Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice
Research Article
Published on
Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 치료제,
Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 치료제,
[키워드] acute respiratory syndrome
administration
Antiviral
antiviral activity
antivirals
approval
Breakthrough infection
conserved
coronavirus
coronavirus disease
CoV
COVID-19
Culture
description
develop
dose-dependent
drug
effective
EUA
exhibited
GS-441524
in vitro
in vivo
increasingly
infected with SARS-CoV-2
Infection
lung
lung cell
lung cell line
MERS-CoV
mice
Middle East
molnupiravir
monoclonal antibodies
neutralization
outpatients
pandemic
parent nucleoside
parental
pharmacokinetic
Protective
Pulmonary function
reduced
Remdesivir
respiratory
RNA-dependent RNA polymerase
Safe
SARS-CoV-2
SARS-CoV-2 pathogenesis
SARS-CoV-2 variant
Support
target
therapeutic
therapeutic efficacy
translated
Treatment
vaccination
Vaccines
Viral load
Viral protein
virus
waning immunity
[DOI] 10.1126/scitranslmed.abm3410 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1126/scitranslmed.abm3410 PMC 바로가기 [Article Type] Research Article