variants problem protocol public health Qualtrics recent reported Research Research design response Selection selection bia Selection bias sensitivity sensitivity analysis skewed state subject Surveillance the disease Threats utility validation Validity variant [DOI] 10.2196/31306 PMC 바로가기 [Article Type] Article
From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease용도 변경에서 재설계까지: SARS-CoV-2 주요 프로테아제의 강력한 억제제에 대한 보세프레비르의 최적화Article Published on 2022-07-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3C-like protease activities activity addition alpha-ketoamides alphacoronavirus approach Betacoronavirus boceprevir complexes coronavirus COVID-19 coxsackievirus Coxsackievirus B3 crystal structure crystal structures Crystallography enterovirus enterovirus 3C protease exhibited Glutamine HCoV HCoV-NL63 hepatitis C hepatitis C virus inhibitor lactam M pro main protease moderate NL63 optimization potency potent protease Protease inhibitor Proteases replacing repurposing resulting SARS-CoV-2 starting structure-based design Structure-based drug design telaprevir telaprevir. the SARS-CoV-2 treatments for COVID-19 Validity virus X-ray X-ray crystallography [DOI] 10.3390/molecules27134292 PMC 바로가기 [Article Type] Article
Identification of potential pan-coronavirus therapies using a computational drug repurposing platform계산 약물 재검사 플랫폼을 사용한 잠재적 팬-코로나 바이러스 요법의 식별Article Published on 2022-07-012022-08-31 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome approach approved drug approved drugs artificial Artificial neural network causative agent clinical trials Computational drug coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 datasets disease disease outbreaks drug Drug mechanism Drug repurposing drugs effective facilitate Human identification Infectious disease infectious disease outbreak information mechanism mechanism of action methodology novel Outbreaks pandemic Pathways platform PPI PPI network predicted protein-protein interaction rapid response Replication respiratory SARS SARS-CoV seriously ill patients Severe acute respiratory syndrome therapeutic therapy Treatment Validity virus replication Zoonotic coronavirus [DOI] 10.1016/j.ymeth.2021.11.002 PMC 바로가기 [Article Type] Article
Emerging role of artificial intelligence in therapeutics for COVID-19: a systematic reviewReview Published on 2022-07-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] 3CLpro Algorithm antibody applied approach approved article artificial artificial intelligence clinical evaluation clinical trial coronavirus disease COVID-19 COVID-19 therapeutics database deep learning disease drug Drug discovery Drug repurposing effective English Evidence faster Host inhibiting interactions life-threatening methodology novel drug discovery pandemic researcher SARS-CoV-2 SARS-CoV2 searched systematic review targets Vaccine vaccine candidates Vaccine development Validity [DOI] 10.1080/07391102.2020.1855250 PMC 바로가기 [Article Type] Review
The validity of self-reported SARS-CoV-2 results among postpartum respondents산후 응답자 중 자가 보고한 SARS-CoV-2 결과의 타당성Article Published on 2022-07-012022-09-11 Journal: Paediatric and perinatal epidemiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] 95% CI Accuracy adjusted Administered age aRR AUC calculated Chain Reaction Characteristics Child development COVID-19 COVID-19 PCR test COVID-19 testing cross-sectional Diagnosis diagnostic Diagnostic accuracy examined gold gold standard Health Health Insurance Hispanic hospital individual majority mechanism medical record New York City obesity obstetrics PCR PCR test PCR testing PCR tests Poisson regression polymerase chain polymerase chain reaction population-based surveys predictor pregnant Rapid recall receipt Research risk risk ratio SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 PCR test SARS-CoV2 SARS-CoV2 PCR testing self-report sensitivity specificity subgroups tested Validity virus women [DOI] 10.1111/ppe.12874 PMC 바로가기 [Article Type] Article
Identification of potential COVID-19 treatment compounds which inhibit SARS Cov2 prototypic, Delta and Omicron variant infectionSARS Cov2 원형, Delta 및 Omicron 변이체 감염을 억제하는 잠재적인 COVID-19 치료 화합물의 식별Article Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료법, 치료제, [키워드] Anti-viral drug repurposing apilimod approach berbamine candidate drug cell death Cepharanthine clinical trial clinically Compound compounds COVID-19 COVID19 crizotinib Delta drug drug candidate effort FDA approval followed by Health identification Infection inhibit inhibited inhibitory effect less library multiple cell lines omicron Omicron variant Omicron variants Probability pseudovirus entry Recurrent replicated repurposing required robustness safety profile SARS CoV2 screened stratified Treatment Validity variant [DOI] 10.1016/j.virol.2022.05.004 PMC 바로가기 [Article Type] Article
The behavioral immune system in action: Psychological correlates of pathogen disgust sensitivity in healthcare professionals working in a COVID-19 hospitalResearch article Published on 2022-07-012022-10-05 Journal: Physiology & Behavior [Category] 유전자 메커니즘, [키워드] Behavioral immune system cognitive appraisals condition conducted Contact COVID-19 depressive symptom diagnosis of COVID-19 disgust ecological elicited emotional fear Germ aversion Health Healthcare professional healthcare worker Healthcare workers Hierarchical hospital Hypothesis immune system include Infection inhibit knowledge mechanism modulating offer pathogen promote Prophylaxis Psychological psychological reaction regression analysis reported sensitivity significant effect vaccination Validity [DOI] 10.1016/j.physbeh.2022.113821 [Article Type] Research article
Psychometric properties of the 21-item Depression, Anxiety, and Stress Scale (DASS-21) among Malaysians during COVID-19: a methodological study Research Published on 2022-06-292022-10-05 Journal: Humanities & Social Sciences Communications [Category] 치료법, [키워드] Anxiety average conducted correlated correlation Cronbach’s alpha cross-sectional DASS-21 Depression disease Evidence female participant indicate indicated internal consistency IRT item less Malaysia Malaysian Malaysians males mental health mental health conditions mental health issues methodological Model participant provide questionnaire reliability Research response resulting robust significantly higher standard error Stress Stress Scale Test theory total score utility Validity [DOI] 10.1057/s41599-022-01229-x [Article Type] Research
Determining the SARS-CoV-2 serological immunoassay test performance indices based on the test results frequency distribution검사 결과 빈도 분포를 기반으로 SARS-CoV-2 혈청 면역 분석 검사 성능 지수 결정Article Published on 2022-06-152022-09-12 Journal: Biochemia Medica [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% confidence interval Accuracy affected Antibody Response calculated coefficients components Concentration conducted Coronavirus disease 2019 COVID-19 COVID-19 testing cut-off value dataset determine Determining diagnostic diagnostic tests distribution Frequency IgG immunoassay Immunoglobulin individuals induce material non-linear regression predict Prevalence robust SARS-CoV-2 IgG SARS-COV-2 infection sensitivity Sensitivity and specificity serologic tests serological specificity subset the SARS-CoV-2 translate Validity [DOI] 10.11613/BM.2022.020705 PMC 바로가기 [Article Type] Article
Automatic detection of pneumonia in chest X-ray images using textural features조직학적 특징을 이용한 흉부 X선 영상에서 폐렴 자동 검출Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Algorithm artificial artificial intelligence Automatic Biomarker Biomarkers characterisation chest imaging chest X-ray Chest X-ray image Chest X-ray images composed COVID-19 COVID-19 pandemic Critical dataset detect Diagnosis diagnostic Diagnostic imaging feature forest Fractal Fractal dimension Histon Infection intelligence management Model pathology Pneumonia Radiomics Random forest Repository second sensitivity Superpixels support vector machine Symptom tested Triage Validity was used were used X-ray [DOI] 10.1016/j.compbiomed.2022.105466 PMC 바로가기 [Article Type] Article