Convalescence plasma treatment of COVID-19: results from a prematurely terminated randomized controlled open-label study in Southern SwedenRandomized Controlled Trial Published on 2021-12-042022-10-27 Journal: BMC Research Notes [Category] Coronavirus, COVID-19, SARS, [키워드] 1:1 95% CI addition convalescence convalescent plasma convalescent plasma group convalescent plasma treatment COVID-19 Desaturation died groups hospitalized COVID-19 patient hospitalized patient Inclusion IQR median median time no significant difference objective observational study Open-label oxygen saturation Oxygen therapy Oxygen treatment Patient plasma Primary outcome Randomized randomized controlled study receive Registered Result SARS-CoV2 Standard of care supplementary material survivor therapy Treatment Two patient viral infections with COVID-19 [DOI] 10.1186/s13104-021-05847-7 PMC 바로가기 [Article Type] Randomized Controlled Trial
The Humoral Immune Response to BNT162b2 Vaccine Is Associated With Circulating CD19+ B Lymphocytes and the Naïve CD45RA to Memory CD45RO CD4+ T Helper Cells Ratio in Hemodialysis Patients and Kidney Transplant RecipientsImmunology Published on 2021-12-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] alteration analyzed anti-SARS-CoV2 antibodies antibody production Antibody Response Antibody titer association B cell B cells B lymphocyte baseline BNT162b2 CD19+ CD19+ B lymphocytes CD4+ CD45RA CD45RO Cellular immune response circulating correlation dose first dose flow cytometry fraction helper Hemodialysis humoral Immunosuppressed in both group in both groups kidney transplant recipient kidney transplant recipients lymphocyte material memory memory CD4+CD45RO+ T helper cells naïve CD4+CD45RA+ T helper cells naïve Patient positive correlation provide Ratio recipient response Result SARS-CoV-2 vaccination SARS-CoV2 second dose seronegative seropositive subpopulation T cell T helper cell Transplant vaccination vaccination efficacy vaccine dose vaccine-induced antibody response [DOI] 10.3389/fimmu.2021.760249 PMC 바로가기 [Article Type] Immunology
The influence of interval between doses on response to vaccinesarticle Published on 2021-12-032024-09-02 Journal: Vaccine [Category] 대상포진, [키워드] COVID-19 immunization intervals SARS-CoV2 Vaccines [DOI] 10.1016/j.vaccine.2021.10.050 PMC 바로가기 [Article Type] article
Early Response of CD8+ T Cells in COVID-19 PatientsArticle Published on 2021-12-032022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] apoptotic CD3+ CD8 CD8+ CD8+ T cell CD8+ T cells Cell COVID-19 COVID-19 patient cytokine disease disease course downregulated effector memory FASL faster form Frequency gene expression pattern gene expression profile GNLY granulysin granzyme B granzymes GzmA GzmB GZMK healthy control healthy controls IFN-γ IFN-γ immune response interferon-γ investigated lack Ligand lymphocyte Mild Mild symptom moderate mRNA expression nine Patient perforin Peripheral blood predictor PRF1 progressed progression proportion Protein response SARS-COV-2 infection SARS-CoV2 significantly subpopulation the disease [DOI] 10.3390/jpm11121291 PMC 바로가기 [Article Type] Article
Lockdown impact on age-specific contact patterns and behaviours, France, April 2020Research Published on 2021-12-022022-10-31 Journal: Eurosurveillance [Category] COVID-19, SARS, [키워드] affected age average changed changes in collected conditions conducted Contact convenience sampling country Critical decrease dropped Epidemic Epidemiology Europe evaluate Factor France French Frequency groups healthcare heterogeneity impacted information lockdown Mask modelling National Older participant Participants public health policy reduction reported Result Risk perception SARS-CoV-2 SARS-CoV2 Spread Transmission Transport virus wearing [DOI] 10.2807/1560-7917.ES.2021.26.48.2001636 PMC 바로가기 [Article Type] Research
Immuno-Endocrinology of COVID-19: The Key Role of Sex HormonesCOVID-19의 면역 내분비학: 성 호르몬의 주요 역할Review Published on 2021-12-022022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] Adaptive immune response androgen Clinical studies clinical study coronavirus coronavirus 2019 disease COVID-19 COVID-19 pathogenesis COVID-19 severity Cytopathic effect disease severity element Estrogen Evidence Factor Factors fatality Gender Gene regulation hormone hyper-inflammatory response identify immune response immune responses immuno-endocrinology include Infection Injury involved mechanism optimization Pathogenesis personalised regulated Regulation role SARS-CoV2 severity Sex sex hormone Sex hormones susceptibility target targets therapeutic intervention tissue injury tissue specific Treatment outcome Trial [DOI] 10.3389/fendo.2021.726696 PMC 바로가기 [Article Type] Review
SARS-CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10SARS-COV2 폐렴 회복은 선천적 림프절 세포의 확장과 관련이있다.Article Published on 2021-12-012022-08-31 Journal: European Journal of Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] association CCR10 changes circulating Cohort cohort of patient correlation COVID-19 COVID-19 patient COVID-19 patients e parameters expressing handling hospital Hospital admission ILC ILCs Inflammatory Innate innate lymphoid cell Innate lymphoid cells lung Lung function Lung recovery lymphocyte lymphoid lymphoid cell lymphoid cells marker mucosal oxygenation index pandemic parameters phenotype Pneumonia RAGE Respiratory failure SARS-COV-2 infection SARS-CoV-2 pneumonia SARS-CoV2 subpopulation tissue homeostasis upregulation while [DOI] 10.1002/eji.202149311 PMC 바로가기 [Article Type] Article
Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapiesSARS-CoV2에 대한 체액 보호는 TNF 알파 차단 요법을 받는 환자에서 더 빨리 감소합니다Article Published on 2021-12-012022-09-11 Journal: RMD Open [Category] 변종, 진단, [키워드] Anti-spike anti-Spike IgG anti-TNF Antigen appearance Arthritis blockade booster booster vaccination booster vaccinations CD4+ T cell CD4+ T-cell chronic inflammatory disease chronic inflammatory diseases clinically Cohort controls COVID-19 Critical Decline declined Efficacy faster Frequency greater groups healthy controls healthy individual humoral immune response Humoral response humoral responses IgA level IgA levels IgG immune responses Inflammatory diseases lack mRNA vaccination Necrosis neutralization Neutralizing antibodies no differences pandemic Patient patients persistence receiving regimens response SARS-CoV2 second vaccination significantly T cell therapy TNF TNF alpha Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor inhibitors vaccination vaccine response vaccine responses variants while [DOI] 10.1136/rmdopen-2021-002008 PMC 바로가기 [Article Type] Article
Summary report of seven cases of COVID-19 infection in renal transplant recipients신장이식 수혜자 코로나19 감염 7건 요약 보고Article Published on 2021-12-012022-09-11 Journal: Transplant immunology [Category] MERS, SARS, 진단, 치료제, [키워드] Acute kidney injury adjusted adopted Allograft Antibiotics antiviral drugs Asymptomatic Asymptomatic carrier Asymptomatic carriers clinical manifestations coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Critical critical patients died different clinical manifestations discharged ENhance FIVE Health High-dose Immunity Immunoglobulin Immunosuppressant immunosuppressants immunosuppressive agent Immunosuppressive agents infected with COVID-19 Infection Inflammation inhibit Intravenous immunoglobulin Isolation IVIG low-dose management Methylprednisolone Mild mild patients moderate moderate or severe patients one patient outcome Patient patients with COVID-19 Prognosis recipient reduced rejection renal Renal transplant reported reversal SARS-CoV-2 SARS-CoV2 Seven severe patients therapy treated Treatment was used were used [DOI] 10.1016/j.trim.2021.101445 PMC 바로가기 [Article Type] Article
Drug repurposing in COVID-19: A review with past, present and futureResearch article Published on 2021-12-012022-10-05 Journal: Metabolism Open [Category] 신약개발, 임상, 치료제, [키워드] ACE2 Applying approach approaches approved cause clinical conditions clinical trials conducted coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 disease COVID19 drug Drug repurposing effective Effectiveness ENCODE Favipiravir FDA food Genome global public health host cell surface identify in vitro infection process initiate Interaction molecular docking problems protease inhibitors Protein Protein structure‐based drug design Remdesivir reuse ribavirin Ritonavir RNA virus SARS CoV2 SARS-CoV2 shown single-stranded positive-sense spike structural proteins therapeutic agent Tocilizumab treat [DOI] 10.1016/j.metop.2021.100121 [Article Type] Research article