activate – Page 43 – Communicable Diseases Research

Involvement of FOXO Transcription Factors, TRAIL-FasL/Fas, and Sirtuin Proteins Family in Canine Coronavirus Type II-Induced Apoptosis

Research Article

Published on 2011-11-082022-10-28
Journal: PLoS ONE
[Category] Coronavirus, MERS,

Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) Infection

Research Article

Published on 2011-07-072022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus,

[키워드] activate anti-IFN-γ anti-TNF-α Author blockade cascades CD4 CD8 cells characteristic co-expressed Coagulation Combination Control damaged demonstrated described determined exhibited expression Fgl2 FH fibrinogen Fluorescence fulminant viral hepatitis functional hepatocellular IFN-γ immunopathological immunopathological damage Immunotherapy in vivo Infection inhibitory receptor initiate injection investigated led to limit liver Liver damage Lymph node lymph nodes mAb Macrophage maintain mechanism mice Mortality mortality rate mRNA multiple organs murine hepatitis virus Necrosis NK cell occurred organ Pathogenesis peripheral tolerance produced promote Protein Quantitative reduced related RT-PCR sensitive Signaling significantly higher spleen T cells tissue tissue damage tissue lesion tissue lesions TNF-α Transcription was determined wild type wild-type
[DOI] 10.1371/journal.ppat.1001347 PMC 바로가기 [Article Type] Research Article

Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis

인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다

Research Article

Published on 2011-06-232022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type
[DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article

Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice

Research Article

Published on 2009-10-232022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] activate activated Activation Adaptive immune response allergic alveolar macrophage animal model Anti-viral Antigen Author BALB/c mice caused characterized correlated CoV dendritic cell dendritic cells deplete develop DLN draining lymph node Epidemic feature Human human disease human population humans immune response individual inefficient Infected Infection inhibitory inhibitory effect initial Liposome lung lymphopenia MA15 Macrophage mice morbidity and mortality mouse-adapted SARS-CoV Novel coronavirus occurred Patient Poor Prevent prolonged virus persistence PROTECT respiratory Respiratory disease response severe severe disease severe respiratory disease T cell response T cells Therapies TLR3 Toll-like receptor transfer treated virus virus clearance virus excretion virus-specific T cell
[DOI] 10.1371/journal.ppat.1000636 PMC 바로가기 [Article Type] Research Article

Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected Macaques

Research Article

Published on 2007-08-102022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] activate activated acute phase acute respiratory distress acute respiratory syndrome Admission Adult against SARS-CoV analyzed Antiviral antiviral signaling Atypical Author cause Cell cells characterized chemokine genes chemokines circumvent Complication coronavirus Critical cynomolgus macaque cytokine demonstrated early IFN signaling Effect event examined functional gene expression profile gene signature Genomics highlight Host host response IFNs IL-8 immune response immunohistochemistry in vitro experiments individuals induction Infection innate immune response Innate immunity intensive care involved IP-10 lung Lung pathology macaque macaques nuclear translocation Pathogenesis pathogenic pathway phosphorylated Pneumonia protective immune response regulated required SARS patient SARS-CoV SARS-CoV infection SARS-CoV–infected cells severe shown Stat1 subset syndrome Transcription transcription factor type I interferon viral infection virus virus replication
[DOI] 10.1371/journal.ppat.0030112 PMC 바로가기 [Article Type] Research Article

Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus

Research

Published on 2006-03-292022-10-28
Journal: Virology Journal
[Category] Coronavirus,