Viral load of SARS-CoV-2 in droplets and bioaerosols directly captured during breathing, speaking and coughingArticle Published on 2022-03-032022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acid activity average coughing cycle threshold Determining droplet expiratory Factor identify indicated individual Infectious diseases Infectious virus macroscopic NP swab outcome Plaque assay positively correlated public health Respiratory droplets retrieved risk RNA SARS-CoV-2 SARS-CoV-2 RNA secretion standardized protocol Swab Transmission viral infection Viral load [DOI] 10.1038/s41598-022-07301-5 PMC 바로가기 [Article Type] Article
Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomographyCOVID-19의 임상 소견, 바이러스 부하 및 결과: 초기 흉부 컴퓨터 단층 촬영 음성 및 양성 환자의 비교Comparative Study Published on 2022-03-032022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] addition Admission age AUC characteristic Chest computed tomography Chest CT clinical Clinical characteristics Clinical data Clinical findings confidence interval COVID-19 CRP level Ct value Cutoff Diagnosis Efficacy evaluated examined Fever help Hospital stay initial intensive care intensive care unit admission male mean hospital stay negative and positive Odds ratio Older outcome Patient patients Pneumonia positive receiver operating characteristic report ROC significantly significantly higher tested the mean therapy threshold value Viral load viral loads [DOI] 10.1371/journal.pone.0264711 PMC 바로가기 [Article Type] Comparative Study
Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates비인간 영장류에서 SARS-CoV-2 변이체에 대한 재조합 단백질 소단위 백신 및 불활성화 백신의 면역원성 및 보호 효능Article Published on 2022-03-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 진단, [키워드] ADCC Alpha antibody Antibody titers antibody-dependent cellular cytotoxicity B.1.351 Beta Beta variant binding Breakthrough infection circulating variant COVID-19 vaccine cytokine declined Delta demonstrated domain downregulated effective Efficacy followed by immune memory immunized immunogenicity inactivated Inactivated vaccine increase in Infection Inflammatory cytokine involved lung tissue lung tissues Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer non-human primate omicron Omicron variants Other pathological changes post vaccination Protective protective effect protective mechanism Protein subunit protein subunit vaccine prototype provided RBD Receptor-binding domain reduction respiratory respiratory tracts rhesus macaque rhesus macaques SARS-CoV-2 variant sera significantly Strains Vaccine Vaccines variant Viral Viral load virus VOCs was reduced [DOI] 10.1038/s41392-022-00926-y PMC 바로가기 [Article Type] Article
Gramicidin S and melittin: potential anti-viral therapeutic peptides to treat SARS-CoV-2 infectionGramicidin S 및 Melittin : SARS-COV-2 감염을 치료하는 잠재적 항 바이러스 치료 펩티드Article Published on 2022-03-022022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] Analysis Anti-SARS-CoV-2 Activity Anti-viral Antibacterial Antiviral approach Bacillus brevis candidate Cell Biology COVID19 cytotoxicity de novo decrease drug Drug discovery GRAMICIDIN in vitro indicated Infection less melittin molecules mRNA pandemic peptide peptides post infection Protein regulated SARS-CoV-2 SARS-COV-2 infection Significant significant decrease the disease the SARS-CoV-2 therapeutic treat treated Treatment Vero Cell Vero cells Viral viral clearance viral infections Viral load [DOI] 10.1038/s41598-022-07341-x PMC 바로가기 [Article Type] Article
Performance of colorimetric reverse transcription loop-mediated isothermal amplification as a diagnostic tool for SARS-CoV-2 infection during the fourth wave of COVID-19 in Thailand태국의 코로나19 4차 유행 중 SARS-CoV-2 감염 진단 도구로서의 비색 역전사 루프 매개 등온 증폭 성능Article Published on 2022-03-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] 95% CI accounted acute COVID-19 caused Chain Reaction Colorimetric RT-LAMP Coverage COVID-19 COVID-19 infection cycle threshold diagnostic Diagnostic method diagnostic methods false false-negative false-negative results Infection isothermal amplification LAMP Loop-mediated isothermal amplification Mass screening nasopharyngeal swabs ORF1ab gene Patient performance regions reverse transcriptase reverse transcriptase-polymerase chain reaction reverse transcription RNA sample RT-LAMP RT-PCR RT-PCR assay SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity and specificity specificity Spread variants Viral Viral load Viral RNA virus [DOI] 10.1016/j.ijid.2021.12.351 PMC 바로가기 [Article Type] Article
SARS-CoV-2 rapid antigen test in comparison to RT-PCR targeting different genes: A real-life evaluation among unselected patients in a regional hospital of ItalySARS-CoV-2 신속항원 검사와 다른 유전자 표적 RT-PCR 비교: 이탈리아 지역 병원에서 선별되지 않은 환자를 대상으로 한 실생활 평가Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigen detection Calabria caution Chain Reaction coronavirus Cycling diagnostic Discordance gene target high viral load hospital identify indicated Infection IRCCS Italy molecular test Negative predictive value PanBio Panbio™ COVID-19 Patient polymerase chain reaction positive Positive predictive value Positive test positive test result Predictive value presenting Prevalence processed RAD reverse transcriptase RT-PCR SARS-CoV-2 Sensitivity and specificity severe acute respiratory syndrome Coronavirus shown significantly lower stratified subject Support Swab swabs test result tested threshold Viral load Volume [DOI] 10.1002/jmv.27378 PMC 바로가기 [Article Type] Article
Negative pressure therapy as a safe alternative in the treatment of massive subcutaneous emphysema in critically ill patients COVID-19Case report Published on 2022-03-012022-10-05 Journal: Heart & lung : the journal of critical care [Category] SARS, 치료법, [키워드] approach barotrauma Consensus Contagion COVID-19 COVID-19 pandemic Critical Critically ill patient described effective emphysema Health healthcare personnel increased risk infected patients intensive care intensive care units invasive Invasive mechanical ventilation male management Massive subcutaneous emphysema Minimally invasive techniques MSE Negative pressure Patient performed reducing respiratory infections retained Safe surgical therapeutic therapeutic efficacy therapy tissue treated Treatment Viral load [DOI] 10.1016/j.hrtlng.2022.01.006 [Article Type] Case report
High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trialRandomized Controlled Trial Published on 2022-03-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 임상, 치료법, [키워드] 1:1 age Analysis anti-SARS-CoV-2 IgG assigned baseline convalescent plasma COVID-19 COVID-19 vaccine crowdfunding did not reduce double-blind early treatment Efficacy eligible Endpoint enrolment Euroimmun Evidence experimental group experimental intervention for inclusion Grifols health-care hospitalisation in viral incidence intention-to-treat population intravenous IQR less log Methylene Mild mild COVID-19 symptom monitoring board multicentre Nasopharyngeal swab occurred Older Outpatient participant Patient Placebo placebo-controlled trial plasma Prevent progression random assignment randomisation randomised Randomly receive recommendation reduce Registered reported risk saline solution SARS-CoV-2 viral load Serious Adverse Event severe disease Spain Stratification Support symptom duration the mean Thromboembolic event titre Treatment Trial Viral load was done web-based system with COVID-19 [DOI] 10.1016/S2213-2600(21)00545-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Diagnostic techniques for COVID-19: A mini-reviewCOVID-19 진단 기술: 미니 리뷰Review Published on 2022-03-012022-09-11 Journal: Journal of virological methods [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] Accuracy antigen detection Asymptomatic carrier Asymptomatic carriers auxiliary Combination Computed tomography country COVID-19 COVID-19 diagnostic assay COVID-19 diagnostic assays COVID-19 patient COVID-19 patients CT imaging Diagnosis diagnosis of COVID-19 diagnostic diagnostics Early detection early diagnosis early stage immunological Immunological methods IMPROVE in some indicate Isolation nucleic acid nucleic acid testing nucleic acid tests pandemic positive result presence of antibody qPCR quantitative PCR reported respiratory infectious disease resulting SARS-CoV-2 SARS-CoV-2 virus Serological testing serum antibodies serum antibody Spread symptomatic patient Symptomatic patients the SARS-CoV-2 virus Viral load virus virus detection virus genome Wuhan Wuhan, China [DOI] 10.1016/j.jviromet.2021.114437 PMC 바로가기 [Article Type] Review
Evaluation of a rapid-antigen test for COVID-19 in an asymptomatic collective : A prospective study무증상 집단에서의 코로나19 신속항원검사 평가 : 전향적 연구Article Published on 2022-03-012022-09-11 Journal: Wiener medizinische Wochenschrift (1946) [Category] SARS, 치료기술, [키워드] Antigen antigen detection Asymptomatic average carried Chain Reaction confidence interval COVID-19 COVID-19 patient COVID-19 patients cycle threshold District early stage early stages evaluate hospital mass Mass screening over performed point of care point-of-care testing polymerase chain polymerase chain reaction positive positive result Prospective Study Rapid Rapid antigen tests Real-Time Reverse Transcription Polymerase Chain Reaction Real-time reverse transcription polymerase chain reaction. resource reverse transcription reverse transcription polymerase chain reaction Roche Diagnostics RT-PCR RT-PCR tests SARS-CoV‑2 sensitivity Sensitivity and specificity significant increase specificity Swab Symptom tested the mean treated Viral load viral loads was done [DOI] 10.1007/s10354-021-00883-1 PMC 바로가기 [Article Type] Article