Avian Influenza Virus Infection of Immortalized Human Respiratory Epithelial Cells Depends upon a Delicate Balance between Hemagglutinin Acid Stability and Endosomal pHArticle Published on 2015-04-242023-06-02 Journal: The Journal of Biological Chemistry [Category] 조류인플루엔자, [키워드] Avian influenza virus endosomal pH endosome epithelial cell hemagglutinin membrane fusion tropism Viral protein virus entry [DOI] 10.1074/jbc.M114.611327 PMC 바로가기
Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expressionArticle Published on 2014-11-262022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] accumulating acute respiratory syndrome antiviral responses biological function common conserved coronavirus CoV CoV infection CoVs determine downregulation Evidence Factor function functional highly pathogenic Host host gene expression human coronavirus inhibit innate immune response knowledge mammalian Middle East modulate mRNA cleavage nonstructural protein 1 novel nsp1 Pathogenesis Protein provide Regulation RNA viruses SARS SARS Coronavirus syndrome translation inhibition unique Vaccine development viral gene expression Viral protein virulence [DOI] 10.1016/j.virusres.2014.11.019 PMC 바로가기 [Article Type] Article
Spherules and IBVCommentary Published on 2014-09-012022-10-27 Journal: Bioengineered [Category] Coronavirus, [키워드] bronchitis candidate cell interaction cellular membrane complexes coronavirus cross-protection Culture cultured cells double membrane vesicles Ex vivo IBV identify infecting Infection Infectious Bronchitis Virus membrane membrane rearrangements organ positive primary cell replication site Research RNA virus RNA viruses spherule spherules Structure Vaccine Variation Viral protein virus virus attenuation virus replication virus strain while [DOI] 10.4161/bioe.29323 PMC 바로가기 [Article Type] Commentary
Coronavirus virulence genes with main focus on SARS-CoV envelope geneArticle Published on 2014-08-022022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activated activated T cell activating Activation acute respiratory distress Adaptive immune response addressed Affect animal model antagonist Apoptosis ARDS attenuate B cell binding cause cellular cellular pathway coronavirus CoV CoV genome CoV infection CoV protein cytokine death deleted deletion mutant described disease disease severity domain driver E protein edema elicit elicited envelope gene envelope protein exacerbated Host Host immune response humans IFN immune response immunopathological induce Infection inflammasome activation Inflammation Inflammatory response influence inhibiting innate immune responses innate immune system Innate immunity Interaction interferon interferon regulatory factor involved lung parenchyma manuscript MERS-CoV MHV mice Modification motif NF-κB NF-κB pathway nuclear Pathogenesis pathogenic pathogenicity pathway patients priming proinflammatory Proinflammatory cytokine promote proportion Protein Regulation Replication responses responsible SARS-CoV SARS-CoV E sequence shown Signaling signaling pathway Stress subgenomic mRNA synthesis syndrome TGEV transcription factor transmembrane transmembrane domain triggered vaccine candidates viral infections Viral protein virulence virulence gene virus virus infection [DOI] 10.1016/j.virusres.2014.07.024 PMC 바로가기 [Article Type] Article
Myosins 1 and 6, myosin light chain kinase, actin and microtubules cooperate during antibody-mediated internalisation and trafficking of membrane-expressed viral antigens in feline infectious peritonitis virus infected monocytesResearch Published on 2014-02-122022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] accumulated Actin antibodies Antigen association binding can be used cell lysis complexes coronavirus cortical cytoskeletal experiment Express filaments found Infected infectious inhibiting Intracellular investigated kinase monocyte myosin overcome pathway plasma membranes Protein subsequent Transport transported Treatment Vesicle Viral antigen Viral protein virus [DOI] 10.1186/1297-9716-45-17 PMC 바로가기 [Article Type] Research
Porcine epidemic diarrhea virus (PEDV) co-infection induced chlamydial persistence/stress does not require viral replicationMicrobiology Published on 2014-01-092022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, MERS, [키워드] Chlamydia pecorum absence Alter aminopeptidase N binding CD13 Cell cellular signaling pathway characteristic Chlamydia Chlamydiae chlamydial persistence chlamydial stress response chronic inflammation Co-infection contribute Course Critical Culture cycloheximide de novo demonstrated developmental disease drug epidemic diarrhea experiment Host host cell receptor incubated indicated induce Infected Infection infectious inhibit inhibited non-infectious PEDV performed persistence Porcine epidemic diarrhea virus produced protein synthesis reduced removed Replication replicative required stimulate stressed chlamydiae Vero Cell Viral protein viral replication virus [DOI] 10.3389/fcimb.2014.00020 PMC 바로가기 [Article Type] Microbiology
Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential TherapeuticsResearch Article Published on 2013-08-152022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 5-FU activity antiviral activity antiviral drug Author biochemical Combination compared conserved coronavirus CoV CoV replication CoVs Critical decrease demonstrated determine Epidemic Evidence Exoribonuclease Express Genetic high mutation rate human coronavirus human disease Hypothesis identify increase in inhibitor inhibitory activity lethal MERS-CoV Middle East Mutagenesis Mutation Next-generation sequencing NO nonstructural protein 14 nsp14-ExoN nucleotides Population Potential Prevent Probability Proofreading provide RdRP Replication required respiratory responsible ribavirin RNA RNA synthesis RNA virus SARS-CoV selective sensitivity severe Support susceptible target Therapeutics to define treated Vaccine viral adaptation Viral protein viral RNA synthesis virus virus replication while wild-type zoonotic [DOI] 10.1371/journal.ppat.1003565 PMC 바로가기 [Article Type] Research Article
Inhibitory Effect of Resveratrol against Duck Enteritis Virus In VitroResearch Article Published on 2013-06-112022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] addition age Cell Concentration contagious disease dose-dependent manner duck early stage Effect Enteritis exhibit expression fibroblast found host cells immunofluorescence assay impacted in vitro inactivation Infected Infection inhibit inhibitory activity Mortality nucleus plant Post-infection Protein Replication responsible resveratrol supported suppressed ultrastructure Viral protein virus virus multiplication virus nucleic acid virus replication [DOI] 10.1371/journal.pone.0065213 PMC 바로가기 [Article Type] Research Article
Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA ProductionArticle Published on 2013-01-182022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Affect Altering change changes in coronavirus different Efficiency frameshift Frequency genomic genomic RNA genomic sequence Mutation ORF1a/b Previous studies produced Production protein sequence pseudoknot resulting ribosomal frameshifting RNA RNA sequence SARS Severe acute respiratory syndrome shown synonymous TCID threshold Viral protein viral replication virus virus production [DOI] 10.3390/v5010279 PMC 바로가기 [Article Type] Article
Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivoArticle Published on 2012-07-202022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] accessory protein accessory proteins acute respiratory syndrome Amino acid Analysis analyzed approach cellular conditions coronavirus Coronaviruses cytoplasm described eight ENCODE experiment Factor functions Genome homology immunoprecipitation in vivo infective Interaction involved LC–MS pathogenicity Protein Protein 6 Protein 9b protein–protein interactions Proteins proteomic Replication SARS Coronavirus SARS-CoV SARS-CoV infected cell SARS-CoV infected cells severe shown structural protein Viral protein virus [DOI] 10.1016/j.virusres.2012.07.012 PMC 바로가기 [Article Type] Article