Ensemble bootstrap methodology for forecasting dynamic growth processes using differential equations: application to epidemic outbreaksResearch Article Published on 2021-02-142022-10-28 Journal: BMC Medical Research Methodology [Category] Coronavirus, Fulltext, MERS, [키워드] 95% prediction interval Accuracy boost bootstrap challenge Combination Coverage COVID-19 dataset datasets defined demonstrated Differential equations Ebola Epidemic evaluate evaluated first test Forecasting Generalized logistic growth model Gompertz model growth Infectious disease Influenza interval Interval score methodology Model ensemble, parameter estimation, uncertainty quantification, phenomenological growth outbreak Parametric bootstrapping plague Predictive quantification Randomly Result Richard Richards model Spread supplementary material the epidemic trajectory Transmission model Zika [DOI] 10.1186/s12874-021-01226-9 PMC 바로가기 [Article Type] Research Article
An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2Microbiology Published on 2021-02-122022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 384-well format accelerate acute respiratory syndrome addition antibodies antibody Combination condition coronavirus disease Coronavirus-2 Coronaviruses demonstrated human-to-human transmission immuno-plaque assay (iPA) immunofluorescence methodology Neutralization assay outcome pandemic Plaque assay quantification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 research significantly Spread Viral detection viral quantification [DOI] 10.3389/fmicb.2021.625136 PMC 바로가기 [Article Type] Microbiology
Diagnostic SARS-CoV-2 Cycle Threshold Value Predicts Disease Severity, Survival, and Six-Month Sequelae in COVID-19 Symptomatic Patients진단 SARS-CoV-2 주기 임계값은 COVID-19 증상 환자의 질병 심각도, 생존 및 6개월 후유증을 예측합니다Article Published on 2021-02-112022-09-01 Journal: Viruses [Category] MERS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Clinical management clinical manifestations collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 emergency COVID-19-related death cycle cycle threshold database diagnose diagnoses Diagnosis disease severity FIVE group Hospital admission Hospitalized interview lethality marker median time Mortality Nasopharyngeal swab Novel coronavirus novel coronavirus disease outcomes oxygen oxygen support Patient predict Predictive predictive biomarker prognostic biomarker quantification Randomly required resource respiratory SARS-CoV-2 SARS-CoV-2 swab Sequelae severe acute respiratory syndrome Coronavirus severity Signs and symptoms stratified survival Swab Symptom symptomatic Symptoms value Viral load [DOI] 10.3390/v13020281 PMC 바로가기 [Article Type] Article
Benchmarking virus concentration methods for quantification of SARS-CoV-2 in raw wastewater원폐수 내 SARS-CoV-2 정량을 위한 바이러스 농도 방법 벤치마킹Article Published on 2021-02-102022-09-11 Journal: The Science of the total environment [Category] SARS, 변종, 치료기술, [키워드] Adsorption Benchmarking bovine Bovine corona virus collected Concentration COVID-19 pandemic Efficiency Epidemiology European evaluated Mild Municipal wastewater offer P-value pandemic Pepper mild mottle virus Population qPCR quantification reference standard RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 pandemic SARS-CoV-2 virus sensitivity significantly higher Spread ultracentrifugation Ultrafiltration variant Viral Viral RNA virus Virus concentration method. viruses wastewater [DOI] 10.1016/j.scitotenv.2020.142939 PMC 바로가기 [Article Type] Article
Airborne aerosol olfactory deposition contributes to anosmia in COVID-19공기 중 에어로졸 후각 침착은 COVID-19의 후각 상실증에 기여합니다Research Article Published on 2021-02-052022-09-10 Journal: PLoS ONE [Category] MERS, 치료제, [키워드] aerosol Aerosols Affect airway Anosmia Atypical average blinded bypassing Concentration contribute COVID-19 COVID-19 patients determine droplet dysfunction explain Fluorescein greater Inflammation Inhaled majority mechanism nebulized olfactory olfactory dysfunction Olfactory epithelium opacification Particulate processing provide quantification randomization respiratory respiratory epithelium Result significantly significantly higher subjects subsequent transmission of SARS-CoV-2 upper airway Volunteer [DOI] 10.1371/journal.pone.0244127 PMC 바로가기 [Article Type] Research Article
Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19Article Published on 2021-02-042022-10-04 Journal: Scientific Reports [Category] MERS, 치료기술, [키워드] activate Adsorption alteration assays Biomarkers blockade cough COVID-19 cross-reactivity Degradation determine drug effort European food impede increasingly limit Medicine nasal non-specific other diseases outbreak pathophysiology peptide promote inflammation quantification raised receptor Regulatory Respiratory tract diseases sensitive sensitivity Support [DOI] 10.1038/s41598-021-82191-7 PMC 바로가기 [Article Type] Article
Dynamics of COVID-19 under social distancing measures are driven by transmission network structureResearch Article Published on 2021-02-032022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, [키워드] absence activity adopted applied build can be used Clinical stage condition connection Contact COVID-19 Critical death Decline determine disease driven by Dynamics Effect effective Efficacy Epidemic flat highlight hospitalizations household transmission Impact IMPROVE infected individual Infection infection levels infections interact Interaction Intervention lockdowns mathematical measure Measures occur Outbreaks outcome outcomes Pharmaceutical interventions predict progression quantification reducing Region risk Safe second wave social distancing Social distancing measure Spread spread of COVID-19 suppressed the epidemic the timing Transmission [DOI] 10.1371/journal.pcbi.1008684 PMC 바로가기 [Article Type] Research Article
Trajectory of individual immunity and vaccination required for SARS-CoV-2 community immunity: a conceptual investigationLife Sciences–Mathematics interface Published on 2021-02-032022-10-30 Journal: Journal of the Royal Society Interface [Category] COVID-19, MERS, [키워드] Characteristics Community community immunity costly Decline determine driving effective effort Epidemic health systems Immunity immunized individual infected individual Infection international public health Intervention magnitude Measures morbidity and mortality natural and vaccinal immunity Preexisting immunity probe quantification reduce Reproduction number required risk of infection SARS-CoV-2 social distancing susceptible individual trajectory Transmissibility understanding vaccinal vaccination vaccination rate Vaccine viral life cycle virus [DOI] 10.1098/rsif.2020.0683 PMC 바로가기 [Article Type] Life Sciences–Mathematics interface
VERSO: A comprehensive framework for the inference of robust phylogenies and the quantification of intra-host genomic diversity of viral samplesArticle Published on 2021-01-282022-10-28 Journal: Patterns [Category] COVID-19, [키워드] Abstract acute respiratory syndrome Analysis approach Cluster co-occurrence condition consensus sequences Contact tracing coronavirus COVID-19 COVID-19 pandemic data-driven dataset diffusion epidemiological Evolution Evolution of SARS-CoV-2 explain Frequency genomic Genomic surveillance highlight homoplasies homoplastic variants identify IMPROVE Infection infection chain Intra-host diversity intra-host genomic diversity involved joint limitation limitations mutations outperform pathogen phylogenetic inference Phylogenomics Phylogeny platform Positive selection predict profiles quantification raw sequencing data Research reveal RNA sequencing robust SARS-CoV-2 SARS-CoV-2 consensus sequence SARS-CoV-2 evolution selected sequencing data spike gene Surveillance variant viral evolution viral genomes viral sample Viral variants [DOI] 10.1016/j.patter.2021.100212 PMC 바로가기 [Article Type] Article
Modeling the relative risk of SARS-CoV-2 infection to inform risk-cost-benefit analyses of activities during the SARS-CoV-2 pandemicResearch Article Published on 2021-01-282022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] activities activity Analysis assumption can be used component Contact COVID-19 pandemic estimate events Government group independent Infection modeling outcomes pandemic Participants Probability Public quantification reliability risk risk of infection SARS-COV-2 infection significantly the SARS-CoV-2 [DOI] 10.1371/journal.pone.0245381 PMC 바로가기 [Article Type] Research Article