Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium1차 인간 기도 상피에서 SARS-CoV-2 향성의 단일 세포 분해능, 항바이러스 반응 및 요법에 대한 감수성Research Article Published on 2021-01-282022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, 치료제, [키워드] airway epithelial cells airway epithelium Antiviral antiviral immunity antiviral responses antiviral therapies antiviral therapy array blocked Cell cell population cell type cell types cellular ciliated cell ciliated cells Ciliated epithelial cells contribute COVID-19 pathogenesis dominant element elements epithelial cell epithelial cell type epithelial cell types epithelial cells expressed Factor flow cytometry gene signatures heterogeneity heterogenous host protease host protease TMPRSS2 Human airway epithelium hyperinflammatory responses IL-6 induction infect infected cell infected cells Infection inhibited initial interferon interferon response ISG ISGs mediator outcome Pathogenesis predominant primary human airway Remdesivir required respiratory respiratory tract RNA-sequencing SARS-CoV-2 SARS-COV-2 infection secretory cell secretory cells Single Cell susceptibility susceptible therapy These cells TMPRSS2 Treatment Treatment response variety Viral viral replication viral tropism [DOI] 10.1371/journal.ppat.1009292 PMC 바로가기 [Article Type] Research Article
Demand Analysis of a Psychiatric Emergency Room and an Adolescent Acute Inpatient Unit in the Context of the COVID-19 Pandemic in Madrid, SpainPsychiatry Published on 2021-01-272022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] acute inpatient unit adaptive Adolescent average Care changes in Chi-square conducted Contagion Context COVID-19 decrease Demand described dropped Emergency emergency room explained Fisher exact test hospital Hospital stay Hospitalized identify initial Inpatient Mann-Whitney test Measures mental health pandemic Patient performed predominant Psychiatric psychiatry quantitative variables retrospective room Shock Spain SPSS statistical significance thought Treatment unit university variable variables WHO World Health Organization [DOI] 10.3389/fpsyt.2020.557508 PMC 바로가기 [Article Type] Psychiatry
SARS-CoV-2 infection in an infant with non-respiratory manifestations: a case reportCase Report Published on 2021-01-252022-10-31 Journal: Egyptian Pediatric Association Gazette [Category] COVID-19, [키워드] absence Adults Anemia Case report children Computed tomography cough COVID-19 COVID-19, Pediatrics, Pancytopenia, Case report disease Fever incidence Infant initial Laboratory less manifestation non-specific pallor Pancytopenia polymerase chain positive predominant purpura Region reported respiratory manifestations respiratory symptom reverse transcription RT-PCR SARS-CoV-2 SARS-COV-2 infection Symptoms the disease with COVID-19 [DOI] 10.1186/s43054-020-00047-7 PMC 바로가기 [Article Type] Case Report
Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: incidence, risk factors, and pathogenesis – a systematic review and meta-analysis2019년 코로나바이러스 질환 환자의 출혈성 및 허혈성 뇌졸중: 발병률, 위험 요인 및 발병 기전 - 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-01-192022-09-12 Journal: F1000Research [Category] 진단, [키워드] 95% CI article calculated Characteristics concerning coronavirus disease COVID-19 COVID-19 patient COVID-19 patients database determine eligible haemorrhagic stroke Hemorrhagic Hemorrhagic Stroke Hospital admission incidence individual individuals with COVID-19 Ischemic Stroke mechanism Meta-analysis mortality rate Neurological symptom Occurrence Pathogenesis Patient patients with COVID-19 predominant Prevalence reported respiratory symptom Result retrieved Risk factors SARS-CoV-2 searched stroke Symptom systematic review the disease was used Web of Science [DOI] 10.12688/f1000research.42308.1 PMC 바로가기 [Article Type] Meta-Analysis
Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect인간 게놈 다양성 데이터는 L564P가 우세한 TPC2 변이체이며 M484L 기능 획득 효과와 관련된 금발 머리의 전제 조건임을 보여줍니다Research Article Published on 2021-01-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addition affected Analysis analyzed association Bacterial infections bacterial toxin bacterial toxins Cancer cancer cell Cancer cells cation channel changes in characterized cholera toxin cholesterol data set database Degradation described diabete diabetes disease Diseases distribution drug target Ebola Ebola virus Effect example functional gain-of-function Genome Genome-wide association studies Genome-wide association study geographical distribution glucagon hair color Human human disease Human genome human population human populations implicated Infectious disease Infectious diseases investigated isoform likelihood melanin Meta-analysis metabolic disease mice nucleotide obesity overlapping Parkinson’s disease pathophysiological pharmacological physiological pigmentation defect pigmentation defects polymorphism Polymorphisms populations predominant Protein provide reduced resulting secretion Single nucleotide polymorphism single nucleotide polymorphisms systematic analysis traits Treatment variant Variation variations virus viruses was performed were assessed [DOI] 10.1371/journal.pgen.1009236 PMC 바로가기 [Article Type] Research Article
Acute Stroke Care in the With-COVID-19 Era: Experience at a Comprehensive Stroke Center in JapanNeurology Published on 2021-01-182022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] acute ischemic stroke Admission Admissions affected baseline Brain Care center changed Comprehensive Computed tomography consecutive patient coronavirus disease COVID-19 COVID-19 pandemic discharge Emergency experience female Frequency healthcare hospital In-hospital intravenous Japan magnetic resonance imaging Mechanical thrombectomy median median age Metrics Neuroimaging no significant difference outbreak outcome pandemic Patient predominant proportion reperfusion scale state stroke therapy Thrombolysis [DOI] 10.3389/fneur.2020.611504 PMC 바로가기 [Article Type] Neurology
Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a태국에서 SARS-CoV-2의 게놈 감시는 혼합된 수입 개체군, 지역 혈통 확장 및 잘린 ORF7a가 있는 바이러스를 보여줍니다Article Published on 2021-01-152022-09-11 Journal: Virus research [Category] Coronavirus, SARS, 변종, 유전자 메커니즘, [키워드] coronavirus disease Coronavirus disease 2019 country COVID-19 diagnostic Genomic surveillance global public health Host Lineage Local ORF7a populations predominant reveal SARS-CoV-2 Thailand the SARS-CoV-2 truncated ORF7a virus [DOI] 10.1016/j.virusres.2020.198233 PMC 바로가기 [Article Type] Article
Tissue Distribution of ACE2 Protein in Syrian Golden Hamster ( Mesocricetus auratus ) and Its Possible Implications in SARS-CoV-2 Related StudiesPharmacology Published on 2021-01-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 ACE2 expression age Analysis Angiotensin converting enzyme-2 angiotensin-converting enzyme 2 animal model antibody clinically conducted COVID 19 demonstrated detectable disease epithelial cells epithelium evaluate evaluated Evidence expresse expression functional group hamster hamster (Mesocricetus auratus) human tissue immunofluorescence analysis immunohistochemistry intestine kidney knowledge lack liver lung Mesocricetus mRNA level organ pathology predominant Protein provided proximal reagent receptor RT-qPCR SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection Sex small intestine the antibody tissue tissue-specific expression tongue tracheal [DOI] 10.3389/fphar.2020.579330 PMC 바로가기 [Article Type] Pharmacology
Hand Hygiene Knowledge, Perception, and Practices among Domestic Visitors to the Prophet’s Mosque in Al Madinah City Amid the COVID-19 Pandemic: A Cross-Sectional StudyArticle Published on 2021-01-142022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, [키워드] alcohol city collected conducted COVID-19 cross-sectional survey demographic data demonstrated female had no hand hand hygiene hands with soap hygiene Immunity knowledge knowledge score Lower median moderate Mosque MOST participant Perception Practice predominant questionnaire Saudi Arabia scored spread of COVID-19 Standard deviation thought Visitor visitors to the Prophet’s Mosque washing waste disposal [DOI] 10.3390/ijerph18020673 PMC 바로가기 [Article Type] Article
Chest CT features associated with the clinical characteristics of patients with COVID-19 pneumonia코로나19 폐렴 환자의 임상적 특징과 관련된 흉부 CT 특징Research Article Published on 2021-01-102022-09-01 Journal: Annals of Medicine [Category] 진단, [키워드] abnormality age bilateral lung Chest CT Clinical characteristics clinical manifestation Computed tomography consolidation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients diagnosing enrolled feature Follow-up GGO Ground-glass opacities ground-glass opacity help initial lesion less lung men MONITOR Next-generation sequencing nodule nodules objective outcome Patient patients with COVID-19 Pneumonia predict predominant Prognosis Result RT-PCR SARS-CoV-2 imaging features Severe case severe cases severity significantly lower Stage TSS with COVID-19 women [DOI] 10.1080/07853890.2020.1851044 PMC 바로가기 [Article Type] Research Article