A novel mechanism of RNase L inhibition: Theiler’s virus L* protein prevents 2-5A from binding to RNase LResearch Article Published on 2018-04-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] accumulate activate activating Activation Antiviral antiviral response Apoptosis ATP bind binding Cell cellular Central nervous system chimeric contributing to Coronaviruses degrade double-stranded RNA effective enzyme expressing flu IFN in vivo inactive infected cell infected cells Infection inhibit interferon killing mechanism MHV mouse hepatitis virus murine OAS oligomerization pathway Pathways Prevent produced promote Protein Replication RNase these cell triggering upstream Viral protein Viral RNA virus virus replication virus spread [DOI] 10.1371/journal.ppat.1006989 PMC 바로가기 [Article Type] Research Article
San Wu Huangqin Decoction, a Chinese Herbal Formula, Inhibits Influenza a/PR/8/34 (H1N1) Virus Infection In Vitro and In VivoArticle Published on 2018-03-092023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] Influenza virus San Wu Huangqin Decoction Viral load Viral protein [DOI] 10.3390/v10030117 PMC 바로가기 [Article Type] Article
Host transcription factor Speckled 110 kDa (Sp110), a nuclear body protein, is hijacked by hepatitis B virus protein X for viral persistenceArticle Published on 2017-12-152023-06-18 Journal: The Journal of Biological Chemistry [Category] B형 간염, [키워드] chromatin hepatitis B virus (HBV, Hep B) hepatitis B virus protein x (HBx) promyelocytic leukemia nuclear Bodies signal transducers and activators of transcription 1 (STAT1) small ubiquitin-like modifier (SUMO) Speckled 110 kDa (Sp110) type I interferon-response pathway Viral protein [DOI] 10.1074/jbc.M117.796839 PMC 바로가기
Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA ReplicationResearch Article Published on 2017-11-212022-10-29 Journal: mBio [Category] Coronavirus, [키워드] acute respiratory syndrome Affect biogenesis cleavage coexpressed convoluted membranes coronavirus Coronaviruses cytoplasmic electron tomography element Endoplasmic reticulum eukaryote Evidence expressed Formation highlight Human in viral induce lethal infection maturation membrane structure membranes MERS-CoV Middle East MIMIC Mutagenesis nidovirus nidoviruses nonstructural protein nonstructural proteins Nsp3 nsp4 organelle pathogen Pathogens polyprotein positive precursor proliferation Protein proteolytic Replication replication complex replication organelle biogenesis replication structures required Research respiratory respiratory syndrome coronavirus RNA RNA synthesis RNA virus SARS-CoV similarity subunit suggested thought transmembrane transmembrane domains transmembrane protein Vesicle viral double-stranded RNA viral factory Viral protein [DOI] 10.1128/mBio.01658-17 PMC 바로가기 [Article Type] Research Article
Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibodyResearch Article Published on 2017-08-172022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accompanied acute respiratory disease antibody Asymptomatic case asymptomatic infection Betacoronavirus Clinical signs complement confirmed case Contact tracing deaths develop dose-dependent elicited enhanced Human implication increase in individual Infection Inflammation Inflammatory response inoculated intranasal Lung disease Lung inflammation lung lobe MERS-CoV Middle East Mild naïve Neutralizing activity neutralizing antibody Neutralizing antibody response Neutralizing antibody titer New non-neutralizing antibody occur perivascular inflammation Primary infection PROTECT Protein Proteins Pulmonary infection pulmonary inflammation recruitment Reinfection reported respiratory syndrome coronavirus risk serum subsequent transfer Viral antigen viral challenge Viral protein Viral RNA waned while zoonotic [DOI] 10.1371/journal.ppat.1006565 PMC 바로가기 [Article Type] Research Article
The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/MDA5 activationResearch Paper Published on 2017-07-252022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] activate Activation acute respiratory syndrome antiviral response association cellular circumvent coronavirus CoV CoV-infected cells CoVs epidemic diarrhea Human IFN IFN-β IFNs inhibited Innate immunity innate immunity evasion Interaction interferon MDA5 mechanism Melanoma MHV molecular mouse hepatitis virus N protein N proteins Nidovirale nucleocapsid protein PACT PEDV Protein reproductive RIG-I RIG-I/MDA5 SARS-CoV N protein Sendai virus syndrome the N protein turn type I interferon upstream Viral protein virus [DOI] 10.18632/oncotarget.17912 PMC 바로가기 [Article Type] Research Paper
Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirusResearch Article Published on 2017-02-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] alveolar macrophage Alveolar macrophages animal model Antigen bronchial epithelial cells can be used cause caused Cell characteristic Comparative coronavirus CoV DDP4 develop effective entry receptor eosinophil Fatality rate help histopathological histopathological finding humans Inflammatory inflammatory cell inflammatory cell infiltration lung medication MERS MERS-CoV MERS-CoV infection Middle East Necrosis Neutrophils observation oedema Pathogenesis pathogenic pathology pneumocyte Pneumocytes Pneumonia Prophylactic pulmonary lesions respiratory syndrome coronavirus rhesus rhesus macaque severe viral pneumonia syndrome type I Type II pneumocyte Viral protein Viral RNA virus [DOI] 10.1371/journal.pone.0172093 PMC 바로가기 [Article Type] Research Article
In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated ProteinsResearch Article Published on 2017-01-312022-10-29 Journal: mBio [Category] Coronavirus, [키워드] association biochemical carried complexes conserved coronavirus Coronavirus infection Coronaviruses CoV CoV infection CoV protein CoV replication defined determine domain Endoplasmic reticulum enzymatic activity enzyme epitope function genomic RNA help independent Infection interact Interaction interactions involved knowledge membrane MHV mouse hepatitis virus nonstructural protein not affect Nsp12 Nsp15 Nsps P/S polymerase Protein replaced Replication replication complex replicative required RNA RTC Tagged Transcription Viral protein viral replication virus virus replication while [DOI] 10.1128/mBio.02320-16 PMC 바로가기 [Article Type] Research Article
Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress ResponsesResearch Article Published on 2016-10-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Accessory accessory protein activate Activation acute respiratory syndrome antagonistic Antiviral antiviral host response antiviral host responses antiviral response antiviral signaling binding cause cellular conditions coronavirus coronavirus protein curtail Defense described disease dsRNA eIF2α evade expressing expression high mortality rate Host Human IFN-α/β increasingly independent Infection innate response interfere life-threatening Ligand mechanisms MERS-CoV Middle East mild respiratory molecular mechanism motif p4a pathway Pathways phosphorylate PKR platform Prevent Protein protein 4a receptor reported reservoirs respiratory respiratory syndrome coronavirus response SARS-CoV sequestering severe respiratory infection Spread Stress stress granule suppress suppressed therapeutic intervention translation type I interferon viral dsRNA Viral protein virus virus infection viruses [DOI] 10.1371/journal.ppat.1005982 PMC 바로가기 [Article Type] Research Article
Regulation of Stress Responses and Translational Control by CoronavirusReview Published on 2016-07-042022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] association cellular stress response Control coronavirus Coronavirus infection Coronavirus replication eIF2α Endoplasmic reticulum ER stress GADD34/PP1 host cells in viral JNK mechanism modulate nsp1 overcome p38 Pathogenesis Pathways PERK PKR Protein protein synthesis protein translation reduce response responses Stress translational translational control Trigger turn unfolded protein response Viral protein viruses [DOI] 10.3390/v8070184 PMC 바로가기 [Article Type] Review