Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors †Chemistry Published on 2020-09-012022-10-31 Journal: Chemical Science [Category] COVID-19, [키워드] acting clinically compounds conserved coronavirus cysteine cysteine protease domain drug resistance drug target Ebselen FIVE functional Helicase identify in viral inhibit inhibit SARS-CoV-2 nsp13 outbreak pandemic physical predicted protease Protein Proteins reduce Replication Safe SARS-CoV-2 Stage transcription factor Treatment Virus life cycle virus replication [DOI] 10.1039/d0sc02646h PMC 바로가기 [Article Type] Chemistry
Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposingArticle Published on 2020-07-142022-10-04 Journal: Nature Communications [Category] SARS, 신약개발, 치료제, [키워드] Algorithm Algorithms candidate Candidates caused coronavirus disease-2019 COVID-19 develop Drivers drug candidates Drug-target interactions Host hypothese Infectious disease information interactions molecular mechanism Network topology pathogenicity platform protein interactions Research resource SARS-CoV-2 SARS-COV-2 infection Scientific community Software Spread Systems biology Target identification the SARS-CoV-2 the SARS-CoV-2 virus time-consuming viral infection Virus life cycle [DOI] 10.1038/s41467-020-17189-2 PMC 바로가기 [Article Type] Article
Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesisReview Published on 2014-10-022022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] Affect Asthma Autoimmunity Cell cellular Central nervous system CNS CNS infection colds coronavirus demonstrated described disease distress Encephalitis etiology Factor Health hematogenous Host Host immune response Human human coronavirus humans individuals induce Infants infect infecting Infection Invasion involved Lower respiratory tract mice neurodegeneration neuroinvasion Neuroinvasive neurologic Neurological diseases Neurological disorders Neuron pathogen pathogenic processe Pathogens Pneumonia populations problems Regulation reported respiratory pathogen respiratory tract respiratory viral infection respiratory virus respond Spread suggested susceptible individual syndrome target cell triggering upper respiratory tract viral invasion viral replication virus Virus life cycle viruses [DOI] 10.1016/j.virusres.2014.09.011 PMC 바로가기 [Article Type] Review
Ezrin Interacts with the SARS Coronavirus Spike Protein and Restrains Infection at the Entry StageResearch Article Published on 2012-11-212022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Amino acid amino-acid Cell cellular Cluster complex coronavirus cysteine cytosol dependent on domain dominant negative early stage eight endodomain envelope fusion epithelial cells event ezrin Factor finding found glycoprotein host cell membrane in vitro Infection interact Interaction Lentiviral particle limit linker mechanism membrane fusion molecular mechanisms Particle performed pseudotyped regulate Regulation respiratory RNA S-pseudotyped particle SARS-CoV SARS-CoV S severe spike Stage susceptibility targeting VERO E6 cells viral envelope virus entry Virus life cycle yeast [DOI] 10.1371/journal.pone.0049566 PMC 바로가기 [Article Type] Research Article