Systems Biology Approaches for Therapeutics Development Against COVID-19COVID-19에 대한 치료제 개발을 위한 시스템 생물학 접근법Review Published on 2020-10-282022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료제, [키워드] Against approach Biology computational modeling coronavirus COVID-19 COVID-19 outbreak database (DB) development Factor Host host–virus interaction immunomics in silico multiomics Pathogenesis pathogenicity proteomics Research System Systems biology the vaccine therapeutic therapeutic drug therapeutic target therapeutic targets Therapeutics transcriptomics Treatment understanding virus [DOI] 10.3389/fcimb.2020.560240 PMC 바로가기 [Article Type] Review
Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patientsResearch Article Published on 2020-10-202022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affected Analysis analyzed antimicrobial AZU1 cathepsin caused coronavirus coronavirus disease COVID-19 CTSG death degranulation differentially expressed disease pathology ELANE Elastase highlight Hospitalization identify Infection information Innate innate immune system Interaction molecular MPO Myeloblastin naso-oropharyngeal sample Nasopharyngeal swab NETosis neutrophil degranulation Non-invasive pathway patients PCR PCR positive PCR testing Protein Proteins proteomics provide PRTN3 Sample SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients significantly statistically significant swab sample System TCN1 upregulated [DOI] 10.1371/journal.pone.0240012 PMC 바로가기 [Article Type] Research Article
Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19Research article Published on 2020-10-202022-10-05 Journal: Immunity [Category] SARS, 바이오마커, [키워드] alteration Biomarker Biomarkers Coagulation Cohort combinations contribute coronavirus disease COVID-19 COVID-19 patients degranulation ELISA enzyme-linked immunosorbent global public health host response identify immune independent Inflammatory responses knowledge metabolism Mild non-survivor outcomes pandemic Pathogenesis pathophysiological Pathways plasma plasma proteomics Platelet potential therapeutic target predicted Protein Proteins proteomics SARS-CoV-2 severe symptoms survivor [DOI] 10.1016/j.immuni.2020.10.008 [Article Type] Research article
A high-stringency blueprint of the human proteomePerspective Published on 2020-10-162022-10-04 Journal: Nature Communications [Category] 바이오마커, [키워드] cancers Community Complete Coverage creating Diagnosis disease Diseases ENhance Health highlighting Human implication International knowledge Metrics molecular Molecular medicine organization Precision Protein proteome Proteomic analysis proteomics Release subsequent Treatment [DOI] 10.1038/s41467-020-19045-9 PMC 바로가기 [Article Type] Perspective
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samplesArticle Published on 2020-10-152022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 임상, [키워드] Activation Angiogenesis approach association Bioinformatics analysis biological processe Blood coagulation caused Cell cellular metabolism changes in Characteristics clinical sample COVID-19 COVID-19 pandemic COVID-19 pathogenesis Deceased detect differentially expressed dysregulation Extensive feature health emergency high mortality immune response Infection Infectious diseases Inflammatory factor involved lung lung tissue lung tissues microenvironment molecular molecular mechanism NF-κB signaling outlined pathological patients with COVID-19 Pneumonia Protein proteome proteomic proteomics provided Quantitative Regulation SARS-COV-2 infection severe pneumonia therapeutic target upregulated variety virus inactivation was used [DOI] 10.1038/s41392-020-00355-9 PMC 바로가기 [Article Type] Article
Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 InfectionPharmacology Published on 2020-10-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activated antiviral activity arginine residue arginine residues bioinformatics caused cellular Concentration conserved coronavirus COVID-19 COVID-19 disease cysteine residue domain domains Doxorubicin drug effective vaccine Efficacy Evidence examined expected functional global pandemic glyoxalase inactivation Infection interactions MERS metabolite methylglyoxal Modification oxidative paclitaxel physiological system predicted produced producing proteome proteomics Quantitative reactive reactive oxygen specy residue ROS SARS-CoV SARS-CoV-2 selective susceptible targets the SARS-CoV-2 the spike protein therapeutic therapy Toxicity Treatment virucidal vulnerability [DOI] 10.3389/fphar.2020.585408 PMC 바로가기 [Article Type] Pharmacology
Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomicsLetter Published on 2020-10-032022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, MERS, SARS, [키워드] Factor identification Molecular biology Predictive Predictive markers progression proteomics Severe COVID-19 pneumonia [DOI] 10.1038/s41392-020-00333-1 PMC 바로가기 [Article Type] Letter
Benchmarking evolutionary tinkering underlying human–viral molecular mimicry shows multiple host pulmonary–arterial peptides mimicked by SARS-CoV-2Article Published on 2020-10-022022-10-04 Journal: Cell Death Discovery [Category] 유전자 메커니즘, [키워드] ALOX5AP Analysis ANXA7 Benchmarking binding coronavirus strain COVID-19 pathogenesis Environmental microbiology expressed follow-up study functional Helicase HLA-B*40:02 Host human lung human protein identity immune evasion Immunity implicated implication Infection initial MERS molecular nucleic acid observation PAM peptide PGD Proteins proteome proteomics SARS-CoV SARS-CoV-2 SARS-CoV-2 evolution scRNA-seq significantly single-cell RNA-seq tissue viruses zoonosis [DOI] 10.1038/s41420-020-00321-y PMC 바로가기 [Article Type] Article
Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic EnterocolitisArticle Published on 2020-10-012023-07-06 Journal: Yonsei medical journal [Category] SARS, [키워드] angiotensin converting enzyme 2 coronavirus COVID-19 proteomics SARS-CoV-2 [DOI] 10.3349/ymj.2020.61.10.891 PMC 바로가기
Serum proteins may facilitate the identification of Kawasaki disease and promote in vitro neutrophil infiltrationArticle Published on 2020-09-242022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] activated Adhesion Molecule Affect age antibody applied attenuate Biomarkers cause children clinically conducted DEFA1 demonstrated develop Developing Diagnosis diagnostic Diseases ELISA endothelial endothelial cells enrolled evaluate facilitate glycoprotein immune immunology in vitro in vitro study infiltration Inflammatory Kawasaki disease lesion leukocyte Medical research Molecular medicine neutrophil neutrophil infiltration neutrophil surface neutrophil-like cell ORM1 Pathogenesis pathogenic patients potential mechanism potential therapeutic target PRDX2 promote promoted Protein Proteins proteomics reducing responsible rheumatology risk robust S100A12 S100A8 S100A9 Satisfaction serum Serum protein significantly subject Treatment [DOI] 10.1038/s41598-020-72695-z PMC 바로가기 [Article Type] Article