Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study
브라질에서 코로나 박 코비드 -19 백신의 이전 수용자 (RHH-001)의 이전 수용자에서 이종과 동종 코비드 -19 부스터 백신 접종
Clinical Trial
Published on
Journal: Lancet (London, England) [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, 치료기술,
Journal: Lancet (London, England) [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, 치료기술,
[키워드] 95% CI
Ad26
Ad26.COV2-S
Ad26.COV2-S vaccine
Administered
administration
adverse events
age
All participant
All participants
anti-Spike IgG
anti-spike IgG antibodies
Anti-spike IgG antibody
anti-spike IgG response
Anti-spike IgG responses
Antibody concentrations
assigned
AstraZeneca
AZD1222
B.1.1.529
B.1.617.2
baseline
binding
blind
BNT162b2
boost
booster
booster dose
booster vaccination
Booster vaccine
Brazil
ChAdOx1
ChAdOx1 nCoV-19
ChAdOx1 nCoV-19 vaccine
Concentration
CoronaVac
COVID-19
COVID-19 vaccine
detectable
discharged home
dose
eligible
ENhance
except for
finding
FIVE
for inclusion
four groups
funding
geometric
geometric mean
geometric mean ratio
geometric mean ratios
group
Heterologous
homologous
homologous booster responses
IgG antibody
IgG responses
immune response
immune responses
immunogenicity
IMPROVE
inactivated
Infection
inferiority
janssen
Live virus neutralising antibodies
Local
local and systemic reactogenicity profiles
Ministry of Health
mRNA vaccine
Neutralising Antibodies
neutralising antibody
neutralising antibody titre
neutralising antibody titres
non-inferiority
non-inferiority margin
Older
Older adults
Omicron variant
Omicron variants
outcome
participant
Pfizer
Pfizer–BioNTech
phase 4
primary analysis
Primary outcome
profiles
pseudovirus neutralising antibodies
randomisation
randomised
Randomly
reached
recipient
recombinant adenoviral vectored vaccine
recombinant adenoviral-vectored ChAdOx1 nCoV-19 vaccine
regimen
Registered
RHH-001
robust
secondary
Secondary outcomes
Serious Adverse Events
Seropositivity
significant increase
Sinovac
stratified
systemic reactogenicity
the vaccine
Vaccine
vectored vaccine
virus neutralising antibody
whole-virion SARS-CoV-2 vaccine
[DOI] 10.1016/S0140-6736(22)00094-0 PMC 바로가기 [Article Type] Clinical Trial
[DOI] 10.1016/S0140-6736(22)00094-0 PMC 바로가기 [Article Type] Clinical Trial