Dysregulated Inflammation as a Risk Factor for Pneumonia in the ElderlyReview Published on 2011-12-022024-09-04 Journal: Aging and Disease [Category] 대상포진, [키워드] aging Inflammation Pneumonia statins Toll-like receptors PMC 바로가기 [Article Type] Review
Role of Exonic Variation in Chemokine Receptor Genes on AIDS: CCRL2 F167Y Association with Pneumocystis PneumoniaAIDS에 대한 케모카인 수용체 유전자의 외음성 변이의 역할: 폐포자충과의 CCRL2 F167Y 연관성Research Article Published on 2011-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI accelerated addition Affect AIDS Amino acid Analysis association associations Atypical Author CCR2 CCR3 CCR5 CCR8 CCRL2 Cell Chemokine receptor chromosome Cluster cohorts conditions CX3CR1 defined dendritic cell disease Disease progression DNA Effect exonic FIVE functional variant functional variants Gene Genes Genetic genetic association Genetic variation genotyped HIV-1 HIV-1 infection host cells Human immune regulation in addition to indicated Inflammation involved key factor lung majority natural history Non-synonymous outcome Pathogenesis Pneumonia progression role Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs surface protein survival survival analysis tested variant Variation [DOI] 10.1371/journal.pgen.1002328 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and ApoptosisResearch Article Published on 2011-10-202022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence activating Activation acute respiratory syndrome addition alleviate Apoptosis apoptotic Author Cell cell metabolism cell stress cells compared contribute contributed control cell different dissemination down-regulated drug drugs E gene E protein elicit envelope enzyme expressing expression Factor Gene Gene Expression homeostasis Host host gene expression identify immunoregulation in vivo increase in Infected Infection Inflammation involved lack mechanisms mutant pathway Pathways potential mechanism proinflammatory Proinflammatory cytokine PROTECT Protein reduced reduction reduction in regulated respiratory respiratory syncytial virus response reversed SARS-CoV SARS-CoV E severe Signal transduction signaling pathway Stress subset Transcription transcription factor treated Treatment unfolded protein response upregulated virus virus production was reduced [DOI] 10.1371/journal.ppat.1002315 PMC 바로가기 [Article Type] Research Article
Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patientsReview Published on 2011-05-282023-06-11 Journal: World journal of gastroenterology [Category] B형 간염, [키워드] Hepatitis B virus hepatitis C virus Inflammation intestine liver [DOI] 10.3748/wjg.v17.i20.2500 PMC 바로가기 [Article Type] Review
Innate immunity and monocyte-macrophage activation in atherosclerosisReview Published on 2011-04-282023-08-30 Journal: Journal of Inflammation (London, England) [Category] E형 간염, [키워드] Atherosclerosis Inflammation Innate immunity Macrophage polarisation Macrophage subtypes monocyte subsets Toll-like receptors [DOI] 10.1186/1476-9255-8-9 PMC 바로가기 [Article Type] Review
Risk factors for intrahepatic cholangiocarcinoma: a possible role of hepatitis B virusOriginal Article Published on 2010-10-012023-06-03 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] aetiology Cholangiocarcinoma Cohort studies Hepatitis Inflammation liver [DOI] 10.1111/j.1365-2893.2009.01243.x PMC 바로가기 [Article Type] Original Article
Original Article: Peroxisome proliferator‐activated receptor and AMP‐activated protein kinase agonists protect against lethal influenza virus challenge in miceOriginal Article Published on 2010-08-172023-06-23 Journal: Influenza and Other Respiratory Viruses [Category] 신종인플루엔자, [키워드] Inflammation Influenza PPAR [DOI] 10.1111/j.1750-2659.2010.00155.x PMC 바로가기 [Article Type] Original Article
Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans갈렉틴-2와 관련된 고지대 파푸아인에서의 심각한 말라리아에 대한 연령 관련 취약성Article Published on 2010-04-122024-08-15 Journal: Nanoscale [Category] 말라리아, [키워드] age cerebral malaria Galectin-2 Gene regulation Inflammation malaria severe malaria [DOI] 10.1086/653125 PMC 바로가기 [Article Type] Article
Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human PrimatesResearch Article Published on 2010-02-052022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome advanced age age analyses Analysis anti-inflammatory action ARDS Author cause Comprehensive contributed coronavirus correlated develop different differential expression diminishe disease displaying exacerbated expression Gene genomic H5N1 host response IFN-β IL-8 in viral increase in individual individuals Infection Inflammation influenza A Innate Intervention life-threatening Lungs macaque macaques Microarray modulation molecular mRNA level NF-κB outcome pandemic pathogen Pathogenesis pathology Pathways Patient primate pro-inflammatory gene expression Protective provide reduce reduced Replication response reveal SARS-CoV SARS-CoV infection severe severe pathology severity shown significantly significantly more syndrome Treatment type I Type I IFN type I interferon viral infection viral replication viral respiratory virus infection virus replication without affecting [DOI] 10.1371/journal.ppat.1000756 PMC 바로가기 [Article Type] Research Article
Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory VirusesResearch Article Published on 2009-09-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accelerate accelerated antibody production Antigen appear Asymptomatic B cell CAGE cause CD4+ T cell clearance described destruction develop different disparate dose ENhance finding functional Host immune response immune response immune responses Immune-mediated Immunity independent Infection Inflammation influenza viruses inherent less limit lung lung damage Lymphoid tissue mechanisms morbidity nanoparticle novel virus pathogen Primary infection primary viral infection protection protective immune response Protein pulmonary viral recruitment Replication respiratory respiratory virus Safe SARS-coronavirus significant decrease significantly significantly increased specificity survival Treatment Vaccination strategies viral antigens viral clearance virus [DOI] 10.1371/journal.pone.0007142 PMC 바로가기 [Article Type] Research Article