Identification of Orch3 , a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C자가면역 고환염에 대한 지배적인 내성을 제어하는 유전자좌인 Orch3의 확인, 키네신 계열 구성원 1CResearch Article Published on 2012-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major adjuvants allele alleles animal model Antigen antigen presenting cell antigen presenting cells approach Author Autoimmune Autoimmune disease autoimmune disease susceptibility Autoimmune diseases Autoimmunity autologous characterization chromosome chromosome 11 controlling demonstrated disease disease susceptibility dominant encodes gene etiology exhibiting expression family family member Gene Genetic genetic determinant Genetic predisposition Genome histocompatibility complex identification immunization individual gene individual genes inflammatory disease Kif1c KIF21B KIF5A Kinesin leads loci locus major histocompatibility complex mapped member MHC MHC class MHC class II mice non-infectious orchitis over-expression polymorphism Polymorphisms proliferative Quantitative quantitative trait locus reduced required resistance resistant allele strain susceptibility susceptible T cell T cell responses transcriptional regulation transgenic variety [DOI] 10.1371/journal.pgen.1003140 PMC 바로가기 [Article Type] Research Article
Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary FunctionSNP 및 SNP-by-Smoking 상호 작용의 게놈 전체 공동 메타 분석은 폐 기능에 대한 새로운 유전자좌를 식별합니다Research Article Published on 2012-12-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect analysis applied association Author Autoimmune cigarette smoking compared complex conducted demonstrated differential expression DNER DQB1 Effect Effects European evaluated Evidence evidence of expiratory expressed FEV forced expiratory volume forced vital capacity found function Gene gene region Genetic genetic loci genetic risk factor Genome-wide association studies Genome-wide association study highlight HLA region HLA-DQA2 HLA-DQB1 Human airway epithelium human lung tissue identify implicated Interaction involved joint KCNJ2 loci lung Lung disease measure Meta-analysis meta-analysis meta-analysis model novel nucleotide Phenotypes polymorphism progression pulmonary Pulmonary function Region regions related shown single nucleotide Single nucleotide polymorphism smoker Smokers smoking SNP SNPs SOX9 study participant trait utility vital capacity Volume [DOI] 10.1371/journal.pgen.1003098 PMC 바로가기 [Article Type] Research Article
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophilsResearch Published on 2012-05-292022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] affecting Autoimmune blockade CD4 CD4+ T cells Central nervous system clinical consequence CNS compared complex coronavirus cytokine Demyelination detrimental disease downstream effector molecule Encephalomyelitis expression Factor feedback loops GM-CSF IFN-γ IFN-γ IL-17 independent Infected inflammatory condition inflammatory disease Interaction mechanism memory mice morbidity Mortality murine Neurotropic coronavirus neutrophil neutrophil infiltration Neutrophils not express pathogenic positive PROTECT provided recipient reduced reducing relative contribution rescued response Result survival T cell T cells Th1 Th17 Th17 cell tissue damage Transcription transcriptional regulation transfer upregulation virus was used wild-type [DOI] 10.1186/1742-2094-9-104 PMC 바로가기 [Article Type] Research