Matrix-Assisted Laser Desorption and Ionization Time-of-Flight Mass Spectrometry Analysis for the Direct Detection of SARS-CoV-2 in Nasopharyngeal Swabs비인두 면봉에서 SARS-CoV-2의 직접 검출을 위한 매트릭스 보조 레이저 탈착 및 이온화 비행 시간 질량 분석 분석Article Published on 2022-03-152022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid anion exchange resin biological molecule biological molecules cartridge Chain Reaction Combination complex contagious coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patients detect detection Diagnostic method digested Direct Evidence flight identify in some inoculated ionization labor-intensive Laser limit of detection mass mass spectrometry Nasopharyngeal swab nasopharyngeal swab specimen Nasopharyngeal swab specimens nasopharyngeal swabs nucleocapsid patients PCR peptide peptides polymerase chain polymerase chain reaction positive result purification purified Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription reverse transcription polymerase chain reaction SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral particle SARS-CoV-2 viral particles SARS-CoV-2-specific peptide SARS-CoV-2-specific peptides selected separated Seven severe acute respiratory syndrome Coronavirus specimen specimens Spectrometry Swab the SARS-CoV-2 trypsin Viral load was performed [DOI] 10.1021/acs.analchem.1c04328 PMC 바로가기 [Article Type] Article
Association of high SARS-CoV-2 RNAemia with diabetes and mortality in critically ill COVID-19 patientsResearch article Published on 2022-03-142022-10-05 Journal: iScience [Category] 치료제, [키워드] antiviral therapy clinical medicine Comorbidities COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient diabete Diabetic digital PCR Inflammation investigated less Mortality multivariable logistic regression Patient patients plasma quantification SARS-CoV-2 SARS-CoV-2 viral load severe COVID-19 patients suggested Viral load viral replication Virology worsening [DOI] 10.1016/j.isci.2022.104075 [Article Type] Research article
Protective Immunity of the Primary SARS-CoV-2 Infection Reduces Disease Severity Post Re-Infection with Delta Variants in Syrian Hamsters1차 SARS-CoV-2 감염의 보호 면역은 시리아 햄스터의 델타 변종으로 재감염 후 질병 심각도를 감소시킵니다Article Published on 2022-03-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] acute respiratory syndrome AY.1 B.1 caused Characteristics characterized coronavirus disease Coronavirus disease 2019 Delta Delta AY.1 delta variant disease disease severity dominant dose Evidence evidence of groups hamster hamsters high viral load Immunity Infection initial interstitial pneumonia K417N K417N mutation lineages Lung disease Mild Mild disease neutralization Neutralizing neutralizing antibody pathogenicity produced re-infected Re-infection Re-infections reduce reduced reduction in Reinfection remained respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 lineage Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 sterilizing immunity Syrian hamsters the disease upper upper respiratory tract variant variants Viral load viral RNA load virus [DOI] 10.3390/v14030596 PMC 바로가기 [Article Type] Article
Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim BladderCOVID-19 모델로 Zebrafish 유충 탐색: 수영 방광에서 SARS-CoV-2 복제 중단 가능성Article Published on 2022-03-112022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료기술, [키워드] abortive infection animal animal model animal models Bath bladder wall bloodstream Brain Cell comparable COVID-19 decrease drug Embryo epithelial cell epithelial cells Evidence evidence of Host human ACE2 immunohistochemistry in some in vitro Infection inoculated interferon lung mammalian microinjection no evidence of organ overexpression pathophysiology Prophylactic SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 RNA several variant several variants similarity swim bladder tested therapeutic type I type I interferon Viral load Viral RNA virus wild-type zebrafish [DOI] 10.3389/fcimb.2022.790851 PMC 바로가기 [Article Type] Article
Modeling the number of people infected with SARS-COV-2 from wastewater viral load in Northwest Spain스페인 북서부의 폐수 바이러스 부하로 인해 SARS-COV-2에 감염된 사람 수 모델링Article Published on 2022-03-102022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] Additive analyzed approach Community COVID-19 epidemic COVID-19 outbreak COVID–19 described develop effective epidemiological epidemiological data Epidemiology Evolution Generalized Generalized Additive Models (GAM) health system individuals Kernel Kernel smoothing LOESS magnitude methodology Model modeling MONITOR number of infected outbreak quantification R 2 Regression regression models RNA SARS-CoV-2 Spain statistical model symptomatic and asymptomatic the epidemic the SARS-CoV-2 Treatment Viral load wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.152334 PMC 바로가기 [Article Type] Article
First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variantsSARS-CoV-2 및 변이체에 대한 강력한 예방 및 치료 효능을 지닌 동급 최초의 삼중특이성 VHH-Fc 기반 항체Article Published on 2022-03-092022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, [키워드] ACE-2 addition antibody Antibody therapy cellular characterized comparable COVID-19 cases COVID-19 pandemic COVID-19 vaccination death Delta demonstrated distribution Drug development Efficacy Efficacy and safety epitope evaluated feature greatly reduce hospitalizations humanized Immunity in vitro in vivo intranasal lead Measures multiple epitope omicron parameter PBS prevented Prophylactic Prophylaxis provided reduced reported safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutants shown tested the vaccine the vaccines therapeutic efficacy Treatment treatment for COVID-19 variant Viral Viral load viral loads while [DOI] 10.1038/s41598-022-07952-4 PMC 바로가기 [Article Type] Article
Infection with the SARS-CoV-2 B.1.351 variant is lethal in aged BALB/c miceSARS-CoV-2 B.1.351 변이체 감염은 노화된 BALB/c 마우스에서 치명적입니다Article Published on 2022-03-092022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age animals B.1.351 B.1.351 variant BALB/c BALB/c mice chemokine chemokines coronavirus Efficacy elicited evaluate exhibited immunology indicated induce infecting Infection Inflammation Inflammatory Inflammatory cytokine Laboratory lung massive mice Microbiology Mild Model Mortality Older Pathogenesis pathogenesis of SARS-CoV-2 pro-inflammatory pro-inflammatory cytokines respiratory Respiratory tract diseases SARS-CoV-2 SARS-CoV-2 B.1.351 variant severe acute respiratory syndrome Coronavirus susceptible sustained Symptom Symptoms the SARS-CoV-2 Therapeutics Vaccine variant Viral Viral load wild-type [DOI] 10.1038/s41598-022-08104-4 PMC 바로가기 [Article Type] Article
Nanobody-Functionalized Cellulose for Capturing SARS-CoV-2SARS-CoV-2 포획을 위한 나노바디 기능화 셀룰로오스Article Published on 2022-03-082022-09-11 Journal: Applied and Environmental Microbiology [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Bacteria binding biological fluid Blood Cellulose cellulose binding domain cellulose binding protein complement complementary complex coronavirus COVID-19 COVID-19 pandemic cytokine Cytokines D614G variant diagnostics domain Efficiency effort exhibited filtration fluids fungi fusion protein help higher infectivity immobilization IMPROVE infected individuals intrinsic lockdowns mandatory mitigate nanobody porous preventative measures proof proof of concept provided pseudoviruses Receptor-binding domain reducing removal SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses sensitivities shown substrate the receptor-binding domain Therapeutic strategies utility vaccination Vaccinations Viral detection Viral load viral spread Viral transmission virus viruses wild type [DOI] 10.1128/aem.02303-21 PMC 바로가기 [Article Type] Article
Replacing quarantine of COVID-19 contacts with periodic testing is also effective in mitigating the risk of transmissionCOVID-19 접점의 검역소를 주기적 테스트로 교체하는 것은 전송 위험을 완화하는데 효과적입니다.Article Published on 2022-03-072022-09-01 Journal: Scientific Reports [Category] MERS, 진단, 치료기술, [키워드] Adding alternative Analysis Antigen Asymptomatic Asymptomatic cases close contact comparable confirmation Contact Contact tracing COVID-19 develop Diseases effective Effectiveness Efficiency evaluate Evolution expected Health care identify infecting Infection infection risk infectiousness lateral flow Mathematics and computing mitigate PCR Population Positive test quarantine quarantine periods reduced reducing risk risk of transmission robust Secondary infection sensitivity symptom onset Transmission transmission rate transmission rates Viral Viral load [DOI] 10.1038/s41598-022-07447-2 PMC 바로가기 [Article Type] Article
Direct comparison of Xpert Xpress, FilmArray Respiratory Panel, Lumipulse antigen test, and RT-qPCR in 165 nasopharyngeal swabs165 Nasopharyngeal Swabs에서 Xpert Xpress, FilmArray 호흡기 패널, Lumipulse 항원 검사 및 RT-QPCR의 직접 비교Research Article Published on 2022-03-042022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 치료기술, [키워드] 95% CI 95% confidence interval Antigen approved automated COVID-19 Ct values diagnostic test diagnostic tests Direct except for exhibited FilmArray high correlation less Lumipulse NAAT Nasopharyngeal swab nasopharyngeal swabs nucleic acid nucleic acid amplification nucleic acid amplification test offer Panel positive Quantitative random random access respiratory Result RT-qPCR RT-qPCR assays SARS-CoV-2 sensitivity specificity Viral Viral load viral loads Xpert Xpress [DOI] 10.1186/s12879-022-07185-w PMC 바로가기 [Article Type] Research Article