connection
[용어속성] Term
Yeast Based Small Molecule Screen for Inhibitors of SARS-CoV
Research Article
[키워드] activities
activity
Alter
bypasse
Cell culture
cells
cellular
connection
conserved
Course
demonstrated
deubiquitinase
Diversity
expressed
functional
growth
human coronaviruses
induce
induction
Influenza virus
inhibit
inhibited
inhibiting the function
inhibitor
inhibitory compounds
investigated
likelihood
mammalian cells
mechanism
modify
molecule
Mortality
NIH
outbreak
Papain-like protease
phenotype
PLP
precursor
protease
Protease activity
Replication
reservoir
Respiratory Coronavirus
resulting
S. cerevisiae
SARS-CoV
Screen
severe
shown
small molecule
suppressor
toxic effect
virus replication
yeast
[DOI] 10.1371/journal.pone.0028479 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pone.0028479 PMC 바로가기 [Article Type] Research Article
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum
Research Article
[키워드] acute respiratory syndrome
alteration
Analysis
Antiviral
applied
arising
Author
biochemical
characterized
complex
connection
coronavirus
cytoplasm
cytosol
Defense
defined
dissect
double-stranded RNA
driven by
early stage
electron tomography
Endoplasmic reticulum
endoplasmic reticulum membrane
enzyme
ER membrane
host cell
host cell membrane
host cell membranes
host cells
human pathogen
implicated
in viral
induce
Infected
infected cell
interior
invagination
mechanism
mechanisms
membrane
membrane-bound
membranes
Microscopy
network
question
raise
replicate
Replication
replication complex
replicative protein
reported
Reticulum
reveal
RNA
RNA genome
RNA synthesis
RNA virus
RNA viruses
SARS-coronavirus
SARS-CoV
Structure
subunits
Support
thought
tomography
ultrastructure
unique
Vesicle
vesicles
viral replication
viral RNA synthesis
virus
Virus-host interactions
Web
[DOI] 10.1371/journal.pbio.0060226 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pbio.0060226 PMC 바로가기 [Article Type] Research Article
Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 Activation
Research Article
[키워드] Activation
ADP-ribosylation
Analysis
ARF
ARF1
association
Author
cells
cellular
cellular pathway
characteristic
complex
connection
coronavirus
Coronavirus replication
Critical
demonstrated
dominant-negative
downstream
Endoplasmic reticulum
Express
expression
Factors
GBF1
GTPase
GTPases
guanine
Host
Human
induce
infected cell
Infection
inhibited
inhibiting
interfere
involved
knockdown
MDCK cells
membrane
MHV
Microscopy
mouse
mouse hepatitis
mutant
nucleotide
observation
provide
Quantitative
reduced
Replication
replication complex
required
RNA
RNA virus
secretory pathway
significantly
siRNA
siRNAs
structures
target
vesicles
viruses
[DOI] 10.1371/journal.ppat.1000088 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1000088 PMC 바로가기 [Article Type] Research Article
SARS-Coronavirus Replication/Transcription Complexes Are Membrane-Protected and Need a Host Factor for Activity In Vitro
Research Article
[키워드] activity
acute respiratory syndrome
addition
Author
cause
centrifugation
characteristic
complex
complexes
connection
Critical
cytoplasm
cytoplasmic
Degradation
dependent on
develop
digestion
dissect
eight
enzyme
Enzymes
Factor
fraction
functional
genomic RNA
Host
host cell membranes
host cells
in vitro
in vitro activity
Infected
infected cell
life-threatening
membrane
membrane structure
membrane structures
membranes
non-structural protein
NSP
Nsps
polyproteins
precursor
produced
protease
PROTECT
protein synthesis
released
remained
replicate
Replication
required
RNA
RNA synthesis
robust
RTC
SARS-coronavirus
SARS-CoV
SARS-CoV-infected cells
Structure
subgenomic mRNA
subgenomic mRNA synthesis
subunit
susceptible
Transcription
Treatment
viral genome replication
Viral RNA
viral RNA synthesis
virus-induced membrane structure
virus-induced membrane structures
[DOI] 10.1371/journal.ppat.1000054 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1000054 PMC 바로가기 [Article Type] Research Article