Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spikeArticle Published on 2022-10-062022-11-16 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses Analysis antigenic variation complex COVID-19 Critical Deletion exacerbated fine-tune flexible functional Health Host Immunity mechanism membrane fusion Modification modulate Mutation N-terminal domain NTD omicron polymorphism receptor engagement remained responsible reveal Sarbecoviruses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant spike spike glycoprotein spike stability variant variants Variation Viral transmission virus entry [DOI] 10.15252/embr.202154322 PMC 바로가기
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antiviralsSARS-CoV-2 항바이러스제로서의 알데히드 기반 트리펩티딜 주요 프로테아제 억제제의 다각적 평가Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cell 293T cells active site aldehyde Amino acid amino acids Antiviral antiviral potency binding carbon cellular complexes conducted covalent inhibitors COVID-19 crystal structure cysteine cytotoxicity develop enzyme exhibited expressed flexible high potency in vitro inhibit inhibitor inhibitors interact low potency M pro main protease N-terminal pathogen Previous studies previous study Pro protease Protease inhibitor residue residues SARS-CoV-2 selected Structural variation structures tolerable Toxicity Treatment treatment of COVID-19 Tripeptides. unnatural Variation X-ray [DOI] 10.1016/j.ejmech.2022.114570 PMC 바로가기 [Article Type] Article
Phylodynamics of a regional SARS-CoV-2 rapid spreading event in Colorado in late 2020Article Published on 2022-10-042022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] Academy Aurora collected Community Course Divergence estimate Evolution force genomic initial Lineage Local outbreak Phylogenetic protocol rapid expansion replicate reported SARS-CoV-2 SARS-CoV-2 genome Sequencing spring Surveillance the SARS-CoV-2 the United State Transmission Transmission dynamics transmission pathway university variant Variation [DOI] 10.1371/journal.pone.0274050 PMC 바로가기
Estimating SARS-CoV-2 variant fitness and the impact of interventions in England using statistical and geo-spatial agent-based models통계 및 지리 공간 에이전트 기반 모델을 사용하여 SARS-CoV-2 변종 적합도 및 영국에서의 개입 영향 추정Article Published on 2022-10-032022-09-11 Journal: Philosophical transactions. Series A, Mathematical [Category] COVID19(2023년), SARS, 변종, [키워드] agent agent-based model Alpha B.1.1.7 B.1.177 death distribution dominant variant effective England Epidemics estimate Evolution example geo-spatial model Intervention Lineage lockdown lockdowns prevented relative reopening replaced REPLACED BY Reproduction number robustness SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 variant Spread statistical statistical model the epidemic Transmissibility vaccination Vaccinations variant variants Variation Viral variants virus variants [DOI] 10.1098/rsta.2021.0304 PMC 바로가기 [Article Type] Article
Prevalence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies in the Mozambican Population: A Cross-Sectional Serologic Study in 3 Cities, July-August 2020Article Published on 2022-10-032022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome adjusted African age anti-SARS-CoV-2 antibody city conducted coronavirus coronavirus 2 country COVID-19 cross-sectional exposure to General population group groups higher-risk occupational groups IgG IgM Immunoglobulin Maputo Mozambique pandemic Participants point-of-care Prevalence Public health intervention Randomly ranged Rapid test respiratory respond SARS-CoV-2 selected Sensitivity and specificity serologic Seroprevalence Serosurvey Sex tested Transmission Variation were measured [DOI] 10.1093/cid/ciac516 PMC 바로가기
Virtual screening and molecular dynamics simulation for identification of natural antiviral agents targeting SARS-CoV-2 NSP10Short communication Published on 2022-10-012022-10-05 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis Antiviral agents binding binding energy calculated Candidates complexes Compound COVID-19 docking enzymatic activity global pandemic inhibitor Interaction molecular dynamics Molecular dynamics simulation natural antiviral New nsp10 Protein RNA replication SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral selected stimulate suggested Vaccine Vaccine development Variation Virtual screening was performed ZINC database [DOI] 10.1016/j.bbrc.2022.08.029 [Article Type] Short communication
Porphyrinoids coated silica nanoparticles capacitive sensors for COVID-19 detection from the analysis of blood serum volatolomeResearch article Published on 2022-10-012022-10-05 Journal: Sensors and Actuators B: Chemical [Category] 치료기술, [키워드] Accuracy Affect Analysis Blood Capacitive gas sensors coated Compound COVID-19 COVID-19 sample diffusion Diseases Features identify Linear Discriminant Analysis Pathologies Porphyrinoids processed selective sensor serum Silica nanoparticles Variation Volatolomics [DOI] 10.1016/j.snb.2022.132329 [Article Type] Research article
Correlations between the urban built environmental factors and the spatial distribution at the community level in the reported COVID-19 samples: A case study of WuhanResearch article Published on 2022-10-012022-10-05 Journal: Cities [Category] 치료기술, [키워드] age applied association Built environmental factors changed Community Community level correlated COVID-19 COVID-19 spatial analysis Cycling dependent variables dimensions distribution environmental factor GDP Hierarchical Linear Regression hospital incidence rate indicated Intervention investigated limitation lockdown Model NPI positive Regression remained reported ridge Ridge regression School sociodemographic data sociodemographic factors spread of COVID-19 Transmission Variation with COVID-19 Wuhan [DOI] 10.1016/j.cities.2022.103932 [Article Type] Research article
Evidence in decision-making in the context of COVID-19 in Latin AmericaResearch article Published on 2022-10-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 진단, [키워드] Analysis characterized Community Corticosteroids country COVID-19 COVID-19 pandemic Decision-making diagnostic test eight Evidence facilitate finding funding Grounding hydroxychloroquine/chloroquine identify International Intervention Ivermectin Latin Latin America limitation majority methodology mitigate National NPI NPIs objective outcome rapid response reported risk of infection systematic review Travel treat understanding Variation was used [DOI] 10.1016/j.lana.2022.100322 [Article Type] Research article
Intrahost SARS-CoV-2 k-mer Identification Method (iSKIM) for Rapid Detection of Mutations of Concern Reveals Emergence of Global Mutation PatternsArticle Published on 2022-09-272022-11-15 Journal: Viruses [Category] SARS, 변종, 치료기술, [키워드] bioinformatics can be used computational genomics concern COVID-19 dataset detect detection emergence Frequency genome assembly Genome sequencing genomic genomic sequencing identification identify increases in Intrahost variation L452R Lineage lineages Mutation N501Y pattern Rapid raw data SARS-CoV-2 Sequencing spike Spread Surveillance the timing variant variants variants of concern Variation [DOI] 10.3390/v14102128 PMC 바로가기