Evaluating the immunogenicity of gold nanoparticles conjugated RBD with Freund’s adjuvant as a potential vaccine against SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 진단, [키워드] adjuvant Antigen assays BALB/c mice boost candidate candidate vaccine cell-mediated immune response cell-mediated response cloned COVID-19 COVID-19 pandemic COVID-19 vaccine cytokine E. coli ENhance evaluated Evaluating examined expressed Freund's adjuvant global pandemic gold Gold nanoparticle Gold nanoparticles Health Host humoral Humoral immunity Humoral response IFN-γ IgG IgM IgM and IgG immune immune response immune system Immunogenic proteins Incomplete injected interval long-term immune response marker material Nano-vaccines outcome pandemic purified RBD RBD antigen RBD protein repeated SARS-CoV-2 significantly higher stimulate structural protein the RBD protein treatment group Vaccine while [DOI] 10.1016/j.micpath.2022.105687 PMC 바로가기
Humoral immune response to Comirnaty (BNT162b2) SARS-Cov2 mRNA vaccine in Thalassemia Major patientsArticle Published on 2022-09-012022-11-15 Journal: Microbes and infection [Category] COVID19(2023년), SARS, 진단, [키워드] BAU BNT162b2 evaluated HBD healthy blood donor homogeneous humoral Humoral response immune response Major mRNA vaccine Patient Protein SARS-CoV 2 SARS-CoV-2 SARS-CoV-2-specific antibody serological response spike statistically significant statistically significant difference subject Thalassemia major titre two groups vaccinate vaccination Vaccine [DOI] 10.1016/j.micinf.2022.104976 PMC 바로가기
Dynamic Alterations in the Respiratory Tract Microbiota of Patients with COVID-19 and its Association with Microbiota in the GutArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] 바이오마커, [키워드] Actinomyces alteration analyzed Bacteroide Biomarker Candida contributing to coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression determine Diagnosis disease Disease progression disease severity dynamic Enterococcus Fecal sample Gut gut microbiota ICU ICU Patients identify immune response Increases intensive care intensive care unit metagenome microbe microbial Microbiome microbiota mononuclear cell non-ICU pathway Patient patients patients with COVID-19 PBMC Peripheral blood positive correlation reduced respiratory respiratory microbiota. respiratory tract sequenced Significant significantly sputum Stage Streptococcus tract Treatment strategies with COVID-19 [DOI] 10.1002/advs.202200956 PMC 바로가기
Immune response to SARS-CoV-2 vaccination in relation to peripheral immune cell profiles among patients with multiple sclerosis receiving ocrelizumab오크렐리주맙을 투여받는 다발성 경화증 환자의 말초 면역 세포 프로필과 관련된 SARS-CoV-2 백신 접종에 대한 면역 반응Article Published on 2022-09-012022-09-12 Journal: Journal of neurology, neurosurgery, and psychiatry [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adverse event analysed antibodies antibody B cell B cell subset baseline Blood Cell-mediated immunity Clinical data Clinical effect clinical trial correlated courses effective facilitate Follow-up humoral immune response identify IFN-γ IgM Immune cell immune response Immunocompromised patient Immunomodulatory therapies interferon long-lasting median multiple sclerosis parameter Patient patients performed peripheral peripheral lymphocyte Plasma cell positive correlation positively correlated preserved profile receiving required Retrospective study SARS-CoV-2 transmission SARS-CoV-2 vaccination SARS-CoV-2 vaccine severe disease T cell response titre titres treatment regimen vaccinate vaccination vaccine dose were assessed were measured [DOI] 10.1136/jnnp-2021-328197 PMC 바로가기 [Article Type] Article
Humoral response among patients with interstitial lung disease vaccinated with the BNT162b2 SARS-Cov-2 vaccine: a prospective cohort studyObservational Study Published on 2022-09-012022-10-05 Journal: Respiratory Research [Category] SARS, 임상, 진단, [키워드] addition age and sex Anti-inflammatory Anti-inflammatory therapy anti-inflammatory treatments Anti-spike antibody Antibody titer antifibrotic therapy BNT162b2 BNT162b2 vaccine caused Cohort conducted control group dose evaluate evaluated healthy control high risk humoral Humoral response ILD immune response Immunosuppression Interstitial lung disease IPF maintain median Messenger RNA Patient patients patients treated patients with ILD prospective cohort study pulmonary fibrosis Rabin Medical Center SARS-CoV-2 vaccine serology test seronegative seropositive Severe COVID-19 Infection significantly lower the healthy therapy treated Treatment vaccination vaccine dose was reduced [DOI] 10.1186/s12931-022-02155-x PMC 바로가기 [Article Type] Observational Study
Durability of Immune Response After COVID-19 Booster Vaccination and Association With COVID-19 Omicron InfectionArticle Published on 2022-09-012022-11-15 Journal: JAMA Network Open [Category] SARS, 변종, 진단, [키워드] 95% CI age antibody antibody kinetics Antibody titer antibody waning association avidity BNT162b2 BNT162b2 vaccine booster dose COVID-19 delta variant demonstrated dose effective Effectiveness faster Follow-up geometric mean titer greater Health care worker Humoral response IgG IgG level immune response incidence Infection longitudinal cohort study microneutralization mononuclear cell mononuclear cells neutralization neutralizing antibody Older omicron outcome participant Peripheral blood Primary outcome response SARS-CoV-2 second dose secondary outcome sera Strains susceptibility T cell T cell activation tested Transmission Vaccine vaccine dose vaccine doses variant variant of SARS-CoV-2 variants of concern were assessed were used wild type women [DOI] 10.1001/jamanetworkopen.2022.31778 PMC 바로가기
Mutations in spike protein T cell epitopes of SARS-COV-2 variants: Plausible influence on vaccine efficacySARS-COV-2 변이체의 스파이크 단백질 T 세포 에피토프 돌연변이: 백신 효능에 대한 그럴듯한 영향Article Published on 2022-09-012022-09-11 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, [키워드] analyzed approved bioinformatics Bioinformatics analysis CD4+ CD4+ T-cell CD4+ T-cell epitopes CD8+ CD8+ T-cell CD8+ T-cell epitopes circulating clinically Cluster conserved COVID-19 Delta Effect Effectiveness Efficacy epitope Epitopes form HLA HLA-I HLA-II Humoral immunity immune response immune responses in vitro study independent indicated induce infections long term mink mutant mutated Neutralizing antibodies new SARS-CoV-2 observation omicron post vaccination predicted prevalent profile Protein SARS-CoV-2 SARS-CoV-2 variants scrutiny spike Spike protein Strains T cell T cell epitope T cell response T cells T-cell epitopes translate Vaccine variant variants viral particle Zeta [DOI] 10.1016/j.bbadis.2022.166432 PMC 바로가기 [Article Type] Article
Serum and breastmilk SARS-CoV-2 specific antibodies following BNT162b2 vaccine: prolonged protection from SARS-CoV-2 in newborns and older childrenArticle Published on 2022-09-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] addressed anti-S IgG anti-SARS-CoV-2 antibody BNT162b2 BNT162b2 vaccine Breastfeeding breastmilk children collected COVID-19 determine ELISA enzyme-linked immunosorbent first dose IgA IgG immune response Immunoglobulin G lactating women mother mRNA vaccination mRNA vaccine Newborn Older Patient peaked Prospective Study protection Quantitative analysis SARS-CoV-2 SARS-CoV-2 specific antibody second dose Secretory antibody semi-quantitative serum serum IgG Specific spike transmitted vaccination Vaccine were measured women [DOI] 10.1016/j.ijid.2022.06.055 PMC 바로가기
Establishment of the large-scale longitudinal multi-omics dataset in COVID-19 patients: data profile and biospecimenArticle Published on 2022-09-012022-11-16 Journal: BMB reports [Category] 유전자 메커니즘, [키워드] approval B cell BCR Biobank biospecimen clinical collected contribute coronavirus disease COVID-19 COVID-19 infection COVID-19 patient cytokine dataset Diagnosis Disease progression distribution facilitate healthy controls help HLA hospitalized COVID-19 patients immune profiling immune response Infection initial involved laboratory characteristics mechanism methodology molecular mechanism outbreak pandemic Pandemics performed receptor report researcher Sequencing Single-cell RNA sequencing T cell receptor TCR TCR sequencing Treatment understanding Viral genome sequencing WGS whole genome [DOI] 10.5483/BMBRep.2022.55.9.077 PMC 바로가기
A systematic review and meta-analysis of immune response against first and second doses of SARS-CoV-2 vaccines in adult patients with hematological malignancies혈액암이 있는 성인 환자의 SARS-CoV-2 백신 1차 및 2차 접종에 대한 면역 반응의 체계적인 검토 및 메타 분석Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval 95%CI affected affecting anti-CD20 therapy antibody Antibody detection Antibody Response article booster dose booster doses calculated Cancer patients chronic lymphocytic leukemia CLL Complete conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines develop Diagnosis disease doses evaluate first dose Google Google Scholar healthy subject healthy subjects Hematological malignancies Hematological malignancy higher risk highlight highlighting immune response Immunity immunization Immunocompromised immunogenicity immunosuppressive IMPROVE kinase inhibitors less leukemia lowest Lymphocytic leukemia lymphoma malignancy measure Meta-analysis mRNA mRNA-1273 Myeloma Patient Primary outcome response rate SARS-CoV-2 SARS-CoV-2 vaccine second dose secondary outcome Secondary outcomes seropositive Seropositivity severe coronavirus disease solid tumor solid tumors status subgroup subtype systematic review the disease the vaccine tumors tyrosine tyrosine kinase inhibitor tyrosine kinase inhibitors Vaccine vaccine dose vaccine's immunogenicity Web of Science [DOI] 10.1016/j.intimp.2022.109046 PMC 바로가기 [Article Type] Review