Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection The COVID A to Z Randomized Clinical Trial고용량 아연 및 아스코르빈산 보충제 대 일반 관리가 SARS-CoV-2 감염이 있는 보행 환자의 증상 기간 및 감소에 미치는 영향 COVID A to Z 무작위 임상 시험Randomized Controlled Trial Published on 2021-02-122022-08-13 Journal: JAMA Network Open [Category] MERS, 임상, [키워드] acid acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adverse effect adverse effects age ambulatory ambulatory patient ambulatory patients ascorbic acid benefit Care Chain Reaction clinical clinical trial Combination conditional power conducted coronavirus cough COVID cumulative deaths decrease diagnosed diagnosis of SARS-CoV-2 duration of symptom early treatment Effect end point enrolled Evidence fatigue Fever finding group groups health system High-dose hospitalizations Identifier Importance Infection Length mitigate multicenter no significant difference not affect objective Open-label open-label trial participant Patient Point polymerase chain polymerase chain reaction prescribed medications primary end point progression Randomized randomized clinical trial receive receiving reduce reduction in Registration Relevance required respiratory Result SARS-CoV-2 SARS-COV-2 infection secondary secondary outcome Secondary outcomes setting severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity Shortness of breath significant difference significantly Standard of care Symptom symptom severity score Symptoms Treatment treatment groups Trial Trial registration usual care women Zinc zinc gluconate [DOI] 10.1001/jamanetworkopen.2021.0369 PMC 바로가기 [Article Type] Randomized Controlled Trial
Early Impacts of the COVID-19 Pandemic on the United States Construction IndustryArticle Published on 2021-02-062022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] adopted adverse effect build construction construction delays construction productivity construction safety COVID-19 COVID-19 pandemic COVID-19 risk death effort ENhance Face masks Government Health hospitalizations Impact information Lessons learned management measure Mitigation strategies National Occupational safety offer offered pandemic protocols recommendations recruit reduce reduction in reported risk Safe safety risk secure significant delay social distancing temperature the United State widespread worker safety [DOI] 10.3390/ijerph18041559 PMC 바로가기 [Article Type] Article
Yindan Jiedu Granules, a Traditional Chinese Medicinal Formulation, as a Potential Treatment for Coronavirus Disease 2019Pharmacology Published on 2021-02-052022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 1:1 addition adverse effect Analysis analyzed baseline CD4 Characteristics Chinese coronavirus disease COVID-19 COVID-19 patient disease duration of fever Efficacy Factor Fever Formulation Granule herbal medicine independent individual lesion lesions Lopinavir-ritonavir Median recovery time Patient patients with COVID-19 Potential Predictive presenting Propensity score proportion PSM pulmonary exudative lesions recovered patient recovery proportion reveal significantly shorter standard care the Kaplan-Meier method the mean Toxicity Traditional Treatment treatment groups two groups was used Yindan Jiedu granules [DOI] 10.3389/fphar.2020.634266 PMC 바로가기 [Article Type] Pharmacology
Chloroquine and hydroxychloroquine for COVID-19: Perspectives on their failure in repurposingCOVID-19에 대한 클로로퀸과 하이드록시클로로퀸: 용도 변경 실패에 대한 전망Review Published on 2021-02-012022-09-11 Journal: Journal of clinical pharmacy and therapeutics [Category] Coronavirus, 신약개발, 치료제, [키워드] adverse effect antiviral activities Azithromycin balance Chloroquine choice clinical evidence Clinical studies clinical trial clinically COVID-19 COVID-19 infection COVID-19 patient dose Dose-response doses dosing regimens drug effective Efficacy effort Endpoint Evidence focus HCQ Hydroxychloroquine Infection interleukin interleukin-6 International National not effective Patient patients with COVID-19 Perspective phobia Prophylaxis proportion QT interval QTc interval question receiving recent reduction in regimen Result resulting risk therapeutic potential threshold Viral viral infections Viral load [DOI] 10.1111/jcpt.13267 PMC 바로가기 [Article Type] Review
Triple therapy with hydroxychloroquine, azithromycin, and ciclesonide for COVID-19 pneumoniaCOVID-19 폐렴에 대한 하이드록시클로로퀸, 아지트로마이신, 시클레소나이드의 삼중 요법Article Published on 2021-02-012022-09-11 Journal: Journal of microbiology, immunology, and infection [Category] SARS, 치료제, [키워드] adverse effect adverse effects Azithromycin Ciclesonide clinical condition COVID-19 COVID-19 pneumonia Effectiveness Hydroxychloroquine patients with COVID-19 Pneumonia reverse transcription reverse transcription-PCR SARS-CoV-2 the patient therapy [DOI] 10.1016/j.jmii.2020.09.003 PMC 바로가기 [Article Type] Article
Impact of the COVID-19 Pandemic on Oncologists: Results of an International Study코로나19 팬데믹이 종양 전문의에게 미치는 영향: 국제 연구 결과Multicenter Study Published on 2021-02-012022-09-12 Journal: JCO Global Oncology [Category] MERS, 진단, [키워드] 95% CI adverse effect African Brazil conducted contracting the virus COVID 19 COVID-19 COVID-19 pandemic COVID-19 vaccine cross-sectional Efficiency emotional evaluate Healthcare provider highest Impact Intention knowledge majority male Mental Middle East mitigate North Odds ratio oncologist Oncologists pandemic participant Participants participated Patient physician Prevent question questionnaire receive reported Research Resilience Result the disease Transmission Vaccine virus [DOI] 10.1200/GO.20.00542 PMC 바로가기 [Article Type] Multicenter Study
The effect of the COVID-19 pandemic on maternal health due to delay in seeking health care: Experience from a tertiary centerObservational Study Published on 2021-02-012022-10-05 Journal: International journal of gynaecology and obstetric [Category] 임상, [키워드] Admission Admissions adverse effect Affect Antenatal antenatal care Care collected Complication complications COVID-19 COVID-19 pandemic Delay Effect Emergency experience fetal Health Health care hygiene Infection intensive care lockdown Maternal Obstetric outcomes pandemic parturient positive Pregnancy pregnant women reduction resulting seeking single-center study social distancing symptomatic tested was performed women [DOI] 10.1002/ijgo.13457 PMC 바로가기 [Article Type] Observational Study
The Aging Bowel Dysfunction and Elderly Vulnerability towards COVID-19 InfectionReview Published on 2021-01-282022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] acute respiratory syndrome Adding adverse effect Affect affected aging chronic disease Community contribute coronavirus COVID-19 digestive disadvantage elderly function functions gastrointestinal tract dysfunction host receptor Hypothesis immune intestinal intestinal permeability intestinal tract morbidity morbidity and mortality mucosal New coronavirus nutraceutical nutraceuticals organs pandemic Prevent Protective respiratory tract SARS-CoV-2 senescent the SARS-CoV-2 virus vulnerability [DOI] 10.3390/life11020097 PMC 바로가기 [Article Type] Review
Social Distancing: Prevalence of Depressive, Anxiety, and Stress Symptoms Among Brazilian Students During the COVID-19 PandemicPublic Health Published on 2021-01-272022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, [키워드] 95% CI adverse effect Anxiety anxiety symptom association composed COVID-19 COVID-19 pandemic DASS-21 Depression depressive symptom exploratory study form mental health moderate-severe Occurrence pandemic physical Porto Prevalence problem protective factor provided psychological support questionnaire Research social distancing Sociodemographic Stress Stress Scale student students Symptom triggering variable was performed [DOI] 10.3389/fpubh.2020.589966 PMC 바로가기 [Article Type] Public Health
Mortality Benefit of Remdesivir in COVID-19: A Systematic Review and Meta-AnalysisMedicine Published on 2021-01-272022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% CI administration adverse effect adverse event Analysis antiviral activity antiviral drug benefit clinical trial Comprehensive conducted COVID-19 COVID-19 pandemic COVID-19 patients defined drug discontinuation effective Efficacy and safety full length indicated manuscript median Median recovery time Meta-analysis Mortality mortality rate outcome Patient patients treated performed Placebo Potential treatment Primary outcome public health emergency reduce remdesivir (GS-5734) review RNA virus SARS-CoV-2 secondary outcome significantly systematic review the mean therapy Treatment USA [DOI] 10.3389/fmed.2020.606429 PMC 바로가기 [Article Type] Medicine