Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCRHLA-A*02:01에서 제시한 지배적인 SARS-CoV-2 스파이크 유래 에피토프의 분자 기반은 공공 TCR에서 인정했습니다.Article Published on 2021-10-032022-09-11 Journal: Cells [Category] MERS, SARS, 변종, [키워드] activate antibodies Basis binding CD8+ T cell CD8+ T cells clearance complex COVID-19 recovered COVID-19 recovered patients Critical dominant epitope epitope presentation help HLA-A HLA-A*02:01 immune system individual individuals Interaction lack molecular basis peptide Public public TCR recognition SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus Structure structures T cell T cell receptor T cells TCR the SARS-CoV-2 virus Viral virus while X-ray crystallography YLQ peptide [DOI] 10.3390/cells10102646 PMC 바로가기 [Article Type] Article
Thymus Gland: A Double Edge Sword for CoronavirusesReview Published on 2021-10-022022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activate antibody Antiviral B lymphocyte CD4+ CD8+ Cell cell proliferation cellular immunity contributing to COVID-19 cytokine Deformity Diseases downregulating dynamic programming edge Endocrine ENhance epithelial lining epitope function hedging Hormones Humoral immunity identity IFN IFNγ IgG subclasses IgG1 IgG3 IL-4 immune immune system Immunity Immunoglobulin induce infected cells Inflammatory diseases inflammatory factors limit lymphoid mechanism N proteins natural killer organ phagocytosis Plasma cell post-decision state variable predicted prevention of COVID-19 promote receptors regulate Regulatory T cell responsible resulting Risk management SARS-CoV secrete secretion sequence susceptibility Sword T cell T cells Th2 therapeutic strategy thymic thymocyte thymus transaction costs virus virus spread [DOI] 10.3390/vaccines9101119 PMC 바로가기 [Article Type] Review
Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants항체 칵테일은 SARS-CoV-2 및 SARS-CoV-2 변이체에 대해 광범위한 중화 활성을 나타냅니다.Article Published on 2021-10-012022-09-11 Journal: Virologica Sinica [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 binding activity acute respiratory syndrome acute respiratory syndrome coronavirus Against Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) antibodies antibody antibody cocktail B.1.1.7 B.1.351 B.1.617 binding binding activity binding antibodies Broad neutralization Clinical treatment cocktail conformational convalescent coronavirus COVID-19 patient domain Donor E484K Endemic enzyme epitope immune India indicated L452R linear multiple mutation multiple mutations Mutation N501Y neutralization neutralize Neutralizing activity outbreak overlapped precipitated provided RBD RBD-binding antibody residue residues respiratory risk SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) therapeutic therapeutic antibodies variant variants Viral viral escape [DOI] 10.1007/s12250-021-00409-4 PMC 바로가기 [Article Type] Article
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19 Research Published on 2021-10-012022-10-05 Journal: Nature Immunology [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome Algorithms antibody Antibody binding assays children clinical disease control patient coronavirus correlated COVID-19 cytokine demonstrated disease severity epitope Frame fusion peptide heptad repeat Hospitalized Illness severity immune Infection Inflammatory MIS-C nucleocapsid ORF ORF3a ORF8 parameter pediatric prefusion prognostic Protein representing responses SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 protein SARS-CoV-2-neutralizing antibody serodiagnostic severe coronavirus disease severe COVID-19 syndrome targets Vaccine viral antibody Virus neutralization [DOI] 10.1038/s41590-021-01051-8 [Article Type] Research
Targeting intra-viral conserved nucleocapsid (N) proteins as novel vaccines against SARS-CoVsSARS-COV에 대한 새로운 백신으로서 바이러스 내 보존 된 뉴 클레오 캡시드 (N) 단백질을 표적으로Virology Published on 2021-09-302022-09-01 Journal: Bioscience Reports [Category] SARS, 변종, 진단, 치료법, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus against SARS-CoV anti-N antibodies anti-N antibody antibody B-cell caused CCL5 class conserved conserved regions coronavirus coronavirus disease Coronaviruses CoV COVID-19 CoVs cytokine Cytokines disease effort elevated ELISA assay epitope Evolution exhibited global pandemic host immune system humanized IFN-γ IgG IgG1 IgG2a IgM immune Immunity memory T cell memory T cells mice mouse monoclonal antibody multiple mutation multiple mutations mutant strain Mutant strains mutated virus N-protein nucleocapsid nucleocapsid protein Patient peptide peptides Protein Region respiratory response robust S protein SARS-CoV SARS-CoV-2 sera severe acute respiratory syndrome coronavirus 2 spike Spread stimulate stimulated strain T cells targeting treat vaccination Vaccine vaccine candidate [DOI] 10.1042/BSR20211491 PMC 바로가기 [Article Type] Virology
The use of nanobodies in a sensitive ELISA test for SARS-CoV-2 Spike 1 proteinBiochemistry, Cellular and Molecular Biology Published on 2021-09-302022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] acute respiratory syndrome antibodies Antigen antigen detection antigens Combination coronavirus detect detection Detection limit diagnostic reagents diagnostics domain ELISA ELISA test ELISAs enzyme-linked immunosorbent assay epitope focus-forming unit high affinity high stability IMPROVE inactivated investigated less Ligand nanobodies nanobody point-of-care Protein Research Sandwich sandwich ELISA SARS-CoV-2 Seven site-specific conjugation spike the receptor-binding domain the SARS-CoV-2 the Spike [DOI] 10.1098/rsos.211016 PMC 바로가기 [Article Type] Biochemistry, Cellular and Molecular Biology
EpiSurf: metadata-driven search server for analyzing amino acid changes within epitopes of SARS-CoV-2 and other viral speciesOriginal Article Published on 2021-09-292022-11-01 Journal: Database: The Journal of Biological Databases and [Category] COVID-19, SARS, [키워드] alterations amino acid change amino acid changes change COG-UK Complete COVID-19 curated database distribution drug endpoints epitope Epitopes GenBank Genomics GISAID sequences Immune Epitope Database Influenza Lineage Metadata mutated offer overlapping Population Region SARS-CoV-2 searched selected sequence serological assays Support Vaccines Viral protein Web web application [DOI] 10.1093/database/baab059 PMC 바로가기 [Article Type] Original Article
Development of an Inactivated H7N9 Subtype Avian Influenza Serological DIVA Vaccine Using the Chimeric HA Epitope ApproachResearch Article Published on 2021-09-292023-05-31 Journal: Microbiology Spectrum [Category] Fulltext, 조류인플루엔자, [키워드] Avian influenza virus DIVA vaccine epitope H7N9 subtype peptide microarray [DOI] 10.1128/Spectrum.00687-21 PMC 바로가기 [Article Type] Research Article
Specific CD8 + TCR Repertoire Recognizing Conserved Antigens of SARS-CoV-2 in Unexposed Population: A Prerequisite for Broad-Spectrum CD8 + T Cell ImmunityArticle Published on 2021-09-282022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome adaptive analyzed antibody immunity Antigen Blood broad-spectrum adaptive immunity CD8 CD8+ T cell CDR3 clone Clustering Cohort complementary conserved coronavirus coronavirus disease COVID-19 cross-reactive effort epitope Epitopes Evidence healthy healthy donor help Immunity implementation implicated IMPROVE in vitro individuals membrane memory T cell MHC-I mononuclear cell Mutation naïve neutralization nucleocapsid PBMCs peptide peptides peripheral populations proportion Protein Proteins provide recognizing recovered patient repertoire SARS-CoV-2 selected Sequencing Specific stimulated T cell T cell receptor T cells TCR TCR repertoire TCR sequencing the healthy therapy translational Vaccine variant virus [DOI] 10.3390/vaccines9101093 PMC 바로가기 [Article Type] Article
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodiesCOVID-19 기증자 유래 중화 항체의 하위 집합에 의해 나타나는 사베코바이러스 전반에 걸친 광범위한 교차 반응성Article Published on 2021-09-282022-09-11 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-RBD antibodies Anti-RBD antibody anti-SARS-CoV-2 antibody avidity binding site breadth CDRH3 changes class coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity crosslinking cryo cryo-EM Donor epitope Epitopes exhibited facilitate H-bond interaction neutralization Neutralizing Neutralizing antibodies neutralizing antibody occlude potent RBD RBD-binding antibody RBDs Receptor-binding domain recognize reducing respiratory reveal sarbecovirus SARS-CoV-2 SARS-CoV-2 variants sensitivity spike spike trimer Spike trimer: structural biology structural biology Structure subset trimer Vaccine design variants Viral viral spike Virology virology: X-ray crystallography. X-ray crystallography Zoonotic coronavirus zoonotic coronaviruses zoonotic sarbecovirus [DOI] 10.1016/j.celrep.2021.109760 PMC 바로가기 [Article Type] Article