accelerated – Page 40 – Communicable Diseases Research

Essential gene deletions producing gigantic bacteria

거대 박테리아를 생성하는 필수 유전자 결실

Research Article

Published on 2019-06-102022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

Evaluation of an accelerated hydrogen peroxide disinfectant to inactivate porcine epidemic diarrhea virus in swine feces on aluminum surfaces under freezing conditions

Research Article

Published on 2017-12-012022-10-28
Journal: BMC veterinary research
[Category] Coronavirus,

[키워드] accelerated Accelerated hydrogen peroxide addition aluminum applied collected Concentration condition conditions Contact Contamination control group country determine Dilution Disinfection Efficacy epidemic diarrhea evaluated expected fecal glycol hydrogen peroxide inactivated infectious dose Infectivity inoculated negative and positive negative control nucleocapsid PEDV polymerase chain positive positive control Quantitative Randomly rectal swab representing Result reverse transcription RT-qPCR Seven Spread supplementary material Swab swine temperature Treatment treatment group virus was determined were used
[DOI] 10.1186/s12917-017-1300-4 PMC 바로가기 [Article Type] Research Article

Real-Time Sequence-Validated Loop-Mediated Isothermal Amplification Assays for Detection of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

Research Article

Published on 2015-04-092022-10-28
Journal: PLoS ONE
[Category] Coronavirus, MERS,

Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

Alpha1-항트립신 혈청 수준이 있는 SERPINA 유전자 클러스터의 변이체의 인과적 및 합성적 연관성

Research Article

Published on 2013-08-222022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] accelerated allele Alpha1-antitrypsin Analysis analysis antitrypsin association Author Blood Causal chromosomal locus chronic obstructive chronic obstructive pulmonary disease circulating city Cohort common variants complex Concentration contribute COPD deficiency defined Degradation determined driven by Effect emphysema enzyme examined example explained functional gene cluster General population Genetic genetic determinant genetic determinants Genetic polymorphism genetic polymorphisms Genetic variant Genome-wide association study genome-wide significance genotyped genotyping GWAS Health heart hidden independent individual inhibitor Level locus Lung function MAF MAFs Meta-analysis minor allele frequency nucleotide obstructive pulmonary disease participant phenotype PI polymorphism PROTECT Protein pulmonary disease pulmonary tissue reached reduce replicated Replication respiratory risk risk factor SERPINA1 SERPINA1 gene Serum level serum levels Single nucleotide polymorphism single nucleotide polymorphisms Smokers SNP SNPs subsequent suggested Support synthetic tissue transfer Variability variant variants while
[DOI] 10.1371/journal.pgen.1003585 PMC 바로가기 [Article Type] Research Article

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

Research Article

Published on 2011-12-082022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus,

[키워드] 40S accelerated accompany acute respiratory syndrome Antiviral Author bind binding block cells characterized circumvent classical cleavage cleavage sites coronavirus cricket paralysis viruses Degradation demonstrated different element elements events exhibited facilitate Fever found function Hepatitis Host host gene expression host genes host mRNA host protein in vitro induce infected cells Infection inhibitor leader sequence Modification mRNA mRNAs nucleotide nucleotide sequence Protein protein synthesis recognize reporter Resistant ribosome RNA RNA modification SARS Coronavirus SARS infection severe severe symptom subunit suppress the expression susceptible translation type I type I interferon unique viral mRNA Viral protein virus virus replication
[DOI] 10.1371/journal.ppat.1002433 PMC 바로가기 [Article Type] Research Article

Role of Exonic Variation in Chemokine Receptor Genes on AIDS: CCRL2 F167Y Association with Pneumocystis Pneumonia

AIDS에 대한 케모카인 수용체 유전자의 외음성 변이의 역할: 폐포자충과의 CCRL2 F167Y 연관성

Research Article

Published on 2011-10-272022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 95% CI accelerated addition Affect AIDS Amino acid analysis Analysis association associations Atypical Author CCR2 CCR3 CCR5 CCR8 CCRL2 Cell Chemokine receptor chromosome Cluster cohorts conditions CX3CR1 defined dendritic cell disease Disease progression DNA Effect exonic FIVE functional variant functional variants Gene Genes Genetic genetic association Genetic variation genotyped HIV-1 HIV-1 infection host cells Human immune regulation in addition to indicated Inflammation involved key factor lung majority natural history Non-synonymous outcome Pathogenesis Pneumonia progression role Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs surface protein survival survival analysis tested variant Variation
[DOI] 10.1371/journal.pgen.1002328 PMC 바로가기 [Article Type] Research Article

Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes

Somatic Genetics는 발달 및 질병 과정을 모델링하고 조사하기 위해 마우스를 강화합니다

Review

Published on 2011-07-212022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] accelerated be applied disease Disease progression Gene Genetic genetics genomic human biology human disease humanized in vivo mapped modeling mouse Mutagenesis Mutation pathway Pathways resource rodents Somatic therapeutic intervention to screen transposon
[DOI] 10.1371/journal.pgen.1002110 PMC 바로가기 [Article Type] Review

Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence

Research Article

Published on 2011-06-092022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] absence accelerated accessory gene acquisition Activation Analysis Antiviral antiviral response Apoptosis assay association Author benefit binding caspase catalytic caused Cell cellular RNA clinical disease compared conserved coronavirus CoV cultures Cytopathic effect Defense Degradation Deleterious demonstrated eIF2α ENCODE eukaryotic translation evade Evolution expression Genome growth Host host antiviral response host cell hydrophobic immune response indicated Infected infected cells Infection Innate inoculation Interaction led to mechanism modify modulation molecular mechanism motif mutant mutant virus Newborn observation parental pathology Pathways persistence Phosphorylation promoted Protein protein phosphatase 1 provided pull-down reducing required RNA degradation RNA viruses RNase selective sequence subunit suggested survival TGEV tissue translational transmissible gastroenteritis virus Viral RNA virulence virus virus virus infection
[DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article

Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses

Research Article

Published on 2009-09-232022-10-28
Journal: PLoS ONE
[Category] Coronavirus,

[키워드] accelerate accelerated antibody production Antigen appear Asymptomatic B cell CAGE cause CD4+ T cell clearance described destruction develop different disparate dose ENhance finding functional Host immune response immune response immune responses Immune-mediated Immunity independent Infection Inflammation influenza viruses inherent less limit lung lung damage Lymphoid tissue mechanisms morbidity nanoparticle novel virus pathogen Primary infection primary viral infection protection protective immune response Protein pulmonary viral recruitment Replication respiratory respiratory virus Safe SARS-coronavirus significant decrease significantly significantly increased specificity survival Treatment Vaccination strategies viral antigens viral clearance virus
[DOI] 10.1371/journal.pone.0007142 PMC 바로가기 [Article Type] Research Article