Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human HepatocytesArticle Published on 2021-11-042023-08-30 Journal: Cells [Category] E형 간염, [키워드] arenavirus coronavirus hepatoma cells Innate immunity interferon liver primary hepatocytes RIG-I RNA virus TLR3 [DOI] 10.3390/cells10113019 PMC 바로가기 [Article Type] Article
Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infectioncGAS에 의한 세포질 염색질 감지는 SARS-CoV-2 감염에서 타고난 면역 반응을 활성화합니다Article Published on 2021-11-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition caused Cell Cell fusion cellular cGAS chromatin contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytoplasmic cytosolic Defense DNA expression Host host antiviral response host antiviral responses host cell host cells host defense host immune system immune system induce infected cells Infectious diseases inhibit innate immune response innate immune system Innate immunity interferon knowledge MAVS mechanism nucleic acids nucleus offer pandemic pathway positive-sense RNA virus pro-inflammatory gene expression recognize reported required respiratory respond RNA virus SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein STING targeting therapeutic treating COVID-19 Trigger Viral viral infection viral replication Viral RNA [DOI] 10.1038/s41392-021-00800-3 PMC 바로가기 [Article Type] Article
Interferon-Lambda Intranasal Protection and Differential Sex Pathology in a Murine Model of SARS-CoV-2 InfectionSARS-CoV-2 감염의 쥐 모델에서 인터페론-람다 비강 내 보호 및 차등 성 병리학Research Article Published on 2021-11-022022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 치료제, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered angiotensin Antiviral antiviral agent blocked bronchial epithelial cell can be used coronavirus COVID-19 Culture decrease disease dissemination dose early stage early stages Efficacy enzyme epithelial cells expressing human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human lung cell human lung cells IFN-λ infected with SARS-CoV-2 Infection Infectious virus inhibit SARS-CoV-2 inhibited interferon Interferon lambda intranasally Lung infection male mice Model morbidity and mortality Mortality mouse model murine model outcome Pathogens pathology Patient primary human bronchial epithelial cells protection protective effect Protective effects reduce respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe symptom Sex significantly tested transgenic mice treat Treatment Viral viral pathogen viral pathogens virus production [DOI] 10.1128/mBio.02756-21 PMC 바로가기 [Article Type] Research Article
Controversies in Treating Chronic Hepatitis B virus: The Role of Hepatitis B Virus DNA and Surface Antigen TiterReview Published on 2021-11-012023-06-13 Journal: Clinics in Liver Disease [Category] B형 간염, [키워드] HBsAg HBV DNA interferon Nucleoside analogues Phase change qHBsAg Stopping therapy Treatment [DOI] 10.1016/j.cld.2021.06.005 [Article Type] Review
Analysis of SARS-CoV-2 haplotypes and genomic sequences during 2020 in Victoria, Australia, in the context of putative deficits in innate immune deaminase anti-viral responses2020년 호주 빅토리아에서 SARS-CoV-2 일배체형 및 게놈 서열 분석Article Published on 2021-11-012022-09-11 Journal: Scandinavian journal of immunology [Category] SARS, 변종, [키워드] ADAR analysed Analysis Anti-viral anti-viral response anti-viral responses APOBEC APOBEC and ADAR deamination motifs Care cascades coronavirus vaccine COVID‐19 COVID‐19 haplotypes curated Data analysis Deamination death deficiency Department described Elderly patient elderly patients Epidemics epidemiological epidemiological data explain expression Genetic genomic sequence Government Haplotype help Human Hypothesis immune implication infected patient Infection innate immune Innate immunity interferon majority Mutagenesis occurred Patient predicted proportion response SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 genome SARS-CoV-2 genomes stimulated Support tested Vaccine development variant Victoria Wave [DOI] 10.1111/sji.13100 PMC 바로가기 [Article Type] Article
Do interferons play a role in COVID-19?인터페론이 COVID-19에서 역할을 합니까?Article Published on 2021-11-012022-09-11 Journal: International journal of clinical practice [Category] SARS, 치료제, [키워드] interferon [DOI] 10.1111/ijcp.14721 PMC 바로가기 [Article Type] Article
Candida spp. co-infection in COVID-19 patients with severe pneumonia: Prevalence study and associated risk factorsObservational Study Published on 2021-11-012022-10-05 Journal: Respiratory medicine [Category] 임상, [키워드] admitted to ICU Aspergillus C. albican Candida candidiasis clinical outcomes Co-infection COVID-19 COVID-19 patient determine develop diagnosis of COVID-19 Escalation Fungal infection ICU IFI Infection interferon isolate mortality rate Patient patients Pneumonia positive presenting Prevalence radiological involvement reported Result risk risk factor SARS-COV-2 infection severe pneumonia submitted suggested systemic systemic Candidiasis systemic steroids tested Tocilizumab Viral pneumonia [DOI] 10.1016/j.rmed.2021.106619 PMC 바로가기 [Article Type] Observational Study
New Treatments for Chronic Hepatitis B Virus/Hepatitis D Virus InfectionReview Published on 2021-11-012023-06-12 Journal: Clinics in Liver Disease [Category] B형 간염, [키워드] Antiviral treatment Bulevirtide Hepatitis Delta interferon Interferon lambda Nucleic acid polymers siRNA [DOI] 10.1016/j.cld.2021.06.011 [Article Type] Review
Antiviral effects of human placenta hydrolysate (Laennec ®) against SARS-CoV-2 in vitro and in the ferret model시험관 내 및 흰 족제비 모델에서 SARS-CoV-2에 대한 인간 태반 가수분해물(Laennec®)의 항바이러스 효과Comparative Study Published on 2021-11-012022-09-11 Journal: Journal of microbiology (Seoul, Korea) [Category] SARS, 치료제, [키워드] addition Antiviral Antiviral effect antiviral effects antiviral efficacy Attenuated Virus caused clinical manifestation COVID-19 COVID-19 pandemic COVID-19 treatment cytokine Cytokines determine determined by disease dose-dependent manner Effect effective FDA-approved drug ferret ferrets Gene Expression group Health health condition Human Hyperferritinemia IFN IFN-α IFN-β IFN-γ IMPROVE in vitro in vivo model Infection inhibited interferon Laennec® lung Lungs MOI mRNA expression nasal Patient PBS Placenta qRT-PCR Remdesivir respiratory tract respiratory tracts Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selective shown TCID therapeutic therapeutic agent treated Treatment type I upregulated Vero Cell Vero cells virus replication virus titer virus titers was determined [DOI] 10.1007/s12275-021-1367-2 PMC 바로가기 [Article Type] Comparative Study
Primary and Acquired Immunodeficiencies Associated With Severe Varicella-Zoster Virus Infections심각한 수두-대상포진 바이러스 감염과 관련된 1차 및 후천성 면역결핍증Article Published on 2021-11-012023-05-31 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Fulltext, 대상포진, 두창, 수두, 홍역, [키워드] Chickenpox immunodeficiency interferon Varicella-zoster Zoster [DOI] 10.1093/cid/ciaa1274 PMC 바로가기