High dose subcutaneous Anakinra to treat acute respiratory distress syndrome secondary to cytokine storm syndrome among severely ill COVID-19 patients중증 코로나19 환자에서 사이토카인 폭풍 증후군에 이차적으로 발생하는 급성 호흡곤란 증후군 치료를 위한 고용량 피하 아나킨라Article Published on 2020-12-012022-09-12 Journal: Journal of autoimmunity [Category] SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome adverse effect age Aminotransferase Anakinra ARDS Cohort cohort of patient cohort study cohorts Combination COVID-19 COVID-19 patient CRP CSS Cytokine storm syndrome D-dimer develop distress dose elevated exhibited exhibiting ferritin group hyperinflammation hyperinflammatory state IL-1 IL-6 IL-6 inhibitor in both group Infection Inflammatory inhibition initial intravenous males median multi-organ failure non-responder outcome paO2/fiO2 PaO2/FiO2 ratio Patient patients patients treated produced propensity score matching reduction Resolution Respiratory function respond SARS-CoV2 severe COVID-19 significantly increased single dose Subcutaneous syndrome TCZ therapy Tocilizumab treat treated Treatment Two patient was selected was used [DOI] 10.1016/j.jaut.2020.102537 PMC 바로가기 [Article Type] Article
Dietary Habits and Psychological States during COVID-19 Home Isolation in Italian College Students: The Role of Physical ExerciseObservational Study Published on 2020-11-282022-10-04 Journal: Nutrients [Category] 임상, [키워드] adverse effect Analysis collected college COVID-19 diet dietary habit Effect exercise Factor home investigated Isolation Italian lifestyle Linear model lockdown males mediation model mental health mood physical Quality of life quarantine reduce role state total variance variable was used young adults [DOI] 10.3390/nu12123660 PMC 바로가기 [Article Type] Observational Study
Adverse reactions of drugs specifically used for treatment of SARS-CoV-2 infectionSARS-CoV-2 감염 치료에 특별히 사용되는 약물의 부작용Review Published on 2020-11-272022-09-11 Journal: Medicina clínica [Category] 치료제, [키워드] Adverse Adverse drug reaction Adverse drug reactions adverse effect Adverse reaction Adverse reactions Alergia a medicamento allergy approved COVID-19 COVID-19 treatment described disease drug Drug allergy drug reaction Efficacy and safety healthcare worker Healthcare workers hospital immunological Infection Inflammatory response initial Numerous pandemic pharmacovigilance Program Reacción adversa a medicamento Registered SARS-CoV-2 SARS-COV-2 infection the SARS-CoV-2 thought Tratamiento COVID-19. Treatment Viral viral infection [DOI] 10.1016/j.medcli.2020.06.019 PMC 바로가기 [Article Type] Review
Mental health of Urban Mothers (MUM) study: a multicentre randomised controlled trial, study protocolMUM(도시 어머니의 정신 건강) 연구: 다기관 무작위 대조 시험, 연구 프로토콜Global Health Published on 2020-11-272022-09-10 Journal: BMJ Open [Category] 임상, [키워드] addressed adverse effect analysed analyses Analysis Anxiety Anxiety Disorder anxiety disorders approved center children Chinese clinical conducted consequence COVID-19 COVID-19 pandemic Declaration of Helsinki Depression depression & mood disorders disease disorder dissemination during pregnancy Edinburgh Effect effective Effectiveness ethical review board Ethics expected family friends Generalised anxiety disorder Good Good Clinical Practice Health health problems healthcare Helsinki Hong Kong identify Impact Impact Event in some increased risk Infectious diseases International Internet Intervention IRB Karolinska Institute lead less media mental health Mental health disorder mental health disorders mental health problem mental health problems multicentre National outcome outcomes pandemic peer peer-reviewed perinatology physical Post-traumatic stress disorder Practice Pregnancy pregnant women prenatal randomised randomised controlled trial receive recruited reducing registration number reported reproductive medicine risk score severity Shanghai social distancing social media Sponsor spread to Stress Study protocol Subgroup analyses Support Trial Trial Registration Number university urban usual care women [DOI] 10.1136/bmjopen-2020-041133 PMC 바로가기 [Article Type] Global Health
Evaluating the efficacy and safety of the myrtle ( Myrtus communis ) in treatment and prognosis of patients suspected to novel coronavirus disease (COVID-19): study protocol for a randomized controlled trialRandomized Controlled Trial Published on 2020-11-262022-10-04 Journal: Trials [Category] SARS, 임상, [키워드] M. communis addition adverse effect age China clinical clinical status clinically suspected Coronavirus pneumonia COVID-19 COVID-19 disease disease distress Efficacy Efficacy and safety evaluated Evaluating Evidence Herb identify in both group manuscript Mild moderate mortality rate Myrtle Myrtus communis novel coronavirus disease Open-label outbreak Outpatient Persian medicine prognosis of patient protocol Randomized controlled trial receive Registered registry study outcome Study protocol Symptom therapeutic therapy Treatment Trial website [DOI] 10.1186/s13063-020-04915-w PMC 바로가기 [Article Type] Randomized Controlled Trial
Pregnancy and Breastfeeding During COVID-19 Pandemic: A Systematic Review of Published Pregnancy CasesCOVID-19 팬데믹 기간 동안의 임신과 모유 수유: 출판된 임신 사례에 대한 체계적인 검토Public Health Published on 2020-11-232022-09-12 Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, [키워드] Admission adverse effect age amniotic analyzed assumption Blood breast milk Breastfeeding conducted counseling COVID-19 COVID-19 pandemic deaths diagnosed diagnosed with COVID-19 died discharged Evidence identify intensive care knowledge Neonatal Newborn occurred outcome perinatal outcomes Placenta positive Pregnancy pregnant pregnant women Prevent reported required review SARS-CoV-2 SARS-COV-2 infection the SARS-CoV-2 virus Transmission vertical transmission Web with COVID-19 [DOI] 10.3389/fpubh.2020.558144 PMC 바로가기 [Article Type] Public Health
Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19Article Published on 2020-11-182022-10-04 Journal: Scientific Reports [Category] 변종, 치료기술, [키워드] addition Administered adverse effect aluminum applied candidate vaccine Combination COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 vaccine CpG cross-neutralize cytokine D614G variant development dominant elicited ENhance health emergency hydroxide immunized immunized mice immunology immunopathology lentivirus MERS-CoV mice Microbiology mitigate neutralizing antibody prefusion Prevent pseudotyped pseudovirus reporter S-2P SARS-CoV-2 spike antigen SARS-CoV-2 spike protein secreted sera splenocyte subunit Support Th1 the antibody the spike protein TLR9 Toll-like receptor Treatment two-dose regimen Vaccine was selected wild-type SARS-CoV-2 [DOI] 10.1038/s41598-020-77077-z PMC 바로가기 [Article Type] Article
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential201 Published on 2020-11-182022-10-29 Journal: Open Biology [Category] COVID-19, [키워드] (ADP-ribosyl)hydrolase ADP-ribosylation adverse effect alphavirus Analysis Antiviral antiviral poly(ADP-ribosyl)polymerases binding cellular conserved Coronaviral coronavirus COVID-19 cross-reactivity disease drug design evaluate Features homology Host human macrodomain hydrolysis immune response implicated infections kidney Ligand macrodomain Necrosis non-structural protein 3 PARP14 pharmacological post-translational modification raised Regulation SARS-CoV-2 spleen the Coronaviridae therapeutic targets Togaviridae Viral macrodomain Virus Disease were used X domain [DOI] 10.1098/rsob.200237 PMC 바로가기 [Article Type] 201
Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort studyCOVID-19 대유행이 암 서비스 및 암 및 복합상병 환자의 1년 초과 사망률에 미치는 영향 추정: 암 치료, 암 사망 및 인구 기반 코호트 연구에 대한 거의 실시간 데이터Multicenter Study Published on 2020-11-172022-09-10 Journal: BMJ Open [Category] Fulltext, SARS, 치료기술, [키워드] adverse effect affected best Cancer cancer patient Cancer patients cancers Care Chemotherapy clinical Cohort Comorbidity contribute COVID-19 COVID-19 pandemic death deaths Decline determine England Estimated excess excess mortality general practitioner health informatics hospital lockdown lowest mitigate Mortality mortality risk mortality risks Multimorbidity National objective oncology pandemic Patient population-based cohort Practice primary care reduction Relative risk Result risk supply These data [DOI] 10.1136/bmjopen-2020-043828 PMC 바로가기 [Article Type] Multicenter Study
Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid DevelopmentArticle Published on 2020-11-132022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] accompanied Activation acute respiratory syndrome adverse effect AEC Affect alveolar alveolar organoid angiotensin-converting enzyme 2 Cell childhood clade cofactor coronavirus demonstrated development developmental dPM2.5 EMT epithelial Evidence explain exposure to expression Extracellular fibrosis had no Human human pluripotent stem cells in vitro incidence infancy Inflammation investigated lack lung Lung function matter mechanism multicellular nicotinamide adenine dinucleotide Organoid Particulate phosphate platform pluripotent stem cell prenatal promoted protease Protein provided pulmonary disease receptor reduced Research SARS-CoV-2 serine 2 Signaling significantly STEM susceptibility target cells Toxicity toxin transition transmembrane treated Treatment unique upregulated upregulation virus [DOI] 10.3390/ijerph17228410 PMC 바로가기 [Article Type] Article