interferon – Page 40 – Communicable Diseases Research

Interferon-α2 Auto-antibodies in Convalescent Plasma Therapy for COVID-19

COVID-19에 대한 회복기 혈장 요법의 인터페론-α2 자가항체

Original Article

Published on 2021-11-122022-09-10
Journal: Journal of Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제,

Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19

여성이 더 잘하는 이유: 코로나19에서 X 염색체 TLR7 유전자 용량 효과

Immunology

Published on 2021-11-112022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법,

[키워드] age biallelic caused concerning contribute COVID-19 COVID-19 pandemic COVID-19 treatment dendritic cells Effect expression Factor female gene-dose effect Hypothesis ICU IFN IFN pathway IFN response Immune cell immune cells Immunopathogenesis inactivation Infection interferon investigated Male sex modulation Mortality Pattern recognition pattern recognition receptor Pattern recognition receptors plasmacytoid dendritic cell plasmacytoid dendritic cells Protective responsible SARS-CoV-2 severe COVID-19 severity Sex difference sex differences sex hormone Sex hormones ssRNA TLR TLR7 TLR7 gene Toll-like receptor Treatment type 1 interferon Viral viral infections X chromosome X chromosome inactivation escape
[DOI] 10.3389/fimmu.2021.756262 PMC 바로가기 [Article Type] Immunology

Age-Related Expression of IFN-λ1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected Individuals

Immunology

Published on 2021-11-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] age Ageing analyzed Anti-viral Antiviral Asymptomatic Comorbidities COVID - 19 defensin effective expression expression pattern form forms Gender groups heterogeneous Host identify IFITM1 IFITM3 IFN - interferon IFN-I IFN-α IFN-β IFN-λ1 individual induce infected with SARS-CoV-2 Infection innate immune innate immune response Innate immunity interferon interferon-stimulated gene intrinsic LL-37 Local modulation mRNA expression mRNA level mucosa mucosal mucosal immunity nasopharyngeal nasopharyngeal mucosa Nasopharyngeal swab occur pediatric peptide Primary infection protective role Protein reached SARS – CoV – 2 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection selected selective subject subjects susceptibility symptomatic Symptoms the SARS-CoV-2 triggered type I type III upregulated upregulation virus β-defensin
[DOI] 10.3389/fimmu.2021.750279 PMC 바로가기 [Article Type] Immunology

High Frequencies of Functional Virus-Specific CD4 + T Cells in SARS-CoV-2 Subjects With Olfactory and Taste Disorders

Immunology

Published on 2021-11-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] acute phase Anosmia CD4 CD4 and CD8 CD8 clearance clinically control group COVID - 19 COVID-19 develop disorder evaluated extension Frequency functional granzyme B help IFN gamma IFNγ immune response Increased individual individuals interferon Lower respiratory tract Mild Mild symptom nasopharyngeal Outpatient Patient patients with SARS-CoV-2 peptide megapool presenting symptom robust SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 positive patient SARS-CoV-2 protein SARS-CoV-2 RNA secretion serology serum severe COVID-19 severe disease Severe infection spike spike-specific IgG Swab Symptom symptomatic T cell T cell response T-cell activation T-cell Response Taste the disease thought virus specific T cells Virus-specific IgG
[DOI] 10.3389/fimmu.2021.748881 PMC 바로가기 [Article Type] Immunology

An Immunomodulatory Transcriptional Signature Associated With Persistent Listeria Infection in Hepatocytes

Original Research

Published on 2021-11-102023-08-30
Journal: Frontiers in Cellular and Infection Microbiology [Category] E형 간염,

[키워드] acute phase response cholesterol Innate immunity interferon Listeria monocytogenes liver persistence transcriptomics
[DOI] 10.3389/fcimb.2021.761945 PMC 바로가기 [Article Type] Original Research

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

초기 IFN-α 시그니처와 지속적인 기능 장애는 심각한 COVID-19에서 NK 세포의 구별되는 특징입니다

Multicenter Study

Published on 2021-11-092022-09-11
Journal: Immunity [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anti-SARS-CoV-2 Antiviral Cell Clinical course Cohort coronavirus coronavirus disease COVD-19 COVID-19 disease Diseases dysfunction elevated exhibited expression feature fibrosis functional IFN IFN-stimulated gene IFN-stimulated genes IFN-α Immunopathogenesis independent indicate induced genes innate immune system interferon involved ISGs longitudinal Longitudinal analyses lung Lung disease Lung fibrosis moderate Moderate COVID-19 natural killer Necrosis NK cell NK cells outcome Patient performed plasma Plasma levels proteomics respiratory scRNA-seq severe severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling single-cell Single-cell transcriptomics symptom onset TNF TNF response TNF responses transcriptomics Tumor tumor necrosis tumor necrosis factor type 1 IFN. upregulation
[DOI] 10.1016/j.immuni.2021.09.002 PMC 바로가기 [Article Type] Multicenter Study

Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis

다발성 경화증에서 COVID-19 중증도와 질병 수정 요법의 연관성

41

Published on 2021-11-092022-09-12
Journal: Neurology [Category] MERS, SARS, 진단,

[키워드] 95% CI 95% confidence interval Acetate adjusted adjusted odds ratio Admission admitted to ICU age Alemtuzumab analyzed artificial ventilation association Characteristics Cladribine Cohort coronavirus disease Coronavirus disease 2019 country covariate covariates COVID-19 COVID-19 cases COVID-19 severity cross-sectional design death demographic demonstrated died dimethyl fumarate disability EDSS EDSS score examined fumarate Glatiramer Glatiramer acetate higher risk Hospitalization Hospitalized ICU ICU admission immunosuppressive include increased risk indication intensive care intensive care unit interferon internal and external International Logistic regression Multiple multiple sclerosis Natalizumab objective Ocrelizumab Older age outcome outcomes Patient phenotype reflected required restriction Result risk factor rituximab scale sclerosis severe coronavirus disease severe COVID-19 severity Sex Siponimod status Stratification therapy Ventilation were assessed with COVID-19
[DOI] 10.1212/WNL.0000000000012753 PMC 바로가기 [Article Type] 41

Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine

SARS-COV-2 불활성 백신에 의해 유도 된 항체 및 T 세포에 의한 관심의 변이체 인식

Clinical Trial

Published on 2021-11-092022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 임상, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Alpha antibodies antibody approved B.1.1.7 B.1.351 Beta Beta variant binding cellular response Cellular responses Chilean circulating variant clinical trial concern CoronaVac coronavirus D614G death rate Delta delta variant described detect dose elicited ELISPOT enrolled evaluate evaluated Gamma genetic difference genetic differences geometric mean Geometric means house human ACE2 receptor immune response immunization immunization schedule immunization schedules immunized immunogenic in-house ELISA inactivated induced Infection interferon interferon-γ-secreting T cell interferon-γ-secreting T cells Lineage microneutralization neutralization neutralize Neutralizing antibodies neutralizing antibody neutralizing capacity P.1 pandemic PBMC PBMCs Phase 3 phase 3 clinical trial promote Protective RBD Receptor binding domain Recognition reduced respiratory responsible Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants secreted secretion Seropositivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significant differences spike stimulate subject T cell immunity T cells tested the RBD the SARS-CoV-2 the vaccine titers Vaccine variant variants variants of concern virus Volunteer volunteers were used Wuhan Wuhan, China
[DOI] 10.3389/fimmu.2021.747830 PMC 바로가기 [Article Type] Clinical Trial

The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection

Review

Published on 2021-11-082022-11-01
Journal: Clinical and Molecular Allergy : CMA [Category] COVID-19,

Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications

COVID-19에서 혈소판 염증 및 내피 손상의 병원성 근거: 현재 연구 결과 및 치료적 시사점

Review

Published on 2021-11-082022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] activities acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Atypical B cell responses Basis cardiovascular risk factors cause caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current dry cough dysregulated dysregulated immune responses Endothelial dysfunction endothelial injury exacerbated Fever finding global pandemic high mortality highlight immune evasion immune responses Inflammation interferon interferon signaling interstitial pneumonia knowledge leads mechanisms morbidity Most patients multiple organ failure Organ failure Pathogenesis pathogenesis of COVID-19 pathogenic patients platelet activation platelet hyperactivation public health respiratory respiratory distress resulting SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases suppression symptoms of COVID-19 syndrome T cell therapeutic strategy Therapeutics Thromboembolism Thromboinflammation thrombosis
[DOI] 10.3390/ijms222112081 PMC 바로가기 [Article Type] Review