Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models렌티바이러스 벡터를 사용한 비강내 백신은 전임상 동물 모델에서 SARS-CoV-2로부터 보호합니다Article Published on 2021-02-102022-09-12 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, [키워드] Ad5 adenoviral vector animal model approach beta-coronavirus boost boost-target coronavirus disease COVID-19 decrease Deleterious develop Effect Efficacy Evidence expression glycoprotein golden hamsters hamsters immune response immunization Immunoglobulin immunoglobulin A in vivo in vivo Ad5 transduction inhibit Injury intranasal intranasal vaccination lentiviral lentiviral vectors local inflammation log lung Lung inflammation lung viral load mice mucosal mucosal immunity Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody platform Prophylactic PROTECT receptor hACE2 reduce respiratory tract respiratory tract cell respiratory tracts respiratory tracts. SARS-CoV-2 SARS-CoV-2 replication serum systemic the SARS-CoV-2 the Spike vaccination Vaccine vaccine candidate [DOI] 10.1016/j.chom.2020.12.010 PMC 바로가기 [Article Type] Article
Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers감염된 의료 종사자 중 SARS-CoV-2에 대한 중화 항체의 급격한 감소Article Published on 2021-02-082022-09-12 Journal: Nature Communications [Category] MERS, 진단, [키워드] anti-RBD antibody Antibody titers association binding domain boost concerning correlated COVID-19 declines decrease disease onset elicit Evidence HCW healthcare worker humoral humoral immune response IgA IgG IgM immune protection individual Infection prevention maintain measure Mild MONITOR nAb response NAb titer NAb titers NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers onset of symptoms persistence potential risk Prevention and control Rapid RBD recommendation Reinfection required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination significant decrease Support viral infection [DOI] 10.1038/s41467-021-21111-9 PMC 바로가기 [Article Type] Article
Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onsetSARS-CoV-2 항원에 대한 IgG 항체에 대한 직교 면역분석은 면역 반응이 발병 후 4개월 이상 지속된다는 것을 보여줍니다408 Published on 2021-02-022022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 진단, 치료법, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Analysis Anti-spike Antibody testing Antibody titers antigens approach Asymptomatic clinical feature Clinical features Community community setting conducted coronavirus correlation COVID-19 COVID-19 illness COVID-19 infection COVID-19 pandemic Health help humoral immune response IgG IgG antibodies IgG antibody IgG titer IgG titers illness onset immune protection immune response Immunity immunoassay Infection innate and adaptive immunity intensity long-lasting Longevity Middle East Middle East respiratory syndrome morbidity and mortality Neutralizing activity Neutralizing antibody titer nucleocapsid orthogonal other coronavirus other coronaviruses pandemic Patient pattern platform Protein public health measure public health measures Receptor binding domain Research respiratory S1 subunit SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody testing SARS-CoV-2 antigen SARS-CoV-2 antigens severe acute respiratory syndrome Coronavirus severity severity of COVID-19 Significance Spread symptom onset symptomatic patient syndrome the disease understanding vaccination Viral viral antigens virus with COVID-19 [DOI] 10.1073/pnas.2021615118 PMC 바로가기 [Article Type] 408
Potent mouse monoclonal antibodies that block SARS-CoV-2 infectionSARS-CoV-2 감염을 차단하는 강력한 마우스 단일 클론 항체Accelerated Communication Published on 2021-01-302022-09-10 Journal: The Journal of Biological Chemistry [Category] 유전자 메커니즘, 진단, [키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed anti-SARS-CoV-2 antibodies caused cells chimeric clinical setting convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19, Coronavirus disease 2019 Critical disease disease control ELISA ELISA, enzyme-linked immunosorbent assay ERGIC, endoplasmic reticulum–Golgi intermediate compartment global pandemic Hope IF, immunofluorescence immunoassay immunoassays immunofluorescence immunoprecipitation IP, immunoprecipitatio Molecular biology Molecular pathology monoclonal antibodies monoclonal antibody mouse monoclonal antibody neutralize Neutralizing activity neutralizing antibody outbreak potent produced Prophylaxis RBD, receptor-binding domain Region Research respiratory robust RSV, respiratory syncytial virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SDS, sodium dodecyl sulfate severe acute respiratory syndrome Coronavirus spike the antibody therapy variable regions WB, western blotting western blotting Winter [DOI] 10.1016/j.jbc.2021.100346 PMC 바로가기 [Article Type] Accelerated Communication
Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing ResponsesArticle Published on 2021-01-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antigenicity appear approach boost COVID-19 pandemic COVID-19 vaccine disease displaying dose ectodomain effective elicited ELISA geometric highlight immunization immunized mimicking morphology negative-stain electron microscopy neutralization neutralization titer Neutralizing activity neutralizing antibody newcastle disease virus Particle potent prefusion conformation prefusion-stabilized spike prime immunization response S-2P stabilization SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2-neutralizing antibody significantly higher spike Vaccine virus Virus-like particle virus-like particles VLP Week [DOI] 10.3390/vaccines9020073 PMC 바로가기 [Article Type] Article
Intranasal Infection of Ferrets with SARS-CoV-2 as a Model for Asymptomatic Human Infection무증상 인간 감염에 대한 모델로서 SARS-CoV-2를 사용한 흰 족제비의 비강 감염Article Published on 2021-01-152022-09-01 Journal: Viruses [Category] MERS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome amplify Analysis Antibody Response Antibody responses asymptomatic infection Cell coronavirus did not produce ferret ferrets genomic sequence host response Human humoral Humoral response infected with SARS-CoV-2 Infection inoculated inoculum intranasal Model nasal turbinates neuronal cells Neutralizing activity nucleoprotein nucleotide nucleotide substitution olfactory olfactory neuronal cells reached respiratory resulting RNA SARS-CoV-2 Severe acute respiratory syndrome subclinical infection Swab swabs tissues upper respiratory upper respiratory tract Viral Viral protein Viral RNA Viral RNA shedding virus-neutralizing Y453F [DOI] 10.3390/v13010113 PMC 바로가기 [Article Type] Article
Seroepidemiological Survey of the Antibody for Severe Acute Respiratory Syndrome Coronavirus 2 with Neutralizing Activity at Hospitals: A Cross-sectional Study in Hyogo Prefecture, JapanOriginal Research Article Published on 2021-01-142022-10-30 Journal: JMA Journal [Category] COVID-19, [키워드] activity acute respiratory syndrome analyzed antibody Antibody test Blood Clusters collected conducted coronavirus coronavirus 2 coronavirus disease COVID-19 cross-sectional electrochemiluminescence immunoassay enzyme Epidemiology FIVE Government hospital Hyogo immunoassay immunochromatographic Japan Japanese lifted Neutralizing activity neutralizing antibody pandemic Patient positive positive rate required respiratory risk SARS-CoV-2 SARS-COV-2 infection Seroprevalence survey tested the patient [DOI] 10.31662/jmaj.2020-0094 PMC 바로가기 [Article Type] Original Research Article
Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicryACE2 수용체 모방을 통한 SARS-CoV-2 항체 중화Article Published on 2021-01-112022-09-12 Journal: Nature Communications [Category] 진단, [키워드] ACE2 receptor Ad5-hACE2 analyses angles antibodies antibody Antibody neutralization approach binding binding affinity buried surface areas comparison Critical crystal crystal structure crystal structures Disruption effective expressed functional glycoprotein highest binding affinity in vitro infected individuals Infection mechanism mice monoclonal antibodies monoclonal antibody neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody offer RBD receptor ACE2 Receptor binding domain residue SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 infected individuals SARS-COV-2 infection spike glycoprotein surface areas the RBD Trigger triggers understanding Vaccines Viral viral spike [DOI] 10.1038/s41467-020-20501-9 PMC 바로가기 [Article Type] Article
Neutralization assay with SARS-CoV-1 and SARS-CoV-2 spike pseudotyped murine leukemia virionsSARS-CoV-1 및 SARS-CoV-2 스파이크 유사형 쥐 백혈병 비리온을 사용한 중화 분석Methodology Published on 2021-01-042022-09-01 Journal: Virology Journal [Category] 진단, 치료기술, [키워드] Abbott antibody Antibody test antibody tests binding candidate vaccine capsid circumvent comparison Comparisons composed Concordance condition coronavirus COVID-19 detectable Euroimmun expressed firefly luciferase Genome IgG IgG test immunogenicity infected patient infected patients Influenza influenza infection Laboratory leukemia level 2 level 3 luciferase measure MLV murine Murine leukemia virus neutralization Neutralization assay neutralization titer neutralization titers Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing titers offer Particle Patient patients hospitalized plasma Prognostic factor promise pseudotyped Pseudotyped virus pseudovirion pseudovirions pseudovirus pseudoviruses R 2 ranged Receptor binding domain Replication replication-competent SARS-CoV-2 required Result SARS SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein serum serum sample serum samples Siemen Siemens spike spike glycoprotein tested titers Viral diseases virion virus viruses [DOI] 10.1186/s12985-020-01472-1 PMC 바로가기 [Article Type] Methodology
Discrepant Antigen-specific Antibody Responses Causing SARS-CoV-2 Persistence in a Patient Receiving B-cell-targeted Therapy with Rituximab리툭시맙으로 B 세포 표적 치료를 받는 환자에서 SARS-CoV-2 지속성을 유발하는 불일치 항원 특이적 항체 반응Case Reports Published on 2021-01-012022-09-11 Journal: Internal medicine (Tokyo, Japan) [Category] MERS, 진단, 치료기술, 치료법, 치료제, [키워드] antibody Antibody Response B-cell causing clearance comparable COVID-19 highlight humoral immune response humoral immune responses immune responses Kinetics Lymphoid tissue lymphoma magnitude MONITOR mucosa-associated lymphoid tissue Neutralizing Neutralizing activity Neutralizing antibody response persistent RNAemia Pneumonia recipient recipients remained response rituximab SARS-CoV-2 SARS-COV-2 infection serological suffered therapy titer treated unique Viral [DOI] 10.2169/internalmedicine.7884-21 PMC 바로가기 [Article Type] Case Reports