The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms
Review article
Published on
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료제,
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료제,
[키워드] ACE2angiotensin converting enzyme
AMP-activated protein kinase
AMPKAMP-activated protein kinase
angiotensin converting enzyme
antigen-presenting cells
antioxidant
APCantigen-presenting cells
c‐Jun N‐terminal kinase
clinical trial
Complication
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19coronavirus disease 2019
database
Direct
Diseases
distress
Effect
ERKextracellular signal-regulated kinase
Evidence
exhibited
extracellular signal-regulated kinase
Factor
HBVHepatitis B virus
HCVHepatitis C virus
Hepatitis B virus
hepatitis C virus
HIVhuman immunodeficiency virus
Human immunodeficiency virus
IFNγinterferon γ
ILInterleukin
immune system
Immune system dysfunction
Impact
indicate
Inflammation
Inflammatory response
interferon γ
interleukin
involved
JAKc‐Jun N‐terminal kinase
Like
MAPKmitogen-activated protein kinase
mechanism
MERS-CoVmiddle east respiratory syndrome coronavirus
Middle East respiratory syndrome Coronavirus
mitogen-activated protein kinase
neutrophil-lymphocyte-ratio
NF-κBnuclear factor kappa B
nitric oxide
NLRneutrophil-lymphocyte-ratio
NONitric Oxide
Nrf2nuclear factor erythroid 2–related factor 2
nuclear factor erythroid 2–related factor 2
nuclear factor kappa B
oxidative stress
pandemic
pathogenesis of COVID-19
protease
reactive oxygen species
reducing
Research
ROSreactive oxygen species
SARS-CoV 2severe acute respiratory syndrome coronavirus
SARS-CoV-2
SARSSevere Acute Respiratory Syndrome
Science
searched
Severe acute respiratory syndrome
severe acute respiratory syndrome Coronavirus
signal transducer and activation of transcription
silibinin
spike glycoprotein
STATsignal transducer and activation of transcription
T helper 1
target protein
TGF-βtransforming growth factor beta
Th1T helper 1
therapeutic benefits
therapeutic effect
therapy
TLR-4toll like receptor 4
toll like receptor 4
transforming growth factor beta
treating COVID-19
viral replication
Web of Science
WHOWorld Health Organization
World Health Organization
[DOI] 10.1016/j.biopha.2022.113593 [Article Type] Review article
[DOI] 10.1016/j.biopha.2022.113593 [Article Type] Review article