Viral proteins – Page 4 – Communicable Diseases Research

Anisotine and amarogentin as promising inhibitory candidates against SARS-CoV-2 proteins: a computational investigation

SARS-CoV-2 단백질에 대한 유망한 억제 후보로서의 아니소틴 및 아마로젠틴: 전산 조사

Article

Published on 2022-07-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제,

A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys

혈청학적 조사를 위한 BBV152(Covaxin) 전체 비리온 비활성화 SARS-CoV-2 백신의 수혜자의 감염 상태를 결정하기 위한 기계 학습 기반 접근 방식

Article

Published on 2022-07-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료법,

[키워드] age antibody antigens applied approach assessment assessments BBV152 Breakthrough infection can be used Clustering Consensus Covaxin COVID-19 COVID-19 pandemic Data science dataset Delta determine dose doses effective Effectiveness Ensemble methods generate help immune response inactivated Infection machine machine learning ML model neutralization Neutralization assay neutralize nucleocapsid antigens Population predicted premise Protein random recipient recipients SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine sequence sequences serological survey Sex spike Spike protein statistical subject subjects subset Support the vaccine type strain uninfected Vaccine vaccine response viral evolution Viral proteins virion wild type wild-type strain
[DOI] 10.1016/j.compbiomed.2022.105419 PMC 바로가기 [Article Type] Article

Identification of phytocompounds as newer antiviral drugs against COVID-19 through molecular docking and simulation based study

분자 도킹 및 시뮬레이션 기반 연구를 통한 COVID-19에 대한 새로운 항바이러스 약물로서의 식물 화합물 식별

Article

Published on 2022-07-012022-09-11
Journal: Journal of molecular graphics & modelling [Category] 변종, 치료제,

Immunoassay platform with surface-enhanced resonance Raman scattering for detecting trace levels of SARS-CoV-2 spike protein

SARS-CoV-2 스파이크 단백질의 미량 수준을 검출하기 위한 표면 강화 공명 라만 산란 기능이 있는 면역 분석 플랫폼

Article

Published on 2022-07-012022-09-11
Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술,

[키워드] aggregation antibody coated with comparable Concentration conjugation Conjugation in gold nanoparticles coronavirus disease COVID-19 COVID-19 patient COVID-19 patients disease early diagnosis genetic material gold Gold nanoparticle immunoassay lack limit of detection lowest Methylene Methylene blue multidimensional onset of symptoms plasma platform prevented Protein Resonant Raman molecules SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike protein detection scattering SERRS immunoassay Platform silica Silica shell functionalization. Spike protein Support the immunoassay Viral proteins
[DOI] 10.1016/j.talanta.2022.123381 PMC 바로가기 [Article Type] Article

SARS-CoV-2 variants preferentially emerge at intrinsically disordered protein sites helping immune evasion

Article

Published on 2022-07-012022-11-16
Journal: The Febs Journal [Category] COVID19(2023년), SARS, 변종,

Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro

비만 매개체는 SARS-CoV-2 감염 또는 시험관 내 1차 인간 폐 미세혈관 내피 세포 활성화에 영향을 미치지 않습니다

Article

Published on 2022-06-282022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술,

[키워드] activated Activation addition Adhesion Molecule adipokines adipose Adipose tissue Alter Cell cells clinical clinical observations COVID-19 Critically ill driving dysfunction E-selectin endothelial endothelial activation Endothelial cell endothelial cells Endothelial dysfunction evidenced exacerbate excess exposure to expression fat Human human lung ICAM-1 IL-6 Incubation individuals induce Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory response Inflammatory responses influence initiated lack Leptin lung Lungs mechanism mediator mounted obese obese COVID-19 patients obesity observation other organs outcome phenotype plasma pro-inflammatory produced virus required response SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection selectin severe disease shown susceptibility susceptibility to infection susceptible systemic level tested tissue VCAM-1 Viral protein Viral proteins virus visceral with COVID-19
[DOI] 10.3389/fimmu.2022.879033 PMC 바로가기 [Article Type] Article

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

SARS-CoV-2 변이체의 분자 특성, 면역 회피 및 영향

Review

Published on 2022-06-282022-09-11
Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제,

[키워드] accompanied antibody Anxiety benefit Characteristics clinical manifestation clinical manifestations concern COVID-19 COVID-19 pandemic Critical disease disease control drug and vaccine development Evolution exacerbated facilitate feature global effort global efforts global public health Health Organization heterogeneous highlight immune evasion Immunity Impact Infection molecular Mutation omicron pandemic public health Research SARS-CoV-2 variant SARS-CoV-2 variants Spread the SARS-CoV-2 Transmissibility Treatment Treatment effectiveness Vaccine development Vaccines variant variants viral dynamics Viral protein Viral proteins virus genome VoC World Health Organization
[DOI] 10.1038/s41392-022-01039-2 PMC 바로가기 [Article Type] Review

Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase

Research

Published on 2022-06-222022-10-05
Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료제,

Development of Monoclonal Antibodies to Detect for SARS-CoV-2 Proteins

SARS-CoV-2 단백질 검출을 위한 단클론항체 개발

Article

Published on 2022-05-302022-09-11
Journal: Journal of Molecular Biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small Molecules

SARS-CoV-2에 대한 새로 등장한 항바이러스 전략: 바이러스 단백질 구조 기능 해독에서 백신, 항체 및 소분자 개발까지

Review

Published on 2022-05-292022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antibody treatment Antiviral caused chemical compounds clustered regularly interspaced short palindromic repeats compounds contribute coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infection CRISPR development disease pathogenesis DNA dual exploration focus function functional Health Health crisis host cells inactive Infection inhibitors life cycle molecule monoclonal antibodies monoclonal antibody mRNA nonstructural proteins palindromic repeat Particles peptide-based Protein protein-based vaccine Protein-based vaccines Proteins provide research findings respiratory RNA vaccines SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus single-stranded Strategy structural proteins structure-function systematic review target targeted therapy targets the SARS-CoV-2 genome therapeutic option Therapeutic strategies therapy Treatment Vaccine Vaccine development Vaccines Viral viral life cycle Viral protein Viral proteins viral replication virus
[DOI] 10.3390/ijms23116083 PMC 바로가기 [Article Type] Review