Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection
여러 막 결합 세린 프로테이나제에 의한 SARS-CoV-2 S 단백질 프라이밍은 바이러스 감염력 및 전신 COVID-19 감염을 설명할 수 있습니다
Review
[키워드] α2-AP, α2-antiplasmin
ACE2
ACE2, angiotensin-converting enzyme 2
activate
addition
Affect
causative agent
cause
caused
cell tropism
circulating
clinical observations
Concentration
contribute
coronavirus SARS-CoV-2
Coronaviruses
COVID-19
COVID-19 infection
COVID-19 pandemic
death
determine
effective
Exclusive or
explain
expression
Factor
HAI-1/SPINT1
heart
host cells
Infection
infection rate
information
inhibitor
inhibitors
kidney
kidney damage
kidneys
liver
liver dysfunction
Lungs
MASPs, membrane-associated serine proteinases
membrane fusion
membrane-associated serine proteinases (MASPs)
membrane-bound
MERS, Middle East respiratory syndrome
much higher
myocardial injury
Neurological complications
organ
other organ
other organs
PAI-1, plasminogen activator inhibitor 1
PCI, protein C inhibitor
positive
predominant
proteinase
QM/MD, quantum mechanical/molecular dynamics
receptor
relative
SARS-CoV-1
SARS-CoV-2
SARS-CoV-2 S protein
SARS-CoV-2 spike protein
SARS, Severe acute respiratory syndrome
Sepsis
Serine
serine proteinase
serpins
significantly higher
similarity
spike (S) protein
Spike protein
SPINT1
SPINT2
structure–function relationship
synergy
term
the disease
the patient
the SARS-CoV-2
thrombotic
TMPRSS2
transmembrane
transmission rate
Treatment
uPA, urokinase-type plasminogen activator
Vaccine
viral fusion
viral spike protein
viral spike proteins
[DOI] 10.1074/jbc.REV120.015980 PMC 바로가기 [Article Type] Review
[DOI] 10.1074/jbc.REV120.015980 PMC 바로가기 [Article Type] Review