Medical and Paramedical Care of Patients With Cerebellar Ataxia During the COVID-19 Outbreak: Seven Practical Recommendations of the COVID 19 Cerebellum Task ForceNeurology Published on 2020-05-222022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] acute respiratory syndrome Ageusia Anosmia approach Ataxia Care Central nervous system Cerebellum Confusion Contact coronavirus COVID 19 COVID-19 Deterioration disease emotional Encephalitis Escalation force functions headache Health healthcare providers immunosuppressive therapies intensive care International Intervention involved Isolation maintain medications MOST nasal nausea neurologic Neurological complications neurological sign neurologist Neuron nuclei olfactory outcome pandemic pandemic coronavirus Paramedical Patient patient population presence of comorbidities promote provide recommendation Regulation rehabilitation Respiratory system risk SARS-CoV-2 SARS-CoV2 severe COVID-19 stroke Symptom target Therapies virus vomiting [DOI] 10.3389/fneur.2020.00516 PMC 바로가기 [Article Type] Neurology
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells대유행 완화제 후보의 삼자 조합: 인간 세포에서 SARS-CoV-2 표적의 게놈 유도 추적으로 정의된 COVID-19 대유행의 표적 완화를 위한 약제의 비타민 D, 케르세틴 및 에스트라디올 매니페스트 특성Article Published on 2020-05-212022-09-10 Journal: Biomedicines [Category] 비임상, [키워드] 2019 coronavirus disease ACE2 activity Affect agent Alter analyses Analysis breath build candidate cell types cellular clinical trial clinical trials Combination condition contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic deficiency disease drug drugs drugs and medicinal substance repurposing Effect elements enrichment eriodictyol estradiol experiment expression expression profiling facilitate Follow-up function functions furin FURIN expression FURIN gene GATA5 gene expression profile Gene expression profiles gene expression signature Gene Set Enrichment Analyses gene silencing Genomics GSEA HIF1a high mortality HMGA2 HNF4A Human human body human cell human cells human gene human genes hypothetical identify Immediate Immune cell immune cells Immunosuppression Impact infect Infection Inference inhibitor inhibitors of SARS-CoV-2 INSIG1 interfere Intervention intrinsically Luteolin majority male Mitigation mitigation approaches molecular Mortality observation observational study observations Older overexpression pandemic Panel Patient persistence present property Protein Protein target protein targets Proteins quercetin Randomized randomized clinical trial Regulatory reported repressor required RUNX1 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral selective severity SFTPC smoking Spread SUMMIT drug-docking screen target targets Testosterone the SARS-CoV-2 tissues tracing Transgenic mouse Treatment upstream utility Viral Viral protein Viral proteins virus Vitamin D vitamin D deficiency website [DOI] 10.3390/biomedicines8050129 PMC 바로가기 [Article Type] Article
ACE2: The Key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?Commentary Published on 2020-04-282022-10-28 Journal: Viruses [Category] COVID-19, [키워드] ACE2 ADAM17 Ang-(1-7) B0AT1 blood pressure condition conditions COVID-19 Critical critical condition Demon disease dysfunction explain functions host cell Inflammatory Injury intestinal molecule multi-organ failure offer organ organs Pathogenesis Proteases PROTECT RAAS regulate SARS-CoV-2 SARS-CoV-2 cell Spread the disease the patient the SARS-CoV-2 TMPRSS2 understanding [DOI] 10.3390/v12050491 PMC 바로가기 [Article Type] Commentary
A Review of Salivary Diagnostics and Its Potential Implication in Detection of Covid-19Infectious Disease Published on 2020-04-172022-10-31 Journal: Cureus [Category] COVID-19, [키워드] aerosol-generating procedures antimicrobial effect asked biological fluid biological marker bleeding cause changes in clinical decision clinical monitoring close contact Community coronavirus disease Coronaviruses cost effective defined dentist detection develop development Diagnosis diagnostic diagnostics digestion Disease diagnosis functions greater Health Healthcare professional healthcare worker hospitalized patient hospitals IMPROVE involved nasopharyngeal nasopharyngeal specimen non invasive Non-invasive novel corona virus offer oropharyngeal swab outbreak pandemic Patient Patient care Potential produced Protein Pyrexia Rapid required Research respiratory symptoms respiratory virus respiratory viruses review risk of transmission Safe Saliva salivary salivary diagnostics salivary gland SARS-CoV secretion specimen systemic disease the patient utilised virus [DOI] 10.7759/cureus.7708 PMC 바로가기 [Article Type] Infectious Disease
Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini ReviewCOVID-19에 대한 중간엽 줄기세포 치료의 타당성: 미니 리뷰Review Published on 2020-01-012022-09-11 Journal: Current gene therapy [Category] SARS, 유전자 메커니즘, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome addition Anti-inflammatory anti-SARS-CoV-2 ARDS Complication coronavirus disease Coronavirus disease 2019 COVID-19 CSS current cytokine Cytokine storm Cytokine storm syndrome Cytokine storms drug dysregulated Fatality rate functions immune immune function Immunity infected with SARS-CoV-2 inhibiting Lung injury mesenchymal stem cell Mesenchymal stem cells MINI MSC MSCs organ organs Patient patients potential mechanism reduce regulate Regulatory repair Research respiratory distress restoration review risk Secretome severe complication severe complications Severe patient STEM stem cells syndrome T cell T cells therapeutic effect therapeutic effects tissue tissue damage treating COVID-19 Treatment Vaccine [DOI] 10.2174/1566523220999200820172829 PMC 바로가기 [Article Type] Review
Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistanceAspergillus fumigatus 칼슘 반응성 전사 인자는 스트레스 내성, 독성 및 카스포펀진 내성을 촉진하는 세포벽 구조를 조절합니다Research Article Published on 2019-12-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activated macrophage activated macrophages Activation aspergillosis Aspergillus fumigatus calcineurin calcium calcium metabolism Calcium signaling cause caused Cell cell wall complexity Complicating disease contribute disease disease control drug drug-resistant drugs echinocandin expression functions fungal fungal cell wall fungal cell walls fungal disease gene networks Host host infection humans identify immune response immune responses increasingly Infection influence inhibit inhibitors invasive involved killing life-threatening Localization Lungs Macrophage macrophages mechanism metabolism mice modifications modulating morphology mutant Neutrophils nine osmotic Pathogenesis Pathogens pathway phosphatase polysaccharide pro-inflammatory pro-inflammatory cytokine pro-inflammatory response pro-inflammatory responses promoted reduction in regulate regulated Regulation response responses Screen signaling pathway strain Strains Stress stress response stress response mechanisms stress responses susceptible Tolerance transcription factor transcription factors transcriptomics Treatment turn unique virulence wild-type [DOI] 10.1371/journal.pgen.1008551 PMC 바로가기 [Article Type] Research Article
Evolution of infectious bronchitis virus in the field after homologous vaccination introductionResearch Article Published on 2019-11-092022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] Analysis avian coronavirus bronchitis demonstrated domain driving evaluate Evidence Evolution Frequency functions glycoprotein Health homologous IBV in viral Infectious Bronchitis Virus Intervention involved Molecular epidemiology natural ORF plasticity Protein reported sequence Support vaccination Vaccine vaccine administration Vaccine-induced immunity Vaccines variant variants viral evolution Viral RNA viral surface virus was performed widespread [DOI] 10.1186/s13567-019-0713-4 PMC 바로가기 [Article Type] Research Article
Essential gene deletions producing gigantic bacteria거대 박테리아를 생성하는 필수 유전자 결실Research Article Published on 2019-06-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerated Acinetobacter Analysis antibiotic Antibiotics Bacteria Bacterial Bacterial infections blocked Cell cell wall cell wall synthesis cells cleave consequence conserved creating dead dead cell dead cells deleted Deletion eliminating enzyme Essential feature function functions Genetic Giant giant cell giant cells help hydrolysis identify inactivated independent life lysed lytic transglycosylase mutant mutants Mutation natural transformation osmotic overcome overlapping pathogenic pathway peptide peptidoglycan polymerization precursor predicted produced producing required respond responsible resulting sacculus targets the cell the dead Tn-seq transposon Treatment [DOI] 10.1371/journal.pgen.1008195 PMC 바로가기 [Article Type] Research Article
Evolution of a novel chimeric maltotriose transporter in Saccharomyces eubayanus from parent proteins unable to perform this function이 기능을 수행할 수 없는 모 단백질로부터 Saccharomyces eubayanus의 새로운 키메라 말토트리오스 수송체의 진화Research Article Published on 2019-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive breakpoint bypassing Cell changes in Chimera chimeric classic Deleterious determine domain duplicate gene ectopic recombination epistatic interaction epistatic interactions Evolution example experiment function functional functions gene encoding Gene Expression gene sequence generate genes encoding Genetic hybrid Interaction lack less limit locus MALT malt extract maltose maltotriose mapped molecular multiple mutation multiple mutations occurred overexpressing paralog paralogs performed Point mutation proceed Protein Proteins provide Recombination Research Saccharomyces cerevisiae sequence strain Strains Substitution substitutions sugar Support the cell thought Transport transporter while wild strain wild strains yeast [DOI] 10.1371/journal.pgen.1007786 PMC 바로가기 [Article Type] Research Article
Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoproteinArticle Published on 2019-04-022022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, MERS, [키워드] antibodies antibody antibody-based therapy binding cause coronavirus Critical develop distinct domain domain epitope function functions group Human Human monoclonal antibody humans humoral interfere membrane fusion MERS MERS-CoV mice neutralizing antibody offer passive immunization Protective Receptor binding Receptor binding domain Respiratory disease respiratory syndrome coronavirus sialic acid spike glycoprotein Spike protein viral spike protein virus zoonotic [DOI] 10.1080/22221751.2019.1597644 PMC 바로가기 [Article Type] Article