Proteinuria in COVID-19: prevalence, characterization and prognostic roleCOVID-19의 단백뇨: 유병률, 특성 및 예후 역할Observational Study Published on 2021-01-232022-09-10 Journal: Journal of Nephrology [Category] MERS, 바이오마커, 임상, [키워드] α1-microglobulin adjusted association characterization Concentration COVID-19 creatinine creatinine) evaluated Follow-up Hospitalized Improving Injury investigated Kidney disease marker median Mortality mortality rate observational study patients patients with COVID-19 Prevalence prognostic Proteinuria quantification reached renal function reported Result retrospective single center subgroups subgroups of patient supplementary material Total tubular Tubular proteinuria urinary urinary catheter Urine were measured with COVID-19 [DOI] 10.1007/s40620-020-00931-w PMC 바로가기 [Article Type] Observational Study
A Novel Approach to the Bioluminescent Detection of the SARS-CoV-2 ORF1ab Gene by Coupling Isothermal RNA Reverse Transcription Amplification with a Digital PCR Approach디지털 PCR 접근 방식과 등온 RNA 역전사 증폭을 결합하여 SARS-CoV-2 ORF1ab 유전자의 생물발광 검출에 대한 새로운 접근 방식Article Published on 2021-01-202022-09-10 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] accurate and rapid identification amplification approach bioluminescence caused comparable coupling COVID-19 pandemic detection Detection limit Digital digital PCR system digital RT-LAMP approach dynamic range facilitate global public health improvement LAMP limit of detection novel ORF1ab PCR protocol quantification reaction RNA RT-LAMP RT-LAMP-BART SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 virus the SARS-CoV-2 the SARS-CoV-2 virus Volume [DOI] 10.3390/ijms22031017 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 Reference Standard Quantified by Multiple Digital PCR Platforms for Quality Assessment of Molecular Tests분자 테스트의 품질 평가를 위해 여러 디지털 PCR 플랫폼으로 정량화된 SARS-CoV-2 참조 표준Article Published on 2021-01-192022-09-11 Journal: Analytical Chemistry [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved assays assessment caused Complete Concentration Consensus coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Diagnosis diagnostic Digital digital PCR evaluate genomic in vitro inactivated infected individuals limit of detection median Multiple NATs Novel coronavirus novel coronavirus disease nucleic acid nucleic acid test nucleic acid tests outbreak PCR performed Plasmid plasmids provide Quality Quality control quantification quantified reference reference standard Reference standards Regulatory respiratory RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread Standard Surveillance Test titer treated Viral virus virus particle virus particles [DOI] 10.1021/acs.analchem.0c03996 PMC 바로가기 [Article Type] Article
Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion미세융합 억제 시험: 바이러스 매개 세포-세포 융합의 항체 중화 정량화Research Article Published on 2021-01-152022-09-10 Journal: The Journal of General Virology [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibodies antibody Antibody neutralization Antibody Response Antibody responses Antibody-mediated neutralization applicability bimolecular canonical Cell cell–cell fusion cells characterized complexes consequence convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated enveloped virus fusion fusion protein GFP in vivo induce infected cells Infection inhibit inhibition test lack Live virus mAb mAbs mechanism membrane-bound mFIT monoclonal antibody multinucleated cell multinucleated cells natural infection Neutral neutralization Neutralizing antibodies Nipah virus pathogenic performed PIGS plasma quantification receptor engagement Renilla repertoire reported reporter respiratory respiratory syncytial virus RSV SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus specific antibodies Spike protein Spread Syncytia syncytia formation the cell the spike protein triggering vaccination Vaccine immunization Vaccines Viral viral pathogenesis viral spread virus Virus neutralization viruses [DOI] 10.1099/jgv.0.001506 PMC 바로가기 [Article Type] Research Article
Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina아르헨티나에서 SARS-CoV-2 면역 상태, 혈청 유병률 및 회복기 혈장 평가를 위한 긴급 대응Research Article Published on 2021-01-142022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, 진단, 치료기술, [키워드] acute and convalescent antibody responses antibody antibody kinetics antibody levels antibody quantification Antibody Response Antibody responses Antibody titers assays Asymptomatic Asymptomatic case Asymptomatic cases Author clinical trial clinical trials Combination compassionate use convalescent convalescent plasma country COVIDAR detect Donor donors ELISA ELISA test Emergency end point enzyme-linked immunosorbent enzyme-linked immunosorbent assay epidemiological evaluate Evolution framework generate Guidance health authorities Health care health care workers health institution hospital hospitalized patient hospitalized patients IgG and IgM IgG antibody IgG antibody titer IgG antibody titers IgM IgM and IgG immune response immune responses Immune status infected individual infected individuals information Kinetics Longitudinal studies longitudinal study management median neutralizing antibody titers nursing homes over pandemic Patient plasma positive correlation powerful tool produced profiles protocol protocols provided public health quantification RBD Receptor binding domain robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Seroconversion seroconversion time serologic assay serologic test serologic testing Spike protein standardized protocol standardized protocols symptomatic and asymptomatic Symptomatic patients symptoms onset Therapies therapy trimer was used [DOI] 10.1371/journal.ppat.1009161 PMC 바로가기 [Article Type] Research Article
A novel deep learning-based quantification of serial chest computed tomography in Coronavirus Disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)에서 직렬 흉부 컴퓨터 단층 촬영의 새로운 딥 러닝 기반 정량화Article Published on 2021-01-112022-09-01 Journal: Scientific Reports [Category] 진단, [키워드] benefit calculated Chest computed tomography chest CT scan Chest CT scans Computed tomography Conventional correlation COVID-19 deep learning demonstrated disease severities disease severity estimation faster groups involved lesions moderate Patient performed predicted pulmonary involvement pulmonary lesion pulmonary lesions quantification reached semi-quantitative severe group Severe patient Spearman’s correlation symptom onset Translational research viral infection [DOI] 10.1038/s41598-020-80261-w PMC 바로가기 [Article Type] Article
Quantitative UV-C dose validation with photochromic indicators for informed N95 emergency decontaminationResearch Article Published on 2021-01-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Accuracy COVID-19 Critical demonstrated dose Efficacy Evidence implementation limitation methodology N95 respirator observé optical porous quantification Quantitative receive required Respirator reuse specificity translation Treatment Variation while [DOI] 10.1371/journal.pone.0243554 PMC 바로가기 [Article Type] Research Article
Protective reactive thymus hyperplasia in COVID-19 acute respiratory distress syndromeObservational Study Published on 2021-01-042022-10-04 Journal: Critical Care [Category] 임상, [키워드] acute respiratory distress age appear chest CT scan co-morbidities Coagulopathy Concentration contribute Control control group controls correlated COVID COVID patient Covid patients COVID-19 CRP CT scan CT scans develop Factor forms ICU IL-7 initial investigated lack lower mortality Lung injury lung involvement lymphocyte Mortality nasal Older Other Patient PCR performed Plasma cytokine polymerase chain pulmonary involvement quantification reactive Result SARS-CoV-2 SARS-CoV-2 infected patient scored Sepsis syndrome T cell T cell receptor T lymphocyte thymic thymus Thymus reactivation TREC visceral were measured while with COVID-19 worse prognosis [DOI] 10.1186/s13054-020-03440-1 PMC 바로가기 [Article Type] Observational Study
Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical ReviewReview Published on 2021-01-032022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activated Activation acute distress respiratory syndrome acute respiratory distress addition ARDS bleeding cause clinical evidence clinical manifestation clinical presentation clinician Coagulation coagulation cascade coagulation disorder coagulation factor coagulation tests Coagulopathy coronavirus disease COVID-19 COVID-19 patients Critically ill patient Disseminated intravascular coagulation endothelial endotoxin hemorrhagic event heparin Ill impairment incidence infiltration Inflammatory inhibitors Laboratory Laboratory test marker mechanism microthrombi Necrosis pathophysiology pathway Platelet platelet activation Platelets Protein protein S quantification question Regulatory reported respiratory responsible review risk supportive care syndrome thromboembolic Thromboembolic events thrombosis tissue variety [DOI] 10.3390/jcm10010140 PMC 바로가기 [Article Type] Review
Multiplexed detection and quantification of human antibody response to COVID-19 infection using a plasmon enhanced biosensor platformResearch article Published on 2021-01-012022-10-05 Journal: Biosensors & bioelectronics [Category] SARS, 치료기술, [키워드] antibody Antibody binding Antigen approach binding interaction biosensor Blood correlated COVID-19 COVID-19 antibody tests COVID-19 infection diagnosing diagnostic tests Dilution Efficacy ELISA enzyme evaluated fluorescent human antibody response IgA IgG IgM immunoassay Immunoglobulin immunosorbent interactions isotypes Last linear measure microsphere multiplex nucleocapsid protein pandemic Patient plasmonic platform quantification Quantitative SARS CoV-2 sensitivity serum serum IgG serum sample target test result was used yielding [DOI] 10.1016/j.bios.2020.112679 [Article Type] Research article