A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to NeuroinflammationT 세포 수용체 신호 분자 Vav1의 천연 변이체는 이펙터 T 세포 기능과 신경 염증에 대한 감수성을 모두 감소시킵니다Research Article Published on 2016-07-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation Affect alteration Antigen antigen receptor Autoimmune candidate gene CD4 T cell CD4 T cells changes in chromosome 9 Control cytokine cytokine production Cytokines Diseases effector effector T cell effector T cells FOXP3 function functions Genetic genetic study GM-CSF guanine highlight IFN-γ IL-17 immune system immunization Inflammatory cytokine Inflammatory cytokines intrinsic leads locus mechanism mice MOG molecule natural Neuroinflammation Non-synonymous normal enzymatic activity nucleotide peptide phenotype physiological polymorphism Polymorphisms proportion Quantitative receptor reduce reduced Regulatory T cell regulatory T cells Signaling susceptibility T cell T cell receptor T cells Th1/Th17 These data transducing Treg variant Vav1 [DOI] 10.1371/journal.pgen.1006185 PMC 바로가기 [Article Type] Research Article
SARS Coronavirus Fusion Peptide-Derived Sequence Suppresses Collagen-Induced Arthritis in DBA/1J MiceArticle Published on 2016-06-282022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] acute respiratory syndrome antiviral immune response approach Arthritis Autoimmune cartilage chain coronavirus disease dosage Efficacy evade Evidence fusion fusion peptide Host Host immune response hosts Hypothesis immune immunomodulatory in vivo include incorporation increase Infection involved lipoprotein mice modulate molecular mechanism multichain peptide PROTECT receptor replicate SARS-CoV sequence Signaling significantly suggested Support T cell receptor target TCR therapeutic strategy transferred Viral immune evasion virus [DOI] 10.1038/srep28672 PMC 바로가기 [Article Type] Article
Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease건강 및 면역 매개 질환의 여러 세포 유형에서 eQTL 매핑을 통한 유전자형-표현형 연관성에 대한 통찰력Research Article Published on 2016-03-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Active disease Affect Analysis anti-neutrophil cytoplasmic antibody association Autoimmune Autoimmune diseases blood cell blood vessel blood vessels bowel Cancer cell types cellular cellular activation clinical disease complex complex system contribute cytoplasmic damage database dependent on disease risk disease-associated loci DNA Effect eQTL eQTL analysis eQTL mapping eQTLs estimate examined Examining expression expression data expression quantitative trait loci FIVE Gene Expression Genetic genetic control Genetic studies Genetic variant genetic variants genetics Genome-wide association studies Gut GWAS healthy healthy control healthy controls help Human immune system human inflammatory diseases identifying immune Immune cell immune cell type immune cells immune-mediated diseases in vitro include Infection Inflammation Inflammatory Inflammatory bowel disease inflammatory disease Inflammatory diseases insight investigated joint knowledge leucocyte loci majority mapping Multiple observation Pathogenesis Patient performed proportion PROTECT provide Quantitative regions resulting risk specificity subset subtype tissue tissues Treatment Type variant Vasculitis White blood cell [DOI] 10.1371/journal.pgen.1005908 PMC 바로가기 [Article Type] Research Article
Immunohistochemical screening for antibodies in recent onset type 1 narcolepsy and after H1N1 vaccinationComparative Study Published on 2015-06-152023-06-25 Journal: Journal of neuroimmunology [Category] 신종인플루엔자, [키워드] Autoimmune Cataplexy hypothalamus immunohistochemistry Narcolepsy type 1. [DOI] 10.1016/j.jneuroim.2015.04.008 [Article Type] Comparative Study
How apoptotic β-cells direct immune response to tolerance or to autoimmune diabetes: a review세포 사멸 β 세포가 내성 또는 자가 면역 당뇨병에 대한 면역 반응을 지시하는 방법: 리뷰Original Paper Published on 2015-01-222022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] β-Cells Activation antigen presenting cell antigen presenting cells APCS Apoptosis apoptotic cell clearance apoptotic cells apoptotic β-cell autoantigen Autoantigens Autoimmune autoimmune attack autoimmune diabetes Autoimmune disease Autoimmune diseases Autoimmunity Cell contribute contributing to dendritic cells diabetes Effect Efferocytosis endogenous insulin secretion immune response immune tolerance immunological tolerance immunotherapies Immunotherapy increase in induce Inflammation insulin insulin-producing β-cell insulin-producing β-cells long-term tolerance maintenance maturation mechanism medical health challenge metabolic disease pancreatic islet pancreatic islets pancreatic islets of Langerhans Patient physiological mechanism Research self T1D target cell target cells therapy Tolerance tolerance to self translational Treatment Type 1 diabete Type 1 diabetes β-cell β-cells [DOI] 10.1007/s10495-015-1090-8 PMC 바로가기 [Article Type] Original Paper
The effect of rituximab therapy on immunoglobulin levels in patients with multisystem autoimmune diseaseResearch Article Published on 2014-05-252024-09-02 Journal: BMC Musculoskeletal Disorders [Category] 대상포진, [키워드] Autoimmune B cell hypogammaglobulinaemia IgG Infection rituximab systemic lupus erythematosus (SLE) Vasculitis [DOI] 10.1186/1471-2474-15-178 PMC 바로가기 [Article Type] Research Article
Case Definitions, Diagnostic Algorithms, and Priorities in Encephalitis: Consensus Statement of the International Encephalitis Consortiumarticle Published on 2013-10-152024-09-02 Journal: Clinical infectious diseases : an official publication of the Infectious [Category] 대상포진, [키워드] Autoimmune Encephalitis guidelines host genetics Viral [DOI] 10.1093/cid/cit458 PMC 바로가기 [Article Type] article
Different Mechanisms of Inflammation Induced in Virus and Autoimmune-Mediated Models of Multiple Sclerosis in C57BL6 MiceResearch Article Published on 2013-08-282022-10-27 Journal: BioMed Research International [Category] Coronavirus, [키워드] accumulated Acute inflammation Autoimmune CD4 CD8 Central nervous system chronic disease CNS Course demonstrated Demyelination disease distribution glycoprotein Immunosuppression induce induced Inflammation Inflammatory Injury involved mechanism MHV MHV-A59 mice microglia Model MOG Multiple pathology patients promote responsible sclerosis significant difference T cell T cells the disease viral toxicity viral-induced [DOI] 10.1155/2013/589048 PMC 바로가기 [Article Type] Research Article
Two rare cases of retinal vasculitis following vaccination접종 후 망막 혈관염의 드문 증례 두 가지journal-article Published on 2013-05-012024-07-30 Journal: Scottish Medical Journal [Category] 파상풍, [키워드] Autoimmune immunisation Retinitis vaccination Vasculitis [DOI] 10.1177/0036933013482660 [Article Type] journal-article
MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus ErythematosusMicroRNA-3148은 전신성 홍반성 루푸스와 관련된 톨 유사 수용체 7 변이체의 대립형질 발현을 조절합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3′ UTR 3′UTR activate affecting African Americans allelic Americans Antigen Asian Asians association Author Autoimmune Autoimmune disease binding binding site C allele C-allele carriers conducted contributed Control copy number correlated debilitating autoimmune disease decrease Degradation dose-dependent downregulated driven by duplication elevated Epigenetic European Evidence exhibited exhibiting expression functional G allele G-allele genomic greater HEK-293 HEK-293 cell HEK-293 cells Human identify IFN IFN-α pathway increased risk independent individual innate immune activation lack led to luciferase luciferase activity Lupus lupus erythematosus lupus-like disease mechanism microRNA microRNA-3148 microRNA–gene miR-3148 modulation mononuclear cell mononuclear cells mRNA murine model non-risk allele non-risk C allele nuclear nucleotide Odds ratio overexpression Pathways PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells polymorphism predicted promote Protein protein level provide R 2 reduction regulate Regulatory reported reporter reporter gene respond resulting risk sequence signaling pathways significantly increased single nucleotide Single nucleotide polymorphism SLE SLE patient SLE patients SNP subject susceptibility systemic systemic lupus erythematosus the strongest These data TLR7 TLR7 gene TLR7 mRNA TLR7-TLR8 region TLR7/8/9 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors transcript transcript level transcripts transfected cells type I interferon UTR variant Variation while [DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article