clinical – Page 417 – Communicable Diseases Research

Clinical and Immune Features of Hospitalized Pediatric Patients With Coronavirus Disease 2019 (COVID-19) in Wuhan, China

Research

Published on 2020-06-032022-10-29
Journal: JAMA Network Open [Category] COVID-19,

A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-032022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 48 hour Admission allergic reaction anticipated application AST/ALT Bacterial infection Bacterial infections blinded block Breast feeding clinical clinical trial Combination concealed conducted Contraception Control COVID-19 COVID-19 patient criteria defined dependent on Desirable diagnostic Diaphragm dissemination dose double blind ECMO Efficacy Efficacy and safety element Endpoint evaluate extracorporeal membrane oxygenation failure female Germany Hospital stay Hydroxychloroquine IL-6-Rezeptor blockade Immunosuppression immunosuppressive therapy IMV independent Inflammation ingredient Injury Inpatient intensive care units interfere Invasive mechanical ventilation investigator investigators less life lung failure mechanical ventilation methotrexate NaCl NIV non-invasive ventilation number objective outcome parallel group parameters participant Participation Pathogenesis Patient patients PCT performed placebo-controlled trial Pneumonia polymerase chain positive Prednisolone produced progression proof protocol Pulmonary function pulmonary inflammation Quality of life randomisation randomised randomised controlled trial recruited reduce Registered respiratory Safe Sample size SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection SAS severe COVID-19 Severe COVID-19 pneumonia Simultaneous single dose status stratified Study protocol sulfasalazine System the patient therapy Tocilizumab Treatment Trial trials Tuberculosis ULN unit Ventilation ventilator ventilator free day ventilator free days VFD Viral hepatitis website
[DOI] 10.1186/s13063-020-04447-3 PMC 바로가기 [Article Type] Letter

Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-032022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 24 hour acute respiratory distress syndrome addition Administered Anakinra anti-IL-1 anti-IL-6 anti-IL-6 receptor antibody Bacterial Belgium binding blinded blockade Blood characterized chest X-ray chimeric clinical Clinical improvement Combination composed Coronavirus infection COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient CT scan death defined discharge dissemination dose drug Effectiveness element EudraCT excluded experimental arm factorial design Fungal infection hospital hospital discharge Hospitalized hospitals hypoxia hypoxic respiratory failure ICU IL-1 IL-6 IL-6 blockade IL-6 receptor interleukin 1 blockade interleukin 6 blockade Intravenous injection Invasive mechanical ventilation LDH lymphopenia mechanical ventilation non-invasive ventilation number objective on mechanical ventilation open label Open-label outcome oxygen Oxygenation paO2/fiO2 participant Participants Patient patients with COVID-19 Phase 3 primary end point protocol randomisation randomised randomised controlled trial randomization Randomized receive receptor recruited recruitment Registered response Sample size Serum ferritin siltuximab standard care Standard of care status Study protocol subcutaneous injection supplemental oxygen syndrome System systemic cytokine systemic cytokine release syndrome Tocilizumab treated Trial usual care was selected Web website
[DOI] 10.1186/s13063-020-04453-5 PMC 바로가기 [Article Type] Letter

Clinical characteristics and outcomes of COVID-19 infection in nine pregnant women: a report from a sub-Saharan African country, Senegal

9명의 임산부를 대상으로 한 코로나19 감염의 임상적 특징과 결과: 사하라 사막 이남의 아프리카 국가, 세네갈의 보고서

Research

Published on 2020-06-022022-09-01
Journal: The Pan African Medical Journal [Category] MERS, 진단,

[키워드] Admission African age All the patient all the patients association average Characteristics clinical Clinical characteristics clinical feature Clinical features Contamination coronavirus cough country COVID-19 COVID-19 infection COVID-19 pneumonia cross-sectional Data collection died Evidence Fever Frequency General population headache hospital Infection median time nine Other outcome Patient PCR predisposition Pregnancy pregnant pregnant women reported Result rhinorrhea SARS-CoV-2 SARS-COV-2 infection Senegal Severe COVID-19 pneumonia susceptible Symptom the patient Treatment two patients underlying diseases women
[DOI] 10.11604/pamj.supp.2020.35.2.23736 PMC 바로가기 [Article Type] Research

The value of clinical parameters in predicting the severity of COVID‐19

Research Article

Published on 2020-06-022022-10-04
Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, 치료제,

COVID-19 and acute pulmonary embolism: what should be considered to indicate a computed tomography pulmonary angiography scan?

Case Report

Published on 2020-06-012022-10-28
Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] COVID-19, SARS,

Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment

Case Report

Published on 2020-06-012022-10-28
Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] COVID-19, MERS, SARS,

[키워드] Characteristics clinical Clinical characteristics Critical glucocorticoid NCP Non-invasive Non-invasive ventilator Novel coronavirus occurred outbreak Patient Pneumonia Symptom therapeutic treated Treatment ventilator Wuhan, China
[DOI] 10.1590/0037-8682-0227-2020 PMC 바로가기 [Article Type] Case Report

Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome

Synopsis

Published on 2020-06-012022-10-31
Journal: Emerging Infectious Diseases [Category] Coronavirus,

[키워드] acute respiratory distress syndrome antivirals benefit cell line clinical conducted convalescent plasma coronavirus Coronavirus infections Corticosteroids CoV Critical database death effective eligibility Evidence interferon Intravenous immunoglobulin membrane MERS MERS patient MERS patients Middle East Middle East respiratory syndrome moderate mortality rate MOST observational study Pharmacologic protocol reduced respiratory respiratory infections retrieved ribavirin RoB searched Severe acute respiratory syndrome suggested supportive care supportive therapies syndrome systematic review Therapies Treatment Trial unique viruses zoonoses
[DOI] 10.3201/eid2606.200037 PMC 바로가기 [Article Type] Synopsis

An evidence mapping and analysis of registered COVID-19 clinical trials in China

Research Article

Published on 2020-06-012022-10-28
Journal: BMC Medicine [Category] COVID-19, SARS,

[키워드] “COVID-19 2019 novel coronavirus Analysis antiviral drug antiviral drugs CCT Characteristics China Chinese clinical Clinical data clinical trial collected Control COVID-19 COVID-19 outbreak Critical current distributions division drugs evaluate evaluated Evidence experimental group Glaxo Hypothesis identify imperative information interquartile range Intervention majority median Medicine nucleic acid Patient performed pilot study platform primary endpoints Primary outcome Primary outcomes public health recruit Registered registry Research Result Sample size severity Smith Study design TCM the disease therapy Traditional Trial trials variety WHO WHO ICTRP
[DOI] 10.1186/s12916-020-01612-y PMC 바로가기 [Article Type] Research Article

COVID-19, Clinical Trials, and QT-Prolonging Prophylactic Therapy in Healthy Subjects: First, Do No Harm

Short communication

Published on 2020-06-012022-10-05
Journal: Journal of the American College of Cardiology [Category] SARS, 임상,

[키워드] clinical clinical trials COVID-19 genetics QT interval sudden cardiac death
[DOI] 10.1016/j.jacc.2020.05.008 [Article Type] Short communication