Innate immune responses to influenza A H5N1: friend or foe?Article Published on 2016-05-192023-06-14 Journal: Trends in immunology [Category] Fulltext, 신종인플루엔자, [키워드] cytokine H5N1 Influenza innate immune response Macrophage pandemic [DOI] 10.1016/j.it.2009.09.004 PMC 바로가기 [Article Type] Article
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and HistonesCaenorhabditis elegans 단백질 FIC-1은 Heat-Shock 70 계열 단백질, 번역 연장 인자 및 히스톤을 공유적으로 수정하는 AMPylase입니다Research Article Published on 2016-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach ATP bacterial pathogen biochemical Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans connection consequence conserved core histone domain elegan elegans elongation elongation factors Endoplasmic reticulum Factor Factors family family members functional Heat shock heat shock protein heat-shock protein histone identify in vitro in vivo innate immune response Innate immunity modify novel nuclear ortholog P . aeruginosa pathogen phenotype post-translational modification Previous studies previous study Protein Proteins Pseudomonas aeruginosa sequence identity substrate susceptibility target protein target proteins three-dimensional structure translation unfolded protein response UPR [DOI] 10.1371/journal.pgen.1006023 PMC 바로가기 [Article Type] Research Article
The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assemblyArticle Published on 2016-01-012023-06-16 Journal: The Febs Journal [Category] B형 간염, [키워드] antiviral response cGAS-STING signaling pathway Hepatitis B virus innate immune response viral assembly [DOI] 10.1111/febs.13563
A Transgenic Mouse Model of Poliomyelitis폴리오마이엘리티스의 트랜스제닉 마우스 모델book-chapter Published on 2016-01-012024-08-01 Journal: Methods in molecular biology (Clifton, N.J.) [Category] 폴리오, [키워드] innate immune response Intracerebral inoculation knockout mouse motor neuron neurovirulence paralysis Poliovirus receptor Rodent model tissue tropism Viral antigen [DOI] 10.1007/978-1-4939-3292-4_7 [Article Type] book-chapter
The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birdsResearch Article Published on 2015-10-092022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Affect analysed Bacterial infection biological pathway can be used candidate gene cause chicken contagious coronavirus disease Disease resistance Effect evaluated examined expression functional Gene Expression gene expression differences Genetic Genome help Host host response IBV IBV infection identify immune response Infection Infectious Bronchitis Virus innate immune response involved lesion Microarray Mortality occur Post-infection Potential reproductive resistance gene Respiratory disease responsible Result selective subsequent supplementary material susceptible target the disease tissue tracheal vaccination virus were used [DOI] 10.1186/s12917-015-0575-6 PMC 바로가기 [Article Type] Research Article
Cytokine and chemokine profile of the innate and adaptive immune response of schistosoma haematobium and plasmodium falciparum single and co-infected school-aged children from an endemic area of Lambaréné, Gabon가봉 람바레네의 풍토병 지역에서 단일 및 공동 감염된 학령기 아동의 Schistosoma haematobium 및 Plasmodium falciparum의 선천적 및 적응 면역 반응의 사이토카인 및 케모카인 프로필Research Published on 2015-02-252024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Adaptive immune response Co-infection Epidemiology innate immune response Lambaréné malaria principal component analysis Schistosomiasis School-aged children [DOI] 10.1186/s12936-015-0608-4 PMC 바로가기 [Article Type] Research
Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infectionsArticle Published on 2015-02-152023-06-02 Journal: Veterinary Immunology and Immunopathology [Category] 조류인플루엔자, [키워드] DF-1 H9N2 IFN-β innate immune response Muscovy duck RIG-I [DOI] 10.1016/j.vetimm.2014.12.009
The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activityResearch Published on 2014-12-072022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Activation activity blocked chromatin immunoprecipitation complex interaction contribute coronavirus dependent on DNA binding downstream DUB EMSA engage experiment expressing Factors Host identify IFN Infection inhibit inhibited inhibiting inhibition activity innate immune innate immune response Innate immunity interferon IRF3 mechanism Mutagenesis mutant nuclear outcome Pathogenesis pathway Phosphorylation Plasmid PLPro potential mechanism protease Protein regulate regulated Result SARS Coronavirus SARS-CoV Severe acute respiratory syndrome shift shown Signaling Type I IFN type I interferon viral infection [DOI] 10.1186/s12985-014-0209-9 PMC 바로가기 [Article Type] Research
Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expressionArticle Published on 2014-11-262022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] accumulating acute respiratory syndrome antiviral responses biological function common conserved coronavirus CoV CoV infection CoVs determine downregulation Evidence Factor function functional highly pathogenic Host host gene expression human coronavirus inhibit innate immune response knowledge mammalian Middle East modulate mRNA cleavage nonstructural protein 1 novel nsp1 Pathogenesis Protein provide Regulation RNA viruses SARS SARS Coronavirus syndrome translation inhibition unique Vaccine development viral gene expression Viral protein virulence [DOI] 10.1016/j.virusres.2014.11.019 PMC 바로가기 [Article Type] Article
Coronavirus-induced ER stress response and its involvement in regulation of coronavirus–host interactionsArticle Published on 2014-10-072022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activated activating Activation anti-apoptotic Apoptosis Apoptotic cell death ATF6 autophagy cause Cell coronavirus Coronavirus infection coronavirus protein cross-talk Degradation disturbance Endoplasmic reticulum ER stress eukaryotic cells Evidence facilitate homeostasis induce infected cells innate immune response Innate immunity Interaction involved knowledge Modification modulate occur pathological conditions pathway Pathways physiological pro-apoptotic pro-inflammatory cytokines pro-inflammatory response Protein protein synthesis Regulation Replication shown signaling pathway signaling pathways transcriptional translation transmembrane unfolded protein response UPR [DOI] 10.1016/j.virusres.2014.09.016 PMC 바로가기 [Article Type] Article