Permissive omicron breakthrough infections in individuals with binding or neutralizing antibodies to ancestral SARS-CoV-2Article Published on 2022-09-292022-11-15 Journal: Vaccine [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome analyzed B.1.1.529 binding binding antibodies binding antibody breakthrough Breakthrough infection calibrated coronavirus correlated include individual Infection longitudinal cohort study marker Neutralizing activity Neutralizing antibodies neutralizing antibody occurred omicron Permissive Population ranged Recombinant spike protein S1 domain SARS-CoV-2 sequence sera Spike protein the spike protein vaccination rates variant WHO World Health Organization Wuhan-Hu-1 [DOI] 10.1016/j.vaccine.2022.08.058 PMC 바로가기
Report on influenza viruses received and tested by the Melbourne WHO Collaborating Centre for Reference and Research on Influenza during 2020-2021Article Published on 2022-09-262023-06-24 Journal: Communicable diseases intelligence (2018) [Category] 신종인플루엔자, [키워드] annual report GISRS Influenza Laboratory Surveillance Vaccines WHO [DOI] 10.33321/cdi.2022.46.63
The Receptor Binding Domain of SARS-CoV-2 Lambda Variant Has a Better Chance Than the Delta Variant in Evading BNT162b2 COVID-19 mRNA Vaccine-Induced Humoral ImmunityArticle Published on 2022-09-262022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding amino acid changes antibody bamlanivimab Better bind binding BNT162b2 BNT162b2 mRNA BNT162b2 vaccine chance COVID-19 Delta delta variant dropped evaluate the effect human Angiotensin-converting enzyme immunized individual L452R Lambda less Ligand mRNA Mutation mutations Protective protective effect RBD Receptor binding domain SARS-CoV-2 sera serum antibody serum antibody. T478K the RBD titer vaccinated individual vaccination Vaccine variant variants of concern variants of interest VoC WHO wild type World Health Organization [DOI] 10.3390/ijms231911325 PMC 바로가기
Safety, immunogenicity, and immune persistence of two inactivated COVID-19 vaccines replacement vaccination in China: An observational cohort studyArticle Published on 2022-09-162022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] administration Adverse reaction All participant anti-SARS-CoV-2 approved BBIBP-CorV can be used China Complete control group COVID-19 COVID-19 vaccine Cytopathic effect dose doses first dose geometric mean concentration geometric mean titer GMCs GMTs healthy immune persistence immunogenicity Immunoglobulin inactivated Inactivated vaccine Mild mitigate moderate NAb National not different not significantly different observation Observational cohort study Pragmatic regimens replacement Replacement vaccine Safety safety profile SARS-CoV-2 strain second dose sera severity Standard subject vaccination WHO [DOI] 10.1016/j.vaccine.2022.08.037 PMC 바로가기
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19Article Published on 2022-09-142022-11-15 Journal: Critical Care [Category] SARS, 치료기술, [키워드] 95% CI adjusted Antigen association AUROC baseline Clinical deterioration Clinical outcome clinical outcomes clinical status Coagulation collected Concentration correlated correlation correlations Course COVID-19 Cutoff death detectable Enrollment Hospital admission hospitalized COVID-19 hospitalized patient host response ICU admission IL-10 IMPROVE In-hospital increase in Inflammation IP-10 marker mechanical ventilation Multiple multiple logistic regression N-antigen Negative predictive value Pathogenesis Patient plasma plasma biomarker plasma concentration plasma sample Positive predictive value Primary outcome Prognosis prognostic progression prospective observational cohort RAGE risk stratification SARS-CoV-2 SARS-CoV-2 N-antigen SARS-CoV-2 nucleocapsid secondary outcome severe disease significantly Study participants subject tested tissue damage unlikely upper respiratory tract Viral antigen Viral RNA was used were assessed were measured WHO WHO ordinal scale with COVID-19 World Health Organization [DOI] 10.1186/s13054-022-04153-3 PMC 바로가기
Factors associated with neutralizing antibody levels induced by two inactivated COVID-19 vaccines for 12 months after primary series vaccinationArticle Published on 2022-09-092022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] age analyzed anti-SARS-CoV-2 antibody BBIBP-CorV blood sample booster dose booster doses change Chi-square China convalescent convalescent sera CoronaVac COVID-19 COVID-19 vaccine cross-sectional Cytopathic effect dose enrolled evaluated Factor Factors FIVE geometric mean concentration geometric mean titer GMC GMT immune immune persistence immunogenicity Immunoglobulin inactivated individual Influencing factors linear models Logistic regression NAb neutralizing antibody NIBSC nine number ranged real-world data recipient recipients sample sizes SARS-CoV-2 SARS-CoV-2 strain seropositive Seropositivity Sex Standard subject understanding vaccination Vaccine Vaccines Vero Cell were measured WHO Zhejiang [DOI] 10.3389/fimmu.2022.967051 PMC 바로가기
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, BrazilArticle Published on 2022-09-052022-11-16 Journal: BioMed Research International [Category] SARS, 변종, 유전자 메커니즘, [키워드] activated allele association Asymptomatic Brazil CARD8 center clinical clinical evolution Clinical management clinical manifestations contributing to COVID-19 COVID-19 severity death disease disease severity Factors Genetic Genetic variant Genotype group Haplotype Host host cells Inflammasome Inpatient investigated knowledge logistic regression models mechanism moderate NLRP3 NLRP3 inflammasome outcomes Patient performed polymorphism Polymorphisms profile protection Real-time PCR recruited Rio de Janeiro risk risk factor SARS-COV-2 infection SARS-CoV-2-infected individual scale severe symptom severity Significant single-nucleotide SNP SNPs Symptom the WHO two group two groups variants virus was determined WHO with mild disease [DOI] 10.1155/2022/9082455 PMC 바로가기
A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trialArticle Published on 2022-09-052022-10-05 Journal: Trials [Category] 임상, [키워드] 1:1 28-day mortality addition Admission Admissions Analysis Appendix 1 benefit Care changes in chronic chronic condition chronic disease chronic liver disease cirrhosis clinical Clinical improvement Clinicians Cohort conducted COVID-19 COVID-19 pandemic criteria disease evaluated exploratory subgroup analysis feasibility generalisability generate global healthcare Health Health Service health team healthcare Healthcare systems heart failure hospitalisation implementation implication include Interdisciplinary health team. interim analysis Intervention intervention arm liver Liver disease Melbourne, Australia Mortality mortality risk New outcome participant Patient performed Prevalence Primary outcome Quality of life randomisation randomised randomised controlled trial RCT readmission recruit recruited recruitment reduced reducing Registered Registration registry required resource rising robust Safe secondary severity small sample size social work Study protocol suggested Treatment Trial well WHO [DOI] 10.1186/s13063-022-06679-x PMC 바로가기 [Article Type] Article
A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cellsArticle Published on 2022-09-022022-11-15 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 비임상, 진단, [키워드] antibody Beta contagious cross-reactive Delta DNA vaccine domain evade functional Human human ACE2 receptor Immunity induce lethal disease lethal infection membrane mice neutralized neutralizing antibody New observation omicron pandemic priming PROTECT Protective SARS-CoV SARS-CoV vaccine SARS-CoV-2 Spike protein T cell T cells the SARS-CoV-2 Vaccine Vaccine development Vaccines variant variants virus WHO [DOI] 10.15252/emmm.202215821 PMC 바로가기
Prospective two-arm study of the testicular function in patients with COVID-19COVID-19 환자의 고환 기능에 대한 전향적 양군 연구Clinical Trial Published on 2022-09-012022-09-11 Journal: Andrology [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] Affect Agglutination reaction Analysis Autopsies Autopsy Cell Chest computed tomography collected Community Computed tomography Control COVID-19 COVID-19 pandemic COVID-19 patient damage died Direct discharge discharge home disorder Effect exhibited follicle-stimulating hormone Health Organization healthy control healthy controls Hospital stay human body increase in infiltration Inflammation International Laboratory lack Luteinizing Hormone majority male male fertility male hormone male reproductive system management MAR material moderate moderate to severe multiple organ multiple organs parameter participant Patient patients with COVID-19 patients with moderate positive postmortem examination Prospective Prospective Study reproductive reproductive system Research returned SARS-CoV-2 Semen Semen analysis severe disease significantly Sperm spermatogenesis Symptom testes testicle Testosterone the disease the healthy throat swab tissue Topic Trial Two-arm Viral pneumonia virus was performed WHO World Health Organization [DOI] 10.1111/andr.13159 PMC 바로가기 [Article Type] Clinical Trial