Retrospective SARS-CoV-2 IgG screening during the first wave (March-June 2020) of the COVID-19 pandemic in the United Kingdom영국에서 COVID-19 범유행의 첫 번째 물결(2020년 3월-6월) 동안 소급 SARS-CoV-2 IgG 스크리닝Article Published on 2021-10-012022-09-12 Journal: Journal of medical virology [Category] Fulltext, MERS, 진단, [키워드] acute respiratory syndrome Antiviral Antiviral agents asymptomatic individual collected Community coronavirus coronavirus disease COVID-19 COVID-19 pandemic feasible First wave IgG immune immune globulin Immunoglobulin incidence initial local laboratories lockdown lowest Measures NHS offer pandemic Pandemics peaking polymerase chain positive resulting retrospective SARS Coronavirus SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 transmission sera tested Transmission transmission of SARS-CoV-2 Trust United Kingdom university virus virus classification was performed [DOI] 10.1002/jmv.27162 PMC 바로가기 [Article Type] Article
Unmethylated CpG motif-containing genomic DNA fragments of bacillus calmette-guerin improves immune response towards a DNA vaccine for COVID-19메틸화되지 않은 CpG 모티브를 함유한 바실러스 칼멧-게린의 게놈 DNA 단편은 COVID-19에 대한 DNA 백신에 대한 면역 반응을 향상시킵니다Article Published on 2021-10-012022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] 501Y.V2 acute respiratory syndrome acute respiratory syndrome coronavirus addition adjuvant Antibody titers B.1.1.7 Bacillus Calmette-Guérin BALB/c mice BC01 adjuvant caused Cellular immune response coronavirus coronavirus disease coronavirus- COVID-19 CpG disease DNA DNA fragment DNA vaccine effective elicit expressing Genome Genomic DNA humoral immune response immune responses IMPROVE mice neutralize neutralizing antibody Neutralizing antibody titer neutralizing antibody titers pandemic produced respiratory SARS-CoV-2 SARS-CoV-2 spike protein sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein tested the SARS-CoV-2 unmethylated Vaccine vaccine candidate variants [DOI] 10.1016/j.vaccine.2021.08.103 PMC 바로가기 [Article Type] Article
Thrombosis formation after COVID-19 vaccination Immunological Aspects: Review articleReview Published on 2021-09-302022-10-28 Journal: Saudi Journal of Biological Sciences [Category] COVID-19, [키워드] activated Activation acute respiratory distress aggregation alveolar antibody COVID-19 COVID-19 vaccination cytokine deteriorate enzyme Factor heparin-induced thrombocytopenia immunoassay immunological mechanism in some incidence increase increased mortality individual inflammatory cell Inflammatory responses Ischemia microthrombi multiple organ dysfunction Patient PF4 positive reactivity recipient reported resulting review secretion sequence sera SIRS stimulated syndrome systemic inflammatory response thrombosis Thrombotic events tissue tissues Type II pneumocyte vaccination Virus vector widespread [DOI] 10.1016/j.sjbs.2021.09.065 PMC 바로가기 [Article Type] Review
Function Is More Reliable Than Quantity to Follow Up the Humoral Response to the Receptor-Binding Domain of SARS-CoV-2-Spike Protein after Natural Infection or COVID-19 VaccinationArticle Published on 2021-09-302022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] absence anti-S antibody antibodies antibody assay Antibody titer average binding Cohort COVID-19 COVID-19 vaccine declined detectable dose examination function functional humoral humoral immune response IgG titer immune response impacted indicate induce Infection Like MONITOR mRNA mRNA-based naïve subjects natural natural immune response natural infection neutralization Neutralizing activity neutralizing antibody Neutralizing antibody response Novel coronavirus pandemic Patient protection Protein quantified quantity remained response robust SARS-CoV-2 sera seroconverting serology subject subjects subset the SARS-CoV-2 vaccination Vaccine vaccine dose variants of concern viral neutralization Virus neutralization [DOI] 10.3390/v13101972 PMC 바로가기 [Article Type] Article
Targeting intra-viral conserved nucleocapsid (N) proteins as novel vaccines against SARS-CoVsSARS-COV에 대한 새로운 백신으로서 바이러스 내 보존 된 뉴 클레오 캡시드 (N) 단백질을 표적으로Virology Published on 2021-09-302022-09-01 Journal: Bioscience Reports [Category] SARS, 변종, 진단, 치료법, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus against SARS-CoV anti-N antibodies anti-N antibody antibody B-cell caused CCL5 class conserved conserved regions coronavirus coronavirus disease Coronaviruses CoV COVID-19 CoVs cytokine Cytokines disease effort elevated ELISA assay epitope Evolution exhibited global pandemic host immune system humanized IFN-γ IgG IgG1 IgG2a IgM immune Immunity memory T cell memory T cells mice mouse monoclonal antibody multiple mutation multiple mutations mutant strain Mutant strains mutated virus N-protein nucleocapsid nucleocapsid protein Patient peptide peptides Protein Region respiratory response robust S protein SARS-CoV SARS-CoV-2 sera severe acute respiratory syndrome coronavirus 2 spike Spread stimulate stimulated strain T cells targeting treat vaccination Vaccine vaccine candidate [DOI] 10.1042/BSR20211491 PMC 바로가기 [Article Type] Virology
mRNA vaccination in people over 80 years of age induces strong humoral immune responses against SARS-CoV-2 with cross neutralization of P.1 Brazilian variant80세 이상의 사람들에서 mRNA 백신 접종은 P.1 브라질 변이체의 교차 중화와 함께 SARS-CoV-2에 대한 강한 체액성 면역 반응을 유도합니다Research Article Published on 2021-09-292022-09-10 Journal: eLife [Category] SARS, 변종, 진단, [키워드] age antibody Antibody Response Antibody responses BNT162b2 BNT162b2 mRNA vaccine Brazil Cellular immune response cellular response Cellular responses correlated COVID-19 COVID-19 vaccination cross detectable Donor dual effective Efficacy Human humoral humoral immune response Humoral immunity Humoral response immune responses immunosenescence induce Infection Mortality mRNA vaccination mRNA vaccine neutralization neutralization titer neutralization titers Older P.1 P.1 variant Pfizer platform reduced remained risk factor SARS-CoV-2 SARS-COV-2 infection second vaccination sera serological Spike protein Spike-specific cellular immune responses These data trials vaccination Vaccine vaccine response vaccine responses variant Victoria [DOI] 10.7554/eLife.69375 PMC 바로가기 [Article Type] Research Article
Broadly-Neutralizing Antibodies Against Emerging SARS-CoV-2 VariantsSARS-CoV-2 변이체에 대한 광범위 중화 항체Review Published on 2021-09-272022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] (Alpha) (Beta) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha antibody B.1.1.7 B.1.351 B.1.617.2 Beta breadth broadly neutralising antibodies CDR Characteristics Containment convalescent patient Convalescent patients coronavirus cross-neutralization cross-neutralize Delta delta variant development Effect effective escape mutants function Gamma mAb mAbs monoclonal antibodies monoclonal antibody Neutralizing Neutralizing antibodies neutralizing antibody pandemic Patient plasma priority reduced respiratory Sarbecoviruses SARS-CoV-2 SARS-CoV-2 variants sensitivity sera severe acute respiratory syndrome Coronavirus shown therapeutic therapeutic antibodies understanding vaccinated individuals Vaccines variant variants variants of SARS-CoV-2 virus [DOI] 10.3389/fimmu.2021.752003 PMC 바로가기 [Article Type] Review
Impact of Specific N -Glycan Modifications on the Use of Plant-Produced SARS-CoV-2 Antigens in Serological AssaysPlant Science Published on 2021-09-272022-10-31 Journal: Frontiers in Plant Science [Category] COVID-19, [키워드] allergen allergic antibodies antibody Antigen average carbohydrate Cell characterized comparable contribute COVID-19 cross-reactive cross-reactive carbohydrate determinant detect determinant epitope event expressed expression False positive False positives glycosylated glycosylation human cell human sera humans immune response Impact individual Interaction Modification Neutralizing antibodies Nicotiana benthamiana pandemic plant populations posttranslational modification produced RBD reactivity Receptor binding domain reduced required SARS-CoV-2 sera serological assays serological test Specific Spike protein the SARS-CoV-2 Transient variant viral antigens viral infection virus was used while wild-type [DOI] 10.3389/fpls.2021.747500 PMC 바로가기 [Article Type] Plant Science
Preclinical evaluation of a synthetic peptide vaccine against SARS-CoV-2 inducing multiepitopic and cross-reactive humoral neutralizing and cellular CD4 and CD8 responses다에피토프 및 교차 반응성 체액 중화 및 세포 CD4 및 CD8 반응을 유도하는 SARS-CoV-2에 대한 합성 펩타이드 백신의 전임상 평가Research Article Published on 2021-09-272022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] adjuvant alum Amino acid antibody Antibody Response B-cell epitopes BALB/c CD4 CD8 cellular cellular immunity characterization CpG cross-reactive cysteine cysteines displaying dose epitope epitope mapping Epitopes experiment Freund’s Freund’s adjuvant generate hACE2 HLA humanized humoral identification identify immunization infected individual infected individuals K18-hACE2 mice lethal dose linear epitope linear epitopes mice Neutralizing Neutralizing antibodies neutralizing capacity overlapped peptide peptide vaccine peptides Preclinical Protein Proteins RBD Receptor-binding domain recognizing response S protein S proteins SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants sera subunit suggested T-cell epitopes tested the receptor-binding domain titres transgenic mice vaccination Vaccine vaccine platform [DOI] 10.1080/22221751.2021.1978823 PMC 바로가기 [Article Type] Research Article
Sensitivity of SARS-CoV-2 Variants to Neutralization by Convalescent Sera and a VH3-30 Monoclonal Antibody회복기 혈청 및 VH3-30 단클론항체에 의한 중화에 대한 SARS-CoV-2 변이체의 민감도Immunology Published on 2021-09-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody Response B.1.1.7 B.1.351 B.1.617.1 binding activity Brazil caused collected convalescent patient Convalescent patients convalescent sera coronavirus coronavirus disease COVID-19 global pandemic India indicated Intervention mAb mAbs Medical countermeasures neutralization neutralizing capacity neutralizing mAb neutralizing monoclonal antibodies neutralizing monoclonal antibody New Novel coronavirus novel coronavirus disease P.1 pandemic respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera severe acute respiratory syndrome Coronavirus South Africa Spread Vaccine variants VH3-30 VoC VOCs wild-type [DOI] 10.3389/fimmu.2021.751584 PMC 바로가기 [Article Type] Immunology