Using artificial intelligence to improve COVID-19 rapid diagnostic test result interpretation인공 지능을 사용하여 COVID-19 신속한 진단 테스트 결과 해석 개선422 Published on 2021-03-232022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] Classifier clinician color confidence COVID-19 COVID-19 pandemic creating evaluated IMPROVE Interpretation Laboratory machine learning Pathologies Patient positive Precision Rapid diagnostic test RDT RDTs reduce SARS-CoV-2 serological smartphone application [DOI] 10.1073/pnas.2019893118 PMC 바로가기 [Article Type] 422
Characteristics of Children With Kawasaki Disease-Like Signs in COVID-19 Pandemic: A Systematic ReviewPediatrics Published on 2021-03-182022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] Admission C-reactive protein carried Case report Case series children Clinical characteristics clinical outcomes Cohort studies Computed tomography COVID-19 COVID-19 outbreak COVID-19 pandemic diagnosed diagnosed with COVID-19 Efficacy erythrocyte sedimentation rate evaluate ferritin finding Hyperinflammatory hyponatremia incidence Inflammatory intensive care involved Kawasaki Laboratory lymphopenia MIS-C offer outcome Pathogenesis Patient polymerase chain prevalent recent required Respiratory outcome review serological shown SIGN significantly Symptoms syndrome systematic review Treatment Web of Science WoS [DOI] 10.3389/fped.2021.625377 PMC 바로가기 [Article Type] Pediatrics
Nomogram for prediction of fatal outcome in patients with severe COVID-19: a multicenter study중증 COVID-19 환자의 치명적인 결과 예측을 위한 노모그램: 다기관 연구Multicenter Study Published on 2021-03-172022-09-12 Journal: Military Medical Research [Category] 진단, [키워드] 95% CI Admission Analysis analyzed Blood C-reactive protein Chest computed tomography clinician Coagulation Cohort COVID-19 COVID-19 patient CRP death develop effective enrolled Factor help high risk hospital identify IL-6 IMPROVE independent indicated interleukin-6 Laboratory test Liver function Lymphocyte count Mortality multicenter multivariate nomogram observation outcome oxygen saturation Patient patients PCT predict prediction Probability procalcitonin Prognosis prognostic pulse receiving reduce renal function Result routine blood tests sensitivity serological severe coronavirus disease severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient severe patients specificity supplementary material survival Tocilizumab treatment strategy validation cohort validation cohorts was measured [DOI] 10.1186/s40779-021-00315-6 PMC 바로가기 [Article Type] Multicenter Study
Genetic testing and serological screening for SARS-CoV-2 infection in a COVID-19 outbreak in a nursing facility in Japan일본의 한 요양시설에서 코로나19 발생 시 SARS-CoV-2 감염에 대한 유전자 검사 및 혈청학적 스크리닝Research Article Published on 2021-03-152022-09-01 Journal: BMC Infectious Diseases [Category] 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody test Antibody testing antibody tests Asymptomatic caused Combination conducted coronavirus coronavirus disease COVID-19 COVID-19 outbreak Critical Dementia died epicenter evaluated Fever Genetic healthcare personnel impacted individual individuals infected individuals Infection Japan Mortality Nasopharyngeal swab nasopharyngeal swabs Negative PCR number of infected Nursing facility outbreak PCR PCR positivity PCR testing PCR-positive performed prevalent quantitative assay respiratory Result SARS-CoV-2 SARS-COV-2 infection serological serological test Serological testing Serological tests severe acute respiratory syndrome Coronavirus Spread supplementary material termination unit [DOI] 10.1186/s12879-021-05972-5 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19SARS-CoV-2 유도 항체는 경증에서 중등도의 COVID-19 코호트에서 6개월 이상 지속됩니다.Original Paper Published on 2021-03-102022-09-10 Journal: Infection [Category] MERS, SARS, 진단, 치료기술, [키워드] age anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies antibody Antibody titer Antibody titers association Cohort COVID-19 detectable disease severity ELISA Follow-up healthcare worker identify IgA IgG IgG antibody IgG response IgM IgM antibodies IgM antibody IgM response IgM responses immune response immune responses increasing age individual inter-individual less Mild Moderate COVID-19 mounted objective onset of symptoms parameter participant PCR-confirmed COVID-19 positive Questionnaires Result robust S protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein serological Serological immune response Severity of disease Spike protein subject supplementary material Symptom Symptoms Variability variations were assessed were measured [DOI] 10.1007/s15010-021-01598-6 PMC 바로가기 [Article Type] Original Paper
Association of Age With Likelihood of Developing Symptoms and Critical Disease Among Close Contacts Exposed to Patients With Confirmed SARS-CoV-2 Infection in ItalyResearch Published on 2021-03-102022-10-29 Journal: JAMA Network Open [Category] COVID-19, SARS, [키워드] 95% CI acute respiratory syndrome age analyzed association children close contact Cluster cohort study Confirmed confirmed COVID-19 case Contact Contact tracing coronavirus coronavirus disease COVID-19 Critical Critical disease death defined develop Developing effective estimate exposure female Fever finding greater group highlight IgG Importance index case individual infected individual Infection intensive care Italian Italy laboratory-confirmed less likelihood lombardy male measure median MOST Nasopharyngeal swab objective Older participant Patient Point positive proportion ranged Relevance respiratory symptom Result resulting risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections selected serological serological assays setting Solid Symptom tested Transmission virus [DOI] 10.1001/jamanetworkopen.2021.1085 PMC 바로가기 [Article Type] Research
Clinical, Serological, Whole Genome Sequence Analyses to Confirm SARS-CoV-2 Reinfection in Patients From Mumbai, IndiaMedicine Published on 2021-03-092022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] absence amino acid sequence analyses Analysis clades clinical collected Comparative COVID-19 criteria downstream duration of illness Evidence functional annotation Genome genome coverage genome variation genomic genomic variation IgG Immunity India individual information mandatory molecular Mumbai Neutralizing Non-synonymous nucleotide Oropharyngeal Patient patients Post-infection Prolonged infection Region Reinfection reported RNA RT-PCR tests S1 RBD SARS-CoV-2 SARS-COV-2 infection sequence Sequencing Seroconversion serological serology specific mutation supported sVNT symptomatic synonymous the SARS-CoV-2 genome upstream viral isolate virus was performed WGS while Whole blood whole genome Whole genome sequencing [DOI] 10.3389/fmed.2021.631769 PMC 바로가기 [Article Type] Medicine
Detection of SARS-CoV-2-specific antibodies via rapid diagnostic immunoassays in COVID-19 patientsCOVID-19 환자에서 신속한 진단 면역분석을 통한 SARS-CoV-2 특이 항체 검출Research Published on 2021-03-092022-09-01 Journal: Virology Journal [Category] SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody asymptomatic patients blood donor Chain Reaction CMIA coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 symptom COVID-19 symptoms cross-reactivity detection diagnosed diagnostic diagnostic test diagnostic testing diagnostic tests efficient ELISA ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays exhibited IgA IgG IgM IgM/IgG immunoassay Infection investigated Microparticle molecular molecular diagnostic tests negative controls nucleocapsid Patient Rapid diagnostic test RDT real-time reverse transcriptase-polymerase chain reaction remained respiratory Result reverse transcriptase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2-specific antibody seasonal coronavirus seasonal coronaviruses sensitivity Sensitivity and specificity serological Seropositivity serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity specimen study period tested were used [DOI] 10.1186/s12985-021-01530-2 PMC 바로가기 [Article Type] Research
Towards Quantitative and Standardized Serological and Neutralization Assays for COVID-19COVID-19에 대한 정량적이고 표준화된 혈청학적 및 중화 분석을 향하여Article Published on 2021-03-082022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] anti-RBD anti-SARS-CoV-2 Antibody titer Antigen approach Benchmarking complementary correlation COVID-19 Critical Cross reactivity cross-reactivity demonstrated diagnostic full-length help HKU1 IgG IgG and IgM IgM IMPROVE MERS monoclonal antibody reference standard Neutralization assay neutralization assays neutralizing antibody titers OC43 quantified Quantitative quantitative assay Quantitative assays quantitative serology assays RBD Receptor binding domain reference standard robust SARS-CoV SARS-CoV-2 virus SARS1 Sensitivity and specificity serological serology serology assay serology assays spike Spike proteins Surveillance the spike protein Vaccine development viruses [DOI] 10.3390/ijms22052723 PMC 바로가기 [Article Type] Article
Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaquesArticle Published on 2021-03-032022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] antibody Cell cellular immunity convalescent current driving follicular full-length S germinal centre highlight homologous or heterologous human clinical trials humans Humoral immunity immunogenic immunogenicity macaque macaques mice moderate multiple pathway neutralisation neutralising Neutralising activity neutralising antibody non-human primates prime-boost regimen protein subunit vaccine RBD Receptor binding domain recombinant S protein SARS-CoV-2 SARS-CoV-2 vaccine serological serum significantly Subunit vaccine the spike protein titre titres Vaccine vaccine candidate Vaccines viral spike [DOI] 10.1038/s41467-021-21665-8 PMC 바로가기 [Article Type] Article