Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-upArticle Published on 2020-06-012023-07-13 Journal: The Journal of Infection [Category] SARS, [키워드] Coronavirus infections Pneumonia Prognosis SARS-CoV-2 [DOI] 10.1016/j.jinf.2020.03.019 PMC 바로가기
Pharmacologic Treatments and Supportive Care for Middle East Respiratory SyndromeSynopsis Published on 2020-06-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory distress syndrome antivirals benefit cell line clinical conducted convalescent plasma coronavirus Coronavirus infections Corticosteroids CoV Critical database death effective eligibility Evidence interferon Intravenous immunoglobulin membrane MERS MERS patient MERS patients Middle East Middle East respiratory syndrome moderate mortality rate MOST observational study Pharmacologic protocol reduced respiratory respiratory infections retrieved ribavirin RoB searched Severe acute respiratory syndrome suggested supportive care supportive therapies syndrome systematic review Therapies Treatment Trial unique viruses zoonoses [DOI] 10.3201/eid2606.200037 PMC 바로가기 [Article Type] Synopsis
The association between treatment with heparin and survival in patients with Covid-19Article Published on 2020-05-312022-10-30 Journal: Journal of Thrombosis and Thrombolysis [Category] Coronavirus, MERS, [키워드] 95% CI added adjusted Admission age age and gender association associations Clinical data clinician Combination Community Controlled trial Coronavirus infections covariate COVID-19 died discharged home drug Effect Gender heparin hospital hospitals Hydroxychloroquine IQR logistic regression model lower mortality Mortality oseltamivir oxygen Patient patients Pulmonary embolism recorded remained required Ritonavir Spain Steroids survival temperature therapeutic regime thrombosis Tocilizumab transferred Treatment variable were used [DOI] 10.1007/s11239-020-02162-z PMC 바로가기 [Article Type] Article
Why have nanotechnologies been underutilized in the global uprising against the coronavirus pandemic?Perspective Published on 2020-05-282022-10-30 Journal: Nanomedicine [Category] COVID-19, MERS, SARS, [키워드] absence adjuvant Antigen antiviral therapeutics approach assays carrier coronavirus Coronavirus infection Coronavirus infections COVID-19 diagnostics example gold human coronaviruses immunochromatographic Infectious disease interface nanoparticle nanotechnologies Nanotechnology notable Pandemics Prophylaxis Research SARS-CoV-2 Spike protein Treatment Vaccine [DOI] 10.2217/nnm-2020-0163 PMC 바로가기 [Article Type] Perspective
Fighting the Host Reaction to SARS-COv-2 in Critically Ill Patients: The Possible Contribution of Off-Label DrugsImmunology Published on 2020-05-272022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 2019 coronavirus disease ACE2 activating acute respiratory distress acute respiratory syndrome addition Admissions alveolar ARDS binding caused coronavirus Coronavirus infections COVID19 cytokine develop drug enzyme Evidence expressed Factor Fighting flu glycoprotein IFNγ IL-4 IL10 IL1B Ill Immune cell immune response immunosuppressive drug increase in infected patients Inflammation intensive care interstitial interstitial pneumonia involved IP10 macrophages majority MCP1 multiorgan failure offlabel drug use other molecule Patient peptides Pneumocytes pro-inflammatory cytokines PRR reaction reported Symptom syndrome therapeutic option therapeutic target tissue Vasoactive virus [DOI] 10.3389/fimmu.2020.01201 PMC 바로가기 [Article Type] Immunology
Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial중증 COVID-19 성인 환자에 대한 정맥 주사 렘데시비르의 효능 및 안전성 평가: 무작위 배정, 이중 맹검, 위약 대조, 다기관 임상 3상 연구 프로토콜Study Protocol Published on 2020-05-242022-09-10 Journal: Trials [Category] MERS, SARS, 비임상, [키워드] Administered Administrative information Adult patients Antiviral assigned asymptomatic infection breath category caused China Clinical efficacy Clinical improvement clinical manifestation clinical manifestations clinical status clinical trial concern conducted coronavirus disease Coronavirus disease 2019 Coronavirus infections Coronaviruses COVID-19 COVID-19 virus death defined discharge double-blind Efficacy Efficacy and safety Emergency enrolment event futility GS-5734 Health Organization highly pathogenic hospital in vitro in vivo experiments include Infection inhibitory inhibitory effect Inhibitory effects interim analysis Intravenous remdesivir intravenously laboratory-confirmed MERS-CoV Mild multicentre nucleoside Ordinal Scale Patient Phase 3 Placebo placebo-controlled placebo-controlled trial Pneumonia primary endpoint protocol Public public health emergency randomization Randomized Randomly Remdesivir reported required Respiratory failure SARS-CoV SARS-CoV-2 virus severe COVID-19 severe pneumonia severe viral pneumonia Spread Standard Study protocol Symptoms Treatment Trial Trial registration upper respiratory symptoms Viral Viral pneumonia virus infection World Health Organization Wuhan [DOI] 10.1186/s13063-020-04352-9 PMC 바로가기 [Article Type] Study Protocol
COVID-19 e Estado de Hipercoagulabilidade: Uma Nova Perspectiva TerapêuticaPonto de Vista Published on 2020-05-222022-10-28 Journal: Arquivos Brasileiros de Cardiologia [Category] COVID-19, SARS, [키워드] Anticoagulantes/uso terapêutico Anticoagulants/therapeutic use Betacoronavirus Catastrophic Illness Complicações Cardiovasculares Complications, Cardiovasculares Coronavirus infections COVID-19 COVID-2019 Doença Catastrófica Infecções por Coronavirus Nova Pandemias Pandemics Pneumonia viral Thrombophilia Trombofilia Viral, Pneumonia [DOI] 10.36660/abc.20200308 PMC 바로가기 [Article Type] Ponto de Vista
Does Vitamin D play a role in the management of Covid-19 in Brazil?Comment Published on 2020-05-222022-10-29 Journal: Revista de Saúde Pública [Category] Coronavirus, MERS, SARS, [키워드] Acute respiratory infection Adequate Brazil Coronavirus infections ecological epidemiological highlight Hypothesis Hypovitaminosis D Infectious disease Italian Italy literature review management Older pandemic plasma Prevalence Prevention & control protective role raise Randomized controlled trial Respiratory system respond review serum shown therapeutic Vitamin D vitamin D levels Vitamin D status women [DOI] 10.11606/s1518-8787.2020054002545 PMC 바로가기 [Article Type] Comment
Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2Research Paper Published on 2020-05-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] 24 hours acute respiratory distress ARDS cause caused CD3+ CD4+ CD8+ T lymphocyte changes in chemokine coding Coronavirus infections COVID-19 Critical current cytokine cytokine profile Cytokine storm death demonstrated disease dry cough elevated fatigue Fever global pandemic highlight IFN-α2 IFN-γ IL-10 IL-1α IL-1β IL-6 IL-7 immune factor indicated infection process infiltration interferon lymphocyte Lymphocytes MERS-CoV modulation monocyte NK cell Patient patients with COVID-19 Pneumonia resulting SARS-CoV SARS-CoV-2 significantly syndrome T cells the cytokine storm treated Treatment [DOI] 10.18632/aging.103101 PMC 바로가기 [Article Type] Research Paper
Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19Review Published on 2020-05-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] activity acute respiratory syndrome affecting antiviral therapy clinical trial Consensus coronavirus coronavirus disease coronavirus epidemics Coronavirus infections COVID-19 COVID-19 therapy cysteine proteases drugs DUBs enzyme evaluated expressed function host cell host’s immune response immune response IMPROVE in vitro Infection inhibitor innate immune response intrinsic ISG15 majority Modification multifunctional opportunity outbreak pandemic Papain-like protease Pathogenesis pathway patient survival Pleiotropic effects PLP PLP inhibitors polypeptides Prevent protease Protein Proteins regulate Regulatory required responsible SARS SARS-CoV2 second Spread stability target proteins therapeutic strategy treat Treatment ubiquitin Viral pneumonia viral replication [DOI] 10.3390/ijms21103492 PMC 바로가기 [Article Type] Review