Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19증가된 인터루킨-6 및 대식세포 chemoattractant protein-1은 COVID-19의 호흡 부전과 관련이 있습니다Clinical Trial Published on 2020-12-102022-08-13 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] analyzed association AUC benefit best Biomarker Biomarkers blood sample Blood samples clinical Clinical data collected Combination combinations correlated COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines defined FiO2 G-CSF Hospitalization hospitalized patients Human ICU identify IL-1ra IL-6 IL-8 Inclusion Increased Infectious diseases intensive care unit interleukin-6 investigated IP-10 Macrophage MCP-1 MIP-1α P/F PaO2 PaO2/FiO2 ratio Patient Plasma cytokine pro-inflammatory cytokine pro-inflammatory cytokines prospective cohort study recruited Respiratory failure risk ROC analyses ROC analysis SARS-COV-2 infection severe COVID-19 systemic cytokine target targets treated Treatment Treatment strategies [DOI] 10.1038/s41598-020-78710-7 PMC 바로가기 [Article Type] Clinical Trial
Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 InfectionsPublic Health Published on 2020-12-102022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] ACE-2 Activation acute respiratory syndrome administration angiotensin-converting enzyme 2 anti-inflammatory property Arthritis bee bee venom bee venom in clinical trials candidate cellular characterized China complementary complementary medicine and alternative medicine coronavirus COVID-19 and complementary medicine Cytokine storm syndrome disease Efficacy Epidemiological study expression Extracellular H1N1 HIV humoral IFN-γ IgE IgG antibodies IL-6 IL-8 immune system Immunity immunize Inflammation interact interferon-γ interleukin-6 kinase Local management Medicine melittin Neurological diseases NF-κB non-enveloped viruses nuclear offer Pathways pharmokinetics of bee poison Phospholipase A2 Potential proinflammatory cytokines Protein receptor SARS-CoV-2 SARS-CoV-2 (2019-nCoV) SARS-CoV-2 infections suppress therapy TNF-α tumor necrosis factor-α virus [DOI] 10.3389/fpubh.2020.594458 PMC 바로가기 [Article Type] Public Health
The preliminary comparative results between Covid-19 and non-Covid-19 patients in Western ChinaResearch Article Published on 2020-12-092022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] adverse event analyzed ARDS biochemical C-reactive protein carried China Clinical characteristics Clinical data Clustering collected Comparative results Contact coronavirus COVID-19 death elevated epidemiological Epidemiology incidence interleukin-6 lymphocyte Lymphocyte count Negative predictive value no differences Older Patient patients Pneumonia Result RNA sensitivity sputum production suggested Symptom Wuhan [DOI] 10.1186/s12879-020-05680-6 PMC 바로가기 [Article Type] Research Article
Post-transplant patients with COVID-19 associated acute respiratory distress syndrome, a role for Tociluzumab: A case seriesCase Report Published on 2020-12-092022-10-29 Journal: Respiratory Medicine Case Reports [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory distress syndrome, COVID-19 Admission age appear benefit case sery caused characterized Clinical improvement computerized tomography, IL Confirmed COVID-19 infection coronavirus disease of 2019, CT correlated COVID-19 COVID-19 patient Critical care Critically ill cytokine release discharged effective therapy high mortality rate high risk hospital Hypothesis inhibitor intensive care interleukin-6 interleukin, CAR-T cell: chimeric antigen receptor T-cell intubation LIST, ARDS mechanical ventilation moderate Patient patients patients with COVID-19 raising Respiratory failure SARS-CoV-2 supplemental oxygen syndrome the disease Tocilizumab treated [DOI] 10.1016/j.rmcr.2020.101319 PMC 바로가기 [Article Type] Case Report
Lipid Profile Features and Their Associations With Disease Severity and Mortality in Patients With COVID-19Cardiovascular Medicine Published on 2020-12-042022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 95% CI 95% confidence interval Admission alteration Analysis analyzed apoA-1 association AUC C-reactive protein characteristic Concentration conducted correlated COVID-19 COVID-19 patient COVID-19 patients Critically ill deaths demonstrated described disease severity dynamic epidemiological feature HDL-C high-density highest Hospitalization In-hospital in-hospital mortality Inflammation inflammatory states information interleukin-6 Laboratory Lipid lowest Mortality mortality rate Odds ratio Patient patients with COVID-19 predictor profile prospective observational cohort radiological feature serum Severe case severe disease significantly lower survivor were recorded [DOI] 10.3389/fcvm.2020.584987 PMC 바로가기 [Article Type] Cardiovascular Medicine
Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational studyObservational Study Published on 2020-12-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] Coronavirus, Fulltext, MERS, 임상, [키워드] acute respiratory distress analysed ARDS baseline calculate cause Classifier Cohort collected Concentration COVID-19 COVID-19-associated ARDS Critically ill patient Cutoff demographic described died eight Exploratory analysis FIVE Health Hyperinflammatory identify IL-6 inflammatory pathway inspired air intensive care units interleukin-6 IQR laboratory data median Mortality multicentre multiorgan failure Necrosis Older oxygen PaO Patient patients patients with ARDS phenotype Phenotypes point-of-care Prevalence Probability proportion prospective observational study randomised controlled trial receptor recruited severity significantly lower Survivors syndrome systemic inflammation TNFR1 unlikely upregulation was used [DOI] 10.1016/S2213-2600(20)30366-0 PMC 바로가기 [Article Type] Observational Study
Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes심각하고 치명적인 COVID-19에서 사이토카인 상승: 신속한 체계적인 검토, 메타 분석 및 다른 염증 증후군과의 비교Meta-Analysis Published on 2020-12-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, MERS, 바이오마커, [키워드] 95% CI acute respiratory distress acute respiratory distress syndrome antagonists anti-cytokine anti-cytokine therapies comparator comparison Concentration COVID-19 Critical Critical disease cytokine Cytokine release syndrome Cytokine storm description elevated feature group illness immune Inflammatory interleukin-6 Meta-analysis organ dysfunction Patient patients patients with COVID-19 question Rapid reported respiratory distress review Sepsis serum syndrome systematic review the disease Treatment Trial were recorded [DOI] 10.1016/S2213-2600(20)30404-5 PMC 바로가기 [Article Type] Meta-Analysis
Prevalence and Impact of Hyponatremia in Patients With Coronavirus Disease 2019 in New York CityObservational Study Published on 2020-12-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] 95% CI acute renal failure adjusted odds ratio Admission age Analysis assessment association body mass index chi-square tests coronavirus disease correlated discharge home Encephalopathy Exploratory analysis failure Gender Health hospital hyponatremia identify Impact In-hospital death in-hospital mortality increased risk Increasing independent interleukin-6 Invasive mechanical ventilation Kruskal-Wallis laboratory abnormalities laboratory-confirmed measurement mechanical ventilation Mild moderate morbidity and mortality multicenter multivariable logistic regression New York City nonosmotic normonatremia Observational cohort study occur occurred outcome past medical history Patient patients patients with pneumonia predictors Prevalence Primary outcome Probability renal required secondary severity sodium sodium level worsening [DOI] 10.1097/CCM.0000000000004605 PMC 바로가기 [Article Type] Observational Study
HLA and immunological features of SARS-CoV-2-induced Guillain-Barré syndromeCase Reports Published on 2020-12-012023-07-13 Journal: Neurological Sciences [Category] SARS, [키워드] coronavirus COVID-19 Cytokines Guillain-barrè syndrome interleukin-6 interleukin-8 Neurological complications NEUROLOGY Polyradiculoneuropathy [DOI] 10.1007/s10072-020-04787-7 PMC 바로가기 [Article Type] Case Reports
Ferritin levels in patients with COVID-19: A poor predictor of mortality and hemophagocytic lymphohistiocytosisArticle Published on 2020-12-012023-07-13 Journal: International journal of laboratory hematology [Category] SARS, [키워드] COVID-19 Cytokines ferritin hemophagocytic lymphohistiocytosis interleukin-6 [DOI] 10.1111/ijlh.13309 PMC 바로가기