Epidemiology, clinical spectrum, viral kinetics and impact of COVID ‐19 in the Asia‐Pacific regionArticle Published on 2021-03-092023-06-15 Journal: Respirology (Carlton, Vic.) [Category] MERS, SARS, [키워드] Clinical spectrum COVID‐19 Epidemiology Impact viral kinetics [DOI] 10.1111/resp.14026 PMC 바로가기
Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort프랑스 COVID 코호트의 입원 환자에서 SARS-CoV-2 바이러스 역학 및 사망률과의 연관성 모델링422 Published on 2021-02-232022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis analyzed association average build characterization chronic pulmonary disease Cohort collected coronavirus COVID death disease Effect effective Evolution French Gender hazard ratio High-risk patients Hospital admission hospitalized patient hospitalized patients identify independent infected cells information joint male mathematical mathematical model median median time modeling Mortality mortality rate Multivariate analysis nasopharyngeal viral occur older patients outcome Patient pharmacological intervention predict predicted prolonged viral shedding pulmonary disease reduce reduction respiratory risk factor Risk factors risk of death SARS-CoV-2 SARS-CoV-2 viral kinetics severe acute respiratory syndrome Coronavirus Significance Strategy survival symptom onset translate Treatment Treatment strategies Viral viral clearance viral dynamics viral kinetics Viral load Virological virus virus pathogenesis younger patient younger patients [DOI] 10.1073/pnas.2017962118 PMC 바로가기 [Article Type] 422
Mathematical analysis of a within-host model of SARS-CoV-2Research Published on 2021-02-172022-10-28 Journal: Advances in Difference Equations [Category] COVID-19, [키워드] 34A34 37N25 92B05 Analysis analyzed automatically basic reproduction number calculated COVID-19 patient epithelial cells feasible global stability Infection less math parameter SARS-CoV-2 stability Steady state viral kinetics [DOI] 10.1186/s13662-021-03276-1 PMC 바로가기 [Article Type] Research
Mild versus Severe Liver Injury in SARS-CoV-2 InfectionArticle Published on 2021-01-012023-06-19 Journal: Digestive diseases (Basel, Switzerland) [Category] MERS, [키워드] acute liver failure Coronavirus disease 2019 severe acute respiratory syndrome coronavirus-2 viral kinetics [DOI] 10.1159/000510758 PMC 바로가기
Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profilesSARS-CoV-2 및 ORF8이 결여된 382-nt 결실 분리주에 의한 인간 비강 상피 세포의 감염은 유사한 바이러스 동역학 및 숙주 전사 프로필을 나타냅니다Research Article Published on 2020-12-072022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] absence airway airway epithelial cells anti-viral gene up-regulation anti-viral signaling pathway anti-viral signaling pathways apical side basolateral secretion causative agent cell type cell types comparable conserved expression coronavirus disease Coronavirus disease 2019 CoV COVID-19 COVID-19 patients CXCL10 CXCL10 production cytokine cytokine production Cytokines differentiated NEC differentiated NECs distinct gene subset distinct gene subsets Duration of infection early response elevated elicited epithelial epithelial cell epithelial cells examined genomes global healthcare greater magnitude H3N2 healthy nasal-tissue highlight Host host gene expression Host immune response Host transcriptional response host-response hours post-infection hpi IL-6 Immune cell infiltration immune cells immune response impair in vitro In-vitro infancy infected cells infected NEC infected NECs Infection Infection of NEC Infection of NECs Infection with Δ382 infiltrating immune cell infiltrating immune cells Inflammatory response Influenza influenza strain late time-point late time-points less modulating Nasal Epithelial cells NECs Novel coronavirus novel coronavirus SARS-CoV-2 ORF8 other SARS-CoV-2 genes Pathogenesis patient sera patients plasticity post-infection time-point pro-inflammatory cytokine pro-inflammatory cytokines released reported reveal SARS-CoV-2 SARS-CoV-2 and Δ382 infection SARS-CoV-2 genes SARS-COV-2 infection Screening severe disease significantly similar replication kinetics similarities similarity Singapore stem cell stem cells subsequent cytokine production temporal up-regulation therapeutic node TNFα transcriptional transcriptional profile Transcriptome transcriptome analysis transcripts transcripts mapping understanding Viral viral clearance viral kinetics virus particle virus particles wild-type and Δ382 wild-type SARS-CoV-2 Δ382 Δ382 infected cell Δ382 infected cells Δ382 infection [DOI] 10.1371/journal.ppat.1009130 PMC 바로가기 [Article Type] Research Article
Molecular and serological characterization of SARS-CoV-2 infection among COVID-19 patientsCOVID-19 환자 중 SARS-CoV-2 감염의 분자 및 혈청학적 특성Article Published on 2020-12-012022-09-11 Journal: Virology [Category] MERS, SARS, 진단, 치료기술, [키워드] addition Admission anal swab analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody Response Blood clearance clinical information Cohort collected COVID-19 COVID-19 patient COVID-19 patients demographic detectable different time point different time points disease severity Diseases Evidence immunoassays infection control intestine investigated levels of antibodies levels of antibody management median Mild moderate moderate symptoms Most patients multiple tissue multiple tissues nasal Novel coronavirus occurred Patient Patient management patients pharyngeal positive qRT-PCR reached respiratory respiratory sample Respiratory samples Respiratory system RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA scientific evidence sensitivity serological severity significant difference Specific specimen swabs Symptoms the disease the patient variable Viral viral kinetics Viral load Viral protein Viral proteins Viral RNA were measured [DOI] 10.1016/j.virol.2020.09.008 PMC 바로가기 [Article Type] Article
Distinct Cytokine Profiles Correlate with Disease Severity and Outcome in Longitudinal Studies of Acute Hepatitis B Virus and Hepatitis D Virus Infection in ChimpanzeesResearch Article Published on 2020-11-172023-06-03 Journal: mBio [Category] B형 간염, Fulltext, [키워드] chimpanzees Cytokines Hepatitis Hepatitis B virus Hepatitis D Virus Pathogenesis precore HBV mutant viral kinetics wild-type HBV [DOI] 10.1128/mBio.02580-20 PMC 바로가기 [Article Type] Research Article
A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics실용적인 무작위 통제 시험에서 코로나바이러스 질병 2019 바이러스 동력학에 대한 하이드록시클로로퀸의 효능 부족 보고Article Published on 2020-10-202022-08-13 Journal: Nature Communications [Category] MERS, SARS, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission age Antiviral effect antiviral effects coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dose drug Efficacy eligible FIVE greater Human Hydroxychloroquine hydroxychloroquine therapy Identifier infected with SARS-CoV-2 lack moderately severe COVID-19 Older Oropharyngeal patients hospitalized positive patient Pragmatic Randomized Randomized controlled trial Randomized controlled trials respiratory SARS-CoV-2 SARS-CoV-2 oropharyngeal viral load Seven significantly standard care study inclusion Therapeutics therapy Treatment treatment of COVID-19 use of hydroxychloroquine Viral viral infection viral kinetics Viral load [DOI] 10.1038/s41467-020-19056-6 PMC 바로가기 [Article Type] Article
Impact of interleukin-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and antibody responses in patients with COVID-19: A prospective cohort studyArticle Published on 2020-10-012023-07-11 Journal: EBioMedicine [Category] SARS, [키워드] anti-cytokine therapy Antibody responses COVID-19 N-IgG S-IgG SARS-CoV-2 Tocilizumab viral kinetics [DOI] 10.1016/j.ebiom.2020.102999 PMC 바로가기
Plasma Hepatitis E Virus Kinetics in Solid Organ Transplant Patients Receiving RibavirinArticle Published on 2019-07-092023-05-23 Journal: Viruses [Category] E형 간염, Fulltext, [키워드] chronic infection hepatitis E virus ribavirin viral kinetics [DOI] 10.3390/v11070630 PMC 바로가기 [Article Type] Article